Q9ZKX9 (CDH_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26

Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	jhp_0805

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity HAMAP MF_00319.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198578
Regions
	Transmembrane	7 – 23	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKX9 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: CC612DA76EC2E9F6	FASTA	244	27,450
	10 20 30 40 50 60 MKKAGFLFLA AMAIIVVSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL 70 80 90 100 110 120 KDINGPLQYL LMPTTHISGI ENPLLLDPST PNFFYLSWQA RDFMSKKYGK PIPDYAISLT 130 140 150 160 170 180 INSKKGRSQN HFHIHISCIS LDVRKQLDNN LKNINSRWSP LSGGLNGHKY LARRVTESEL 190 200 210 220 230 240 AQKSPFVMLA KEVPNAHKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC AILR

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06387.1.
PIR	B71885.
RefSeq	NP_223523.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZKX9.
SMR	Q9ZKX9. Positions 25-243.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZKX9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	890088.
GenomeReviews	Gene locus jhp_0805 in contig AE001439_GR.
KEGG	hpj:jhp0805.
NMPDR	fig|85963.1.peg.801.
PATRIC	20606345. VBIHelPyl98156_0877.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2134.
HOGENOM	HBG565233.
OMA	DINGPLQ.
ProtClustDB	PRK05471.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0805-MONOMER.
Family and domain databases
HAMAP	MF_00319. Cdh. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
KO	K01521.
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. Cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_HELPJ

Accession

Primary (citable) accession number: Q9ZKX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program