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Q9ZL96

- TRMB_HELPJ

UniProt

Q9ZL96 - TRMB_HELPJ

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
    Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
    Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-696-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:jhp_0684
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400tRNA (guanine-N(7)-)-methyltransferasePRO_0000171336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp0684.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZL96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiSKYEARW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZL96-1 [UniParc]FASTAAdd to Basket

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    MPHFLAKLDS KPLEYPLIRG DFCFHREFLS LKHPTKSCVH ASFKNDVFLL    50
    QKIRRAGDFL IKSEKATPLK REILKQALRI YSQSFEVISH NLQENSKHAS 100
    QKKALDLETF EDFIQKNQAP ILIEIGFGSG RHLIELAKNN PTTTCLGIEI 150
    HTPSIAQALK QIELLDLKNL HILQGDGRLV LESMPNHRCE KIFVHFPVPW 200
    NEKKHRRVLS EKFLNEALRV LKPRGFLELR TDDSLCFEDS LKLALKNFQC 250
    EIEIKKNAQI PVVSKYEARW NKLKKDIYDL KIYSLGLDEN PTQNHALDFS 300
    FDTITIDKES VGAILKTPKI IKEGYFVHVC NIYENKGDFL VELSMGDFDW 350
    PVRLFVLLAE NQVFYLNKSP LKTLNNHKAH LLLQNILSQK ELDERDHRSE 400
    Length:400
    Mass (Da):46,403
    Last modified:May 1, 1999 - v1
    Checksum:i8B92B929183D3573
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06272.1.
    PIRiD71900.
    RefSeqiNP_223402.1. NC_000921.1.
    WP_001119966.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06272; AAD06272; jhp_0684.
    GeneIDi890215.
    KEGGihpj:jhp0684.
    PATRICi20606087. VBIHelPyl98156_0749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06272.1 .
    PIRi D71900.
    RefSeqi NP_223402.1. NC_000921.1.
    WP_001119966.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZL96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0684.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06272 ; AAD06272 ; jhp_0684 .
    GeneIDi 890215.
    KEGGi hpj:jhp0684.
    PATRICi 20606087. VBIHelPyl98156_0749.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi SKYEARW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci HPYL85963:GJB9-696-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiTRMB_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZL96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3