Reviewed, UniProtKB/Swiss-Prot Q9ZKX5 (CATA_HELPJ)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:	katA
Ordered Locus Names:	jhp_0809

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Catalase		PRO_0000084988
Sites
	Active site	56	1	By similarity
	Active site	129	1	By similarity
	Metal binding	339	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKX5-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 475A07EF6EF9B309	FASTA	505	58,527
	10 20 30 40 50 60 MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI PERVVHAKGS 70 80 90 100 110 120 GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE KGSADAVRDP RGFAMKYYTE 130 140 150 160 170 180 EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK RDPQTNLPNP DMVWDFWSNV PESLYQVTWV 190 200 210 220 230 240 MSDRGIPKSF RHMDGFGSHT FSLINAKGER FWVKFHFETM QGVKHLTNEE AAEVRKYDPD 250 260 270 280 290 300 SNQRDLFDAI AGGDFPKWKM SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN 310 320 330 340 350 360 KNPENYFAEV EQAAFTPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN YPQIPVNRPR 370 380 390 400 410 420 CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP KFNLAHIEKE FEVWNWDYRA 430 440 450 460 470 480 EDSDYYTQPG DYYRSLPADE KERLYDTIGG SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK 490 500 KALEKHQKMM KDMHAKDMHH MKKKK

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD06391.1.
PIR	F71885.
RefSeq	NP_223527.1.
3D structure databases
HSSP	HSSP built from PDB template 2CAG based on UniProtKB P42321.
SMR	Q9ZKX5. Positions 1-491.
ModBase	Search...
Proteomic databases
PRIDE	Q9ZKX5.
Genome annotation databases
GeneID	890086.
GenomeReviews	Gene locus jhp_0809 in contig AE001439_GR.
KEGG	hpj:jhp0809.
NMPDR	fig|85963.1.peg.805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZKX5.
OMA	Q9ZKX5. NCPFRAR.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0809-MON.
BRENDA	1.11.1.6. 295085.
Family and domain databases
InterPro	IPR002226. Catalase. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_HELPJ

Accession

Primary (citable) accession number: Q9ZKX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)