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Q9ZKB5 (HCPC_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpC

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein C
Gene names
Name:hcpC
Ordered Locus Names:jhp_1024
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 7 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 290265Putative beta-lactamase HcpC
PRO_0000013197

Regions

Repeat29 – 6234TPR 1
Repeat64 – 9835TPR 2
Repeat100 – 13334TPR 3
Repeat134 – 17037TPR 4
Repeat172 – 20534TPR 5
Repeat206 – 24237TPR 6
Repeat244 – 27835TPR 7

Amino acid modifications

Disulfide bond56 ↔ 64 Potential
Disulfide bond92 ↔ 100 Potential
Disulfide bond128 ↔ 136 Potential
Disulfide bond164 ↔ 172 Potential
Disulfide bond200 ↔ 208 Potential
Disulfide bond236 ↔ 244 Potential
Disulfide bond272 ↔ 280 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZKB5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0F5AC40DAEA2427D

FASTA29031,527
        10         20         30         40         50         60 
MLENVKKSLF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEQDFTQAKK YFEKACDLKE 

        70         80         90        100        110        120 
NSGCFNLGVL YYQGHGVEKN LKKAASFYSK ACDLNYSNGC HLLGNLYYSG QGVSQNTNKA 

       130        140        150        160        170        180 
LQYYSKACDL KYAEGCASLG GIYHDGKVVT RDFKKAVEYF TKACDLNDGD GCTILGSLYD 

       190        200        210        220        230        240 
AGRGTPKDLK KALASYDKAC DLKDSPGCFN AGNMYHHGEG AAKNFKEALA RYSKACELEN 

       250        260        270        280        290 
GGGCFNLGAM QYNGEGATRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06595.1.
PIRC71859.
RefSeqNP_223741.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZKB5.
SMRQ9ZKB5. Positions 28-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp1024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD06595; AAD06595; jhp_1024.
GeneID889662.
KEGGhpj:jhp1024.
PATRIC20606842. VBIHelPyl98156_1111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAACDLNDG.
OrthoDBEOG6TJ7WZ.
ProtClustDBCLSK495918.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-1051-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEPS50005. TPR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPC_HELPJ
AccessionPrimary (citable) accession number: Q9ZKB5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families