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Q9ZKY2

- LPXB_HELPJ

UniProt

Q9ZKY2 - LPXB_HELPJ

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-814-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:jhp_0801
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Lipid-A-disaccharide synthasePRO_0000190170Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp0801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZKY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZKY2-1 [UniParc]FASTAAdd to Basket

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    MPTILVSALE ASSNIHLEEL RHNLPKDYRF IGVFESKEAL YSPREFSIMG    50
    FRDVIGRLGF LLKAHKEMVQ LAKQADMVLL MDSSSFNIPL AKKIKKQDPH 100
    KKIMYYILPQ VWAWKKWRAK SLEKYCDFLG AILPFEVGYY QKKAQYVGHP 150
    LLDEIKYYKK DIKGETLVFM PGSRKSEIAK MFPLFVKAAQ ILEQNEGFKR 200
    RVLVVPSFFK GLDLKALYGE DIKLFEISYD AHKSLFEAEF AFICSGTATL 250
    EAALIGTPFA LAYRAKTMDF LIARMLVNLH YIGLANIFYN ALNNETPGLG 300
    ESQLHPELIQ HFLSVEGLLK AYEEMDRERY FKESLRLREY LKHGSARKIA 350
    EEMAFLLNLT 360
    Length:360
    Mass (Da):41,566
    Last modified:May 1, 1999 - v1
    Checksum:i44A7504AC031BB2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06363.1.
    PIRiD71888.
    RefSeqiNP_223519.1. NC_000921.1.
    WP_001142216.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06363; AAD06363; jhp_0801.
    GeneIDi890095.
    KEGGihpj:jhp0801.
    PATRICi20606337. VBIHelPyl98156_0873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06363.1 .
    PIRi D71888.
    RefSeqi NP_223519.1. NC_000921.1.
    WP_001142216.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZKY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0801.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06363 ; AAD06363 ; jhp_0801 .
    GeneIDi 890095.
    KEGGi hpj:jhp0801.
    PATRICi 20606337. VBIHelPyl98156_0873.

    Phylogenomic databases

    eggNOGi COG0763.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci HPYL85963:GJB9-814-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiLPXB_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZKY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3