Reviewed, UniProtKB/Swiss-Prot Q9ZL20 (DHOM_HELPJ)

Names and origin

Protein names

Recommended name:
    Homoserine dehydrogenase
      Short name=HDH
    EC=1.1.1.3

Gene names

Name:	hom
Ordered Locus Names:	jhp_0761

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Sequence similarities	Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Homoserine dehydrogenase		PRO_0000066695
Regions
	Domain	342 – 419	78	ACT
	Nucleotide binding	10 – 17	8	NADP By similarity
Sites
	Active site	201	1	Proton donor Potential
	Binding site	103	1	NADP By similarity
	Binding site	186	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZL20-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 4DC5921EB61D4A78	FASTA	421	46,247
	10 20 30 40 50 60 MKKRLNIGLV GLGCVGSTVA KILQENQEII KDRAGVEIKI KKAVVRDVKK HKGYAFEISD 70 80 90 100 110 120 DLESVIEDKG IDIVVELMGG VEAPYLLAKK TLAKQKAFVT ANKAMLAYHR YELEQIAKNT 130 140 150 160 170 180 PIGFEASVCG GIPIIKALKD GLSANHILSF KGILNGTSNY ILSQMFKNQA SFKDALKDAQ 190 200 210 220 230 240 HLGYAELNPE FDIKGIDAAH KLLILASLAY GIDAKLEEIL IEGIEKIEPD DMEFAKEFGY 250 260 270 280 290 300 SIKLLGIAKK HQDCIELRVH PSMIKNECML SKVDGVMNAI SVIGDKVGET LYYGAGAGGE 310 320 330 340 350 360 PTASAVISDI IEIARKKSSL MLGFETPQKL PLKPKEEIQC AYYARLLVSD EKGVFSQISA 370 380 390 400 410 420 ILAQNDISLN NVLQKEIPQS NKAKILFSTH TTNEKSMLNA LKELENLQSV LDTPKMIRLE N

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD06338.1.
PIR	C71893.
RefSeq	NP_223479.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZL20.
Genome annotation databases
GeneID	890134.
GenomeReviews	Gene locus jhp_0761 in contig AE001439_GR.
KEGG	hpj:jhp0761.
NMPDR	fig|85963.1.peg.757.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZL20.
OMA	LGIVNGT.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0761-MON.
BRENDA	1.1.1.3. 295085.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. Homoserine_dehydrogenase. IPR001342. Homoserine_dehydrogenase_cat. IPR019811. Homoserine_dehydrogenase_CS. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHOM_HELPJ

Accession

Primary (citable) accession number: Q9ZL20

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)