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Q9ZL75

- MOAA_HELPJ

UniProt

Q9ZL75 - MOAA_HELPJ

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Protein
Cyclic pyranopterin monophosphate synthase
Gene
moaA, jhp_0705
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity.UniRule annotation

Catalytic activityi

GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.
Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141GTP By similarity
Metal bindingi21 – 211Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi25 – 251Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei27 – 271S-adenosyl-L-methionine By similarity
Metal bindingi28 – 281Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei64 – 641GTP By similarity
Binding sitei68 – 681S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei95 – 951GTP By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei155 – 1551GTP By similarity
Binding sitei189 – 1891S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi249 – 2491Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi266 – 2661Iron-sulfur 2 (4Fe-4S-substrate) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-717-MONOMER.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene namesi
Name:moaA
Ordered Locus Names:jhp_0705
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. molybdopterin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Cyclic pyranopterin monophosphate synthaseUniRule annotation
PRO_0000152968Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85963.jhp0705.

Structurei

3D structure databases

ProteinModelPortaliQ9ZL75.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 2563GTP binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2896.
KOiK03639.
OMAiREYPGDI.
OrthoDBiEOG64XXNN.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01225_B. MoaA_B.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamiPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02666. moaA. 1 hit.
PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZL75-1 [UniParc]FASTAAdd to Basket

« Hide

MLVDSFNRVI DYIRVSVTKQ CNFRCQYCMP TTPLDFFDDE ELLPLDNVLE    50
FLKIAIDEGV KKIRITGGEP LLRKGLDEFI AKLHAYNKEV ALVLSTNGFS 100
LKKMAKGLKD AGLSRVNVSL DSLKSDRVLK ISQKDALKNT LEGIEESLKV 150
GLKLKLNTVV MKGVNDDEIL ELLEYAKNRS IQIRYIEFME NTHAKSLVKG 200
LKEKEILDLI AQKYKIMGME KPKQGSSKIY TLENGYQFGI IAPHSDDFCQ 250
SCNRIRLASD GKICPCLYYQ DAIDAKEAII NKDTKMMKRL LKQSIINKPE 300
KNMWNDKNGG TPTRAFYYTG G 321
Length:321
Mass (Da):36,455
Last modified:May 1, 1999 - v1
Checksum:iB7802F6FCC6D2197
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06280.1.
PIRiA71900.
RefSeqiNP_223423.1. NC_000921.1.
WP_010882557.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06280; AAD06280; jhp_0705.
GeneIDi890191.
KEGGihpj:jhp0705.
PATRICi20606133. VBIHelPyl98156_0772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06280.1 .
PIRi A71900.
RefSeqi NP_223423.1. NC_000921.1.
WP_010882557.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZL75.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85963.jhp0705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06280 ; AAD06280 ; jhp_0705 .
GeneIDi 890191.
KEGGi hpj:jhp0705.
PATRICi 20606133. VBIHelPyl98156_0772.

Phylogenomic databases

eggNOGi COG2896.
KOi K03639.
OMAi REYPGDI.
OrthoDBi EOG64XXNN.

Enzyme and pathway databases

UniPathwayi UPA00344 .
BioCyci HPYL85963:GJB9-717-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01225_B. MoaA_B.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view ]
Pfami PF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02666. moaA. 1 hit.
PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiMOAA_HELPJ
AccessioniPrimary (citable) accession number: Q9ZL75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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