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Reviewed, UniProtKB/Swiss-Prot Q9ZKX9 (CDH_HELPJ)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase
Gene names
Name: cdh
Ordered Locus Names: jhp_0805
OrganismHelicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319

Pathway

Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319

Subcellular location

Cell inner membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the cdh family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionCDP-diacylglycerol diphosphatase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244CDP-diacylglycerol pyrophosphatase HAMAP MF_00319
PRO_0000198578

Regions

Transmembrane7 – 2317 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZKX9-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: CC612DA76EC2E9F6

FASTA24427,450
        10         20         30         40         50         60 
MKKAGFLFLA AMAIIVVSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL 

        70         80         90        100        110        120 
KDINGPLQYL LMPTTHISGI ENPLLLDPST PNFFYLSWQA RDFMSKKYGK PIPDYAISLT 

       130        140        150        160        170        180 
INSKKGRSQN HFHIHISCIS LDVRKQLDNN LKNINSRWSP LSGGLNGHKY LARRVTESEL 

       190        200        210        220        230        240 
AQKSPFVMLA KEVPNAHKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC 


AILR 

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References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE001439 Genomic DNA. Translation: AAD06387.1.
PIRB71885.
RefSeqNP_223523.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID890088.
GenomeReviewsGene locus jhp_0805 in contig AE001439_GR.
KEGGhpj:jhp0805.
NMPDRfig|85963.1.peg.801.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9ZKX9.
OMAQ9ZKX9. EIQDHEC.

Enzyme and pathway databases

BioCycHPYL85963:JHP0805-MON.
BRENDA3.6.1.26. 295085.

Family and domain databases

HAMAPMF_00319.
[Tree]
InterProIPR003763. CDP-diacylglyc_Pase_bac.
IPR015993. CDP-diacylglyc_Pase_proteobac.
[Graphical view]
PfamPF02611. CDH. 1 hit.
[Graphical view]
PIRSFPIRSF001273. CDH. 1 hit.
TIGRFAMsTIGR00672. cdh. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDH_HELPJ
AccessionPrimary (citable) accession number: Q9ZKX9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents