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Q9ZL96

- TRMB_HELPJ

UniProt

Q9ZL96 - TRMB_HELPJ

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
Binding sitei232 – 2321SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-696-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:jhp_0684
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400tRNA (guanine-N(7)-)-methyltransferasePRO_0000171336Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0684.

Structurei

3D structure databases

ProteinModelPortaliQ9ZL96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZL96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHFLAKLDS KPLEYPLIRG DFCFHREFLS LKHPTKSCVH ASFKNDVFLL
60 70 80 90 100
QKIRRAGDFL IKSEKATPLK REILKQALRI YSQSFEVISH NLQENSKHAS
110 120 130 140 150
QKKALDLETF EDFIQKNQAP ILIEIGFGSG RHLIELAKNN PTTTCLGIEI
160 170 180 190 200
HTPSIAQALK QIELLDLKNL HILQGDGRLV LESMPNHRCE KIFVHFPVPW
210 220 230 240 250
NEKKHRRVLS EKFLNEALRV LKPRGFLELR TDDSLCFEDS LKLALKNFQC
260 270 280 290 300
EIEIKKNAQI PVVSKYEARW NKLKKDIYDL KIYSLGLDEN PTQNHALDFS
310 320 330 340 350
FDTITIDKES VGAILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW
360 370 380 390 400
PVRLFVLLAE NQVFYLNKSP LKTLNNHKAH LLLQNILSQK ELDERDHRSE
Length:400
Mass (Da):46,403
Last modified:May 1, 1999 - v1
Checksum:i8B92B929183D3573
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06272.1.
PIRiD71900.
RefSeqiNP_223402.1. NC_000921.1.
WP_001119966.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06272; AAD06272; jhp_0684.
GeneIDi890215.
KEGGihpj:jhp0684.
PATRICi20606087. VBIHelPyl98156_0749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06272.1 .
PIRi D71900.
RefSeqi NP_223402.1. NC_000921.1.
WP_001119966.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZL96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06272 ; AAD06272 ; jhp_0684 .
GeneIDi 890215.
KEGGi hpj:jhp0684.
PATRICi 20606087. VBIHelPyl98156_0749.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HPYL85963:GJB9-696-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiTRMB_HELPJ
AccessioniPrimary (citable) accession number: Q9ZL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3