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Q9ZL00

- THID_HELPJ

UniProt

Q9ZL00 - THID_HELPJ

Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-795-MONOMER.
    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase
    Short name:
    HMP kinase
    Hydroxymethylpyrimidine phosphate kinase
    Short name:
    HMP-P kinase
    Short name:
    HMP-phosphate kinase
    Short name:
    HMPP kinase
    Gene namesi
    Name:thiD
    Ordered Locus Names:jhp_0782
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp0782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZL00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ThiD family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    KOiK00941.
    OMAiTNHWAYS.
    OrthoDBiEOG6XWV53.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZL00-1 [UniParc]FASTAAdd to Basket

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    MKVYPQVLSI AGSDSGGGAG IQADLKAFQT FGVFGTSVIT CITAQNTQGV    50
    HGVYPLSVES VKAQILAIRD DFSIKAFKMG ALCNAQIIEC VANALETCDF 100
    GLCVLDPVMV AKNGALLLEE EAILSLKKRL LPKTNLLTPN LPEVYALTGV 150
    QARDDKSASK AMGVLRDLGV KNAVIKGGHT EHFQGEFSND WVFLEDAEFI 200
    LSAKRFNTKN THGTGCTLSS LIVGLLAQGL DLKNAITKAK ELLTIIIQNP 250
    LNIGHGHGPL NLWSIKKHV 269
    Length:269
    Mass (Da):28,768
    Last modified:May 1, 1999 - v1
    Checksum:iC7A170C2A2AB8511
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06362.1.
    PIRiH71889.
    RefSeqiNP_223500.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06362; AAD06362; jhp_0782.
    GeneIDi890106.
    KEGGihpj:jhp0782.
    PATRICi20606297. VBIHelPyl98156_0853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06362.1 .
    PIRi H71889.
    RefSeqi NP_223500.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZL00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06362 ; AAD06362 ; jhp_0782 .
    GeneIDi 890106.
    KEGGi hpj:jhp0782.
    PATRICi 20606297. VBIHelPyl98156_0853.

    Phylogenomic databases

    eggNOGi COG0351.
    KOi K00941.
    OMAi TNHWAYS.
    OrthoDBi EOG6XWV53.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .
    BioCyci HPYL85963:GJB9-795-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiTHID_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZL00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3