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Q9ZKZ2 (GUAC_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase

EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:jhp_0790
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325GMP reductase HAMAP MF_01511
PRO_0000093757

Regions

Nucleotide binding203 – 22624NADP By similarity

Sites

Active site1741Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZKZ2 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 86F1FCF53DE69E91

FASTA32535,845
        10         20         30         40         50         60 
MKVFDYEDVQ LIPNKCIVNS RSECDTTVIL GKHAFKMPIV PANMQTIINE SIAEFLAENG 

        70         80         90        100        110        120 
YFYIMHRFNG SARIPFVKKM KERQLISSIS VGVKKEECLF VEELAKQGLT PDYITIDIAH 

       130        140        150        160        170        180 
GHSNSVIEMI QRIKTRLPET FVIAGNVGTP EAVRELENAG ADATKVGIGP GKVCITKIKT 

       190        200        210        220        230        240 
GFGTGGWQLA ALRWCAKAAR KPIIADGGIR THGDIAKSIR FGATMVMIGS LFAGHEESSG 

       250        260        270        280        290        300 
ETKIENGIAY KEYFGSASEF QKGEKKNIEG KKIWIQHKGS LKNTLIEMHQ DLQSSISYAG 

       310        320 
GRDLEAIRKV DYVIVKNSIF NGDTI 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06382.1.
PIRA71887.
RefSeqNP_223508.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZKZ2.
SMRQ9ZKZ2. Positions 3-320.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZKZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID890104.
GenomeReviewsGene locus jhp_0790 in contig AE001439_GR.
KEGGhpj:jhp0790.
NMPDRfig|85963.1.peg.786.
PATRIC20606315. VBIHelPyl98156_0862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycHPYL85963:JHP0790-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_HELPJ
AccessionPrimary (citable) accession number: Q9ZKZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families