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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway:iacetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-856-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:jhp_0841
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Phosphate acetyltransferasePRO_0000179131Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0841.

Structurei

3D structure databases

ProteinModelPortaliQ9ZKU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 519324Phosphate acetyltransferaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiNPNTSHY.
OrthoDBiEOG6BKJ5W.

Family and domain databases

InterProiIPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZKU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSLWIYPED TEVLGAACKS LLKALKPRYQ KIALFSPISG GCEGFGECES
60 70 80 90 100
LSSLEVHSAI DKQKALELVS TAQEELLFET ILKRYDELQS THDFVINLGY
110 120 130 140 150
APKFFLNALL DLNTILAKHL NAPVVAVAQT SLDHLKAMHS HILKKEAPFA
160 170 180 190 200
IGLFVGETLE KPHFLSASLC KQQCELEASA IENLLQTKSE IITPLAFQRS
210 220 230 240 250
LEKKAKKQIK KVVLPESEDE RILKAAHRLN LMGAVGLILL GDKEAINSQA
260 270 280 290 300
KNLNLNLENV EIINPNTSHY REEFAKSLYE LRKSKGLSEQ EAERLALDKT
310 320 330 340 350
YFATMLVHLG YAHAMVSGVN HTTAETIRPA LQIIKTKPGV SLVSSVFLMC
360 370 380 390 400
LDTQVFVFGD CAIIPNPSPK ELAEIATTSA QTAKQFNIAP KVALLSYATG
410 420 430 440 450
NSAQGEMIDK INEALTIVQK LDPQLEIDGP LQFDASIDKG VAKKKMPNSQ
460 470 480 490 500
VAGQASVFIF PDLNAGNIAY KAVQRSAKAV AIGPILQGLN KPINDLSRGA
510
LVEDIVNTVL ISAIQAQDY
Length:519
Mass (Da):56,738
Last modified:May 1, 1999 - v1
Checksum:i3E5A71FC8BBBAD37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06419.1.
PIRiD71881.
RefSeqiWP_001191463.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06419; AAD06419; jhp_0841.
KEGGihpj:jhp0841.
PATRICi20606429. VBIHelPyl98156_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06419.1.
PIRiD71881.
RefSeqiWP_001191463.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZKU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp0841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06419; AAD06419; jhp_0841.
KEGGihpj:jhp0841.
PATRICi20606429. VBIHelPyl98156_0917.

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiNPNTSHY.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciHPYL85963:GJB9-856-MONOMER.

Family and domain databases

InterProiIPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiPTAS_HELPJ
AccessioniPrimary (citable) accession number: Q9ZKU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.