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Protein

Cadmium, zinc and cobalt-transporting ATPase

Gene

cadA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell.

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).
ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Cadmium or zinc or cobaltPROSITE-ProRule annotation1
Metal bindingi14Cadmium or zinc or cobaltPROSITE-ProRule annotation1
Active sitei3884-aspartylphosphate intermediateBy similarity1
Metal bindingi583MagnesiumPROSITE-ProRule annotation1
Metal bindingi587MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Cadmium, Cobalt, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium, zinc and cobalt-transporting ATPase (EC:3.6.3.3, EC:3.6.3.5)
Gene namesi
Name:cadA
Ordered Locus Names:jhp_0727
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicBy similarityAdd BLAST72
Transmembranei73 – 92Helical; Name=1By similarityAdd BLAST20
Topological domaini93 – 102ExtracellularBy similarity10
Transmembranei103 – 124Helical; Name=2By similarityAdd BLAST22
Topological domaini125 – 131CytoplasmicBy similarity7
Transmembranei132 – 151Helical; Name=3By similarityAdd BLAST20
Topological domaini152 – 154ExtracellularBy similarity3
Transmembranei155 – 174Helical; Name=4By similarityAdd BLAST20
Topological domaini175 – 308CytoplasmicBy similarityAdd BLAST134
Transmembranei309 – 327Helical; Name=5By similarityAdd BLAST19
Topological domaini328 – 332ExtracellularBy similarity5
Transmembranei333 – 350Helical; Name=6By similarityAdd BLAST18
Topological domaini351 – 635CytoplasmicBy similarityAdd BLAST285
Transmembranei636 – 657Helical; Name=7By similarityAdd BLAST22
Topological domaini658 – 665ExtracellularBy similarity8
Transmembranei666 – 681Helical; Name=8By similarityAdd BLAST16
Topological domaini682 – 686CytoplasmicBy similarity5

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461771 – 686Cadmium, zinc and cobalt-transporting ATPaseAdd BLAST686

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0727.

Structurei

3D structure databases

ProteinModelPortaliQ9ZL53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63HMAPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK01534.
OMAiAQVVIMN.
OrthoDBiPOG091H00YH.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 1 hit.
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZL53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEYHIHNLD CPDCAAKLER DLNKLDYVKK AQINFSTSKL FLDTSDFEKV
60 70 80 90 100
KAFIKQNEPH LSLSFKEAAE KPLSFTPLIA TIAVFLGAIL ILHLEPSPFI
110 120 130 140 150
EKAVFVVLAL VYLISGKDVI LGAFRGLRKG QFFDENALML IATIAAFCVG
160 170 180 190 200
AYEESVSIMV FYSAGEFLQI LAIARSKKSL KALVDVAPNL AYLKKGDTLV
210 220 230 240 250
SVAPEDLRIN DIVVVKVGEK VPVDGVVIKG ESLLDERALS GESMPVNVSE
260 270 280 290 300
RSKVLGGSLN LKAVLEIQVE KLYKDSSIAK VVDLVQQATN EKSETEKFIT
310 320 330 340 350
KFSRYYTPSV LFIALMIAVL PPLFSMGSFD EWIYRGLVAL MVSCPCALVI
360 370 380 390 400
SVPLGYFGGV GAASRKGILM KGVHVLEVLT QTKSIAFDKT GTLTKGVFKV
410 420 430 440 450
VDIVPQNGHS KEEVLHYASC SQLLSTHPIA LSIQKACEEM LKDDKHQHDI
460 470 480 490 500
KNYEELSGMG VKAQCHTDLI IAGNEKMLDQ FHIAHSPSPE NGTIVHVAFN
510 520 530 540 550
QTYIGYIVIS DEIKDDAIEC LRDLKAQGIE NFCILSGDRK SATESIARTL
560 570 580 590 600
GCEYHASLLP EEKTSVFKTF KERYKAPAIF VGDGINDAPT LASADVGIGM
610 620 630 640 650
GKGSELSKQS ADIVITNDSL SSLVKVLAIA KKTKSIIWQN ILFALGIKAV
660 670 680
FIVLGLMGVA SLWEAVFGDV GVTLLALANS MRTMRA
Length:686
Mass (Da):74,837
Last modified:May 1, 1999 - v1
Checksum:i01E39A3B057476E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06308.1.
PIRiE71895.
RefSeqiWP_001158764.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06308; AAD06308; jhp_0727.
KEGGihpj:jhp_0727.

Similar proteinsi

Entry informationi

Entry nameiHMCT_HELPJ
AccessioniPrimary (citable) accession number: Q9ZL53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families