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Q9ZKD8

- DHE4_HELPJ

UniProt

Q9ZKD8 - DHE4_HELPJ

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Protein
NADP-specific glutamate dehydrogenase
Gene
gdhA, jhp_1001
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Substrate By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei112 – 1121Substrate By similarity
Active sitei124 – 1241Proton donor By similarity
Binding sitei163 – 1631Substrate; via carbonyl oxygen By similarity
Sitei164 – 1641Important for catalysis By similarity
Binding sitei207 – 2071NADP By similarity
Binding sitei238 – 2381NADP By similarity
Binding sitei381 – 3811Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:jhp_1001
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448NADP-specific glutamate dehydrogenase
PRO_0000182772Add
BLAST

Proteomic databases

PRIDEiQ9ZKD8.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

IntActiQ9ZKD8. 1 interaction.
STRINGi85963.jhp1001.

Structurei

3D structure databases

ProteinModelPortaliQ9ZKD8.
SMRiQ9ZKD8. Positions 2-448.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
KOiK00262.
OMAiIMLDIHA.
OrthoDBiEOG65XN4D.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZKD8-1 [UniParc]FASTAAdd to Basket

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MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAVLERL    50
IEPEREIFFR VCWLDDNHQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES 100
VIKFLGFEQV LKNSLTTLAM GGAKGGSDFD PKEKSEHEIM RFCQAFMNEL 150
YRHIGATTDV PAGDIGVGER EIGYLFGQYK KLVNRFEGVL TGKGLTYGGS 200
LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA IYTIEKLLQI 250
GAKPVTASDS NGMIYDKDGI DLELLKEIKE ARRGRIKEYA LEKTSAKYTP 300
TENYPKGGNA IWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM 350
PSSNEAIELF LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD 400
AKLHHIMKEI YKNVSQTAKE FKDPTNFVLG ANIAGFRKVA SAMIAQGV 448
Length:448
Mass (Da):49,491
Last modified:May 1, 1999 - v1
Checksum:i1E25BAC991C4FCCB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06574.1.
PIRiF71862.
RefSeqiNP_223718.1. NC_000921.1.
WP_000289195.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06574; AAD06574; jhp_1001.
GeneIDi889639.
KEGGihpj:jhp1001.
PATRICi20606792. VBIHelPyl98156_1089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06574.1 .
PIRi F71862.
RefSeqi NP_223718.1. NC_000921.1.
WP_000289195.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZKD8.
SMRi Q9ZKD8. Positions 2-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZKD8. 1 interaction.
STRINGi 85963.jhp1001.

Proteomic databases

PRIDEi Q9ZKD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06574 ; AAD06574 ; jhp_1001 .
GeneIDi 889639.
KEGGi hpj:jhp1001.
PATRICi 20606792. VBIHelPyl98156_1089.

Phylogenomic databases

eggNOGi COG0334.
KOi K00262.
OMAi IMLDIHA.
OrthoDBi EOG65XN4D.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-1026-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiDHE4_HELPJ
AccessioniPrimary (citable) accession number: Q9ZKD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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