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Q9ZKC3 (RIR2_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:jhp_1016
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190481

Sites

Active site1271 By similarity
Metal binding891Iron 1 By similarity
Metal binding1201Iron 1 By similarity
Metal binding1201Iron 2 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1851Iron 2 By similarity
Metal binding2191Iron 2 By similarity
Metal binding2221Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZKC3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 248E7E1AE1E4CD74

FASTA34139,528
        10         20         30         40         50         60 
MEVSRKKIYN PNSTESVNER KIFGGNPTSM FDLNKIKYQW ADHLWKTMLA NTWFAEEVSM 

        70         80         90        100        110        120 
NDDKRDYLKL SAEEKIGYDR ALAQLIFMDS LQANNLIDNI NPFITSPEIN LCLVRQAYEE 

       130        140        150        160        170        180 
ALHSHAYAVM VESISANTEE IYDMWRNDMQ LKSKNDYIAQ VYMELAKNPT EENILKALFA 

       190        200        210        220        230        240 
NQILEGIYFY SGFSYFYTLA RSGKMLGSAQ MIRFIQRDEV THLILFQNMI NALRNERADL 

       250        260        270        280        290        300 
FTPQLINEVI EMFKKAVEIE ASWGDYITQG KILGLTSSLI EQYIQFLADS RLSKVGIAKV 

       310        320        330        340 
YGVQHPIKWV ESFSSFNEQR SNFFEARVSN YAKGSVSFDD F 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06604.1.
PIRC71858.
RefSeqNP_223733.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZKC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp1016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD06604; AAD06604; jhp_1016.
GeneID889653.
KEGGhpj:jhp1016.
PATRIC20606824. VBIHelPyl98156_1104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMAWIETWAF.
OrthoDBEOG6J48J7.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-1042-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFPIRSF000355. NrdB. 1 hit.
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_HELPJ
AccessionPrimary (citable) accession number: Q9ZKC3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways