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Q9ZL00 (THID_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name=HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name=HMP-P kinase
Short name=HMP-phosphate kinase
Short name=HMPP kinase
Gene names
Name:thiD
Ordered Locus Names:jhp_0782
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Sequence similarities

Belongs to the ThiD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192021

Sites

Binding site451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZL00 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C7A170C2A2AB8511

FASTA26928,768
        10         20         30         40         50         60 
MKVYPQVLSI AGSDSGGGAG IQADLKAFQT FGVFGTSVIT CITAQNTQGV HGVYPLSVES 

        70         80         90        100        110        120 
VKAQILAIRD DFSIKAFKMG ALCNAQIIEC VANALETCDF GLCVLDPVMV AKNGALLLEE 

       130        140        150        160        170        180 
EAILSLKKRL LPKTNLLTPN LPEVYALTGV QARDDKSASK AMGVLRDLGV KNAVIKGGHT 

       190        200        210        220        230        240 
EHFQGEFSND WVFLEDAEFI LSAKRFNTKN THGTGCTLSS LIVGLLAQGL DLKNAITKAK 

       250        260 
ELLTIIIQNP LNIGHGHGPL NLWSIKKHV 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06362.1.
PIRH71889.
RefSeqNP_223500.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZL00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp0782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD06362; AAD06362; jhp_0782.
GeneID890106.
KEGGhpj:jhp0782.
PATRIC20606297. VBIHelPyl98156_0853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0351.
KOK00941.
OMATNHWAYS.
OrthoDBEOG6XWV53.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-795-MONOMER.
UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
InterProIPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHID_HELPJ
AccessionPrimary (citable) accession number: Q9ZL00
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways