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Q9ZL75

- MOAA_HELPJ

UniProt

Q9ZL75 - MOAA_HELPJ

Protein

Cyclic pyranopterin monophosphate synthase

Gene

moaA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).UniRule annotation

    Catalytic activityi

    GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate.UniRule annotation
    Binds 1 S-adenosyl-L-methionine per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141GTPUniRule annotation
    Metal bindingi21 – 211Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi25 – 251Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei27 – 271S-adenosyl-L-methionineUniRule annotation
    Metal bindingi28 – 281Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei64 – 641GTPUniRule annotation
    Binding sitei68 – 681S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei95 – 951GTPUniRule annotation
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Binding sitei155 – 1551GTPUniRule annotation
    Binding sitei189 – 1891S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenUniRule annotation
    Metal bindingi249 – 2491Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi266 – 2661Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Molybdenum cofactor biosynthesis

    Keywords - Ligandi

    4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-717-MONOMER.
    UniPathwayiUPA00344.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic pyranopterin monophosphate synthaseUniRule annotation (EC:4.1.99.18UniRule annotation)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein AUniRule annotation
    Gene namesi
    Name:moaAUniRule annotation
    Ordered Locus Names:jhp_0705
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. molybdopterin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Cyclic pyranopterin monophosphate synthasePRO_0000152968Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi85963.jhp0705.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZL75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 2563GTP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. MoaA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2896.
    KOiK03639.
    OMAiREYPGDI.
    OrthoDBiEOG64XXNN.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01225_B. MoaA_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view]
    PfamiPF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02666. moaA. 1 hit.
    PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZL75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVDSFNRVI DYIRVSVTKQ CNFRCQYCMP TTPLDFFDDE ELLPLDNVLE    50
    FLKIAIDEGV KKIRITGGEP LLRKGLDEFI AKLHAYNKEV ALVLSTNGFS 100
    LKKMAKGLKD AGLSRVNVSL DSLKSDRVLK ISQKDALKNT LEGIEESLKV 150
    GLKLKLNTVV MKGVNDDEIL ELLEYAKNRS IQIRYIEFME NTHAKSLVKG 200
    LKEKEILDLI AQKYKIMGME KPKQGSSKIY TLENGYQFGI IAPHSDDFCQ 250
    SCNRIRLASD GKICPCLYYQ DAIDAKEAII NKDTKMMKRL LKQSIINKPE 300
    KNMWNDKNGG TPTRAFYYTG G 321
    Length:321
    Mass (Da):36,455
    Last modified:May 1, 1999 - v1
    Checksum:iB7802F6FCC6D2197
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06280.1.
    PIRiA71900.
    RefSeqiNP_223423.1. NC_000921.1.
    WP_010882557.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06280; AAD06280; jhp_0705.
    GeneIDi890191.
    KEGGihpj:jhp0705.
    PATRICi20606133. VBIHelPyl98156_0772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06280.1 .
    PIRi A71900.
    RefSeqi NP_223423.1. NC_000921.1.
    WP_010882557.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZL75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06280 ; AAD06280 ; jhp_0705 .
    GeneIDi 890191.
    KEGGi hpj:jhp0705.
    PATRICi 20606133. VBIHelPyl98156_0772.

    Phylogenomic databases

    eggNOGi COG2896.
    KOi K03639.
    OMAi REYPGDI.
    OrthoDBi EOG64XXNN.

    Enzyme and pathway databases

    UniPathwayi UPA00344 .
    BioCyci HPYL85963:GJB9-717-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01225_B. MoaA_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view ]
    Pfami PF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02666. moaA. 1 hit.
    PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiMOAA_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZL75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3