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Q9ZKD8

- DHE4_HELPJ

UniProt

Q9ZKD8 - DHE4_HELPJ

Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei109 – 1091SubstrateBy similarity
    Binding sitei112 – 1121SubstrateBy similarity
    Active sitei124 – 1241Proton donorPROSITE-ProRule annotation
    Binding sitei163 – 1631Substrate; via carbonyl oxygenBy similarity
    Sitei164 – 1641Important for catalysisBy similarity
    Binding sitei207 – 2071NADPBy similarity
    Binding sitei238 – 2381NADPBy similarity
    Binding sitei381 – 3811SubstrateBy similarity

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

    GO - Biological processi

    1. glutamate biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-1026-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
    Short name:
    NADP-GDH
    Gene namesi
    Name:gdhA
    Ordered Locus Names:jhp_1001
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448NADP-specific glutamate dehydrogenasePRO_0000182772Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZKD8.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    IntActiQ9ZKD8. 1 interaction.
    STRINGi85963.jhp1001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZKD8.
    SMRiQ9ZKD8. Positions 2-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    KOiK00262.
    OMAiIMLDIHA.
    OrthoDBiEOG65XN4D.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZKD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAVLERL    50
    IEPEREIFFR VCWLDDNHQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES 100
    VIKFLGFEQV LKNSLTTLAM GGAKGGSDFD PKEKSEHEIM RFCQAFMNEL 150
    YRHIGATTDV PAGDIGVGER EIGYLFGQYK KLVNRFEGVL TGKGLTYGGS 200
    LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA IYTIEKLLQI 250
    GAKPVTASDS NGMIYDKDGI DLELLKEIKE ARRGRIKEYA LEKTSAKYTP 300
    TENYPKGGNA IWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM 350
    PSSNEAIELF LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD 400
    AKLHHIMKEI YKNVSQTAKE FKDPTNFVLG ANIAGFRKVA SAMIAQGV 448
    Length:448
    Mass (Da):49,491
    Last modified:May 1, 1999 - v1
    Checksum:i1E25BAC991C4FCCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06574.1.
    PIRiF71862.
    RefSeqiNP_223718.1. NC_000921.1.
    WP_000289195.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06574; AAD06574; jhp_1001.
    GeneIDi889639.
    KEGGihpj:jhp1001.
    PATRICi20606792. VBIHelPyl98156_1089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06574.1 .
    PIRi F71862.
    RefSeqi NP_223718.1. NC_000921.1.
    WP_000289195.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZKD8.
    SMRi Q9ZKD8. Positions 2-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZKD8. 1 interaction.
    STRINGi 85963.jhp1001.

    Proteomic databases

    PRIDEi Q9ZKD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06574 ; AAD06574 ; jhp_1001 .
    GeneIDi 889639.
    KEGGi hpj:jhp1001.
    PATRICi 20606792. VBIHelPyl98156_1089.

    Phylogenomic databases

    eggNOGi COG0334.
    KOi K00262.
    OMAi IMLDIHA.
    OrthoDBi EOG65XN4D.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-1026-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiDHE4_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZKD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3