Q9ZLE0 (KDGL_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diacylglycerol kinase
Short name=DAGK
EC=2.7.1.107

Alternative name(s):
Diglyceride kinase
Short name=DGK

Gene names

Name:	dgkA
Ordered Locus Names:	jhp_0640

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Recycling of diacylglycerol produced during the turnover of membrane phospholipid By similarity.
Catalytic activity	ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the bacterial diacylglycerol kinase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Diacylglycerol kinase		PRO_0000195265
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Topological domain	56 – 57	2	Periplasmic Potential
	Transmembrane	58 – 78	21	Helical; Potential
	Topological domain	79 – 106	28	Cytoplasmic Potential
	Transmembrane	107 – 127	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZLE0 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: AC96B8630A8B1B7D	FASTA	128	14,598
	10 20 30 40 50 60 MSDFKVPPKA KGFKRLFKAL FYSKDGLKCA WAEESAFRQI VILALFCIVL ASYLTKDFLE 70 80 90 100 110 120 WGLLILPCFL SVVIELINSS IEKAVDFTGT EFHPLAKKAK DMASSAQLIG LIFWAFIWGR YLLTLYFN

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06218.1.
PIR	D71906.
RefSeq	NP_223358.1. NC_000921.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZLE0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	890264.
GenomeReviews	Gene locus jhp_0640 in contig AE001439_GR.
KEGG	hpj:jhp0640.
NMPDR	fig|85963.1.peg.636.
PATRIC	20605991. VBIHelPyl98156_0701.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0818.
HOGENOM	HBG729542.
OMA	KALFYSK.
ProtClustDB	CLSK496163.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0640-MONOMER.
Family and domain databases
InterPro	IPR000829. Diacylglycerol_kinase_prok. [Graphical view]
KO	K00901.
Pfam	PF01219. DAGK_prokar. 1 hit. [Graphical view]
PROSITE	PS01069. DAGK_PROKAR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KDGL_HELPJ

Accession

Primary (citable) accession number: Q9ZLE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program