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Q9ZKB5

- HCPC_HELPJ

UniProt

Q9ZKB5 - HCPC_HELPJ

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Protein
Putative beta-lactamase HcpC
Gene
hcpC, jhp_1024
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpC (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein C
Gene namesi
Name:hcpC
Ordered Locus Names:jhp_1024
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 290265Putative beta-lactamase HcpC
PRO_0000013197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 64 Reviewed prediction
Disulfide bondi92 ↔ 100 Reviewed prediction
Disulfide bondi128 ↔ 136 Reviewed prediction
Disulfide bondi164 ↔ 172 Reviewed prediction
Disulfide bondi200 ↔ 208 Reviewed prediction
Disulfide bondi236 ↔ 244 Reviewed prediction
Disulfide bondi272 ↔ 280 Reviewed prediction

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1024.

Structurei

3D structure databases

ProteinModelPortaliQ9ZKB5.
SMRiQ9ZKB5. Positions 28-290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6234TPR 1
Add
BLAST
Repeati64 – 9835TPR 2
Add
BLAST
Repeati100 – 13334TPR 3
Add
BLAST
Repeati134 – 17037TPR 4
Add
BLAST
Repeati172 – 20534TPR 5
Add
BLAST
Repeati206 – 24237TPR 6
Add
BLAST
Repeati244 – 27835TPR 7
Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiKDFTQAK.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZKB5-1 [UniParc]FASTAAdd to Basket

« Hide

MLENVKKSLF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEQDFTQAKK    50
YFEKACDLKE NSGCFNLGVL YYQGHGVEKN LKKAASFYSK ACDLNYSNGC 100
HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT 150
RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC 200
DLKDSPGCFN AGNMYHHGEG AAKNFKEALA RYSKACELEN GGGCFNLGAM 250
QYNGEGATRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV 290
Length:290
Mass (Da):31,527
Last modified:May 1, 1999 - v1
Checksum:i0F5AC40DAEA2427D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06595.1.
PIRiC71859.
RefSeqiNP_223741.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06595; AAD06595; jhp_1024.
GeneIDi889662.
KEGGihpj:jhp1024.
PATRICi20606842. VBIHelPyl98156_1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06595.1 .
PIRi C71859.
RefSeqi NP_223741.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZKB5.
SMRi Q9ZKB5. Positions 28-290.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85963.jhp1024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06595 ; AAD06595 ; jhp_1024 .
GeneIDi 889662.
KEGGi hpj:jhp1024.
PATRICi 20606842. VBIHelPyl98156_1111.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi KDFTQAK.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-1051-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00671. SEL1. 7 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPC_HELPJ
AccessioniPrimary (citable) accession number: Q9ZKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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