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Protein

Putative beta-lactamase HcpC

Gene

hcpC

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpC (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein C
Gene namesi
Name:hcpC
Ordered Locus Names:jhp_1024
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 290265Putative beta-lactamase HcpCPRO_0000013197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 64Sequence Analysis
Disulfide bondi92 ↔ 100Sequence Analysis
Disulfide bondi128 ↔ 136Sequence Analysis
Disulfide bondi164 ↔ 172Sequence Analysis
Disulfide bondi200 ↔ 208Sequence Analysis
Disulfide bondi236 ↔ 244Sequence Analysis
Disulfide bondi272 ↔ 280Sequence Analysis

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1024.

Structurei

3D structure databases

ProteinModelPortaliQ9ZKB5.
SMRiQ9ZKB5. Positions 28-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6234TPR 1Add
BLAST
Repeati64 – 9835TPR 2Add
BLAST
Repeati100 – 13334TPR 3Add
BLAST
Repeati134 – 17037TPR 4Add
BLAST
Repeati172 – 20534TPR 5Add
BLAST
Repeati206 – 24237TPR 6Add
BLAST
Repeati244 – 27835TPR 7Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiDPAHETQ.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZKB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENVKKSLF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEQDFTQAKK
60 70 80 90 100
YFEKACDLKE NSGCFNLGVL YYQGHGVEKN LKKAASFYSK ACDLNYSNGC
110 120 130 140 150
HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT
160 170 180 190 200
RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC
210 220 230 240 250
DLKDSPGCFN AGNMYHHGEG AAKNFKEALA RYSKACELEN GGGCFNLGAM
260 270 280 290
QYNGEGATRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV
Length:290
Mass (Da):31,527
Last modified:May 1, 1999 - v1
Checksum:i0F5AC40DAEA2427D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06595.1.
PIRiC71859.
RefSeqiWP_000892769.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06595; AAD06595; jhp_1024.
KEGGihpj:jhp1024.
PATRICi20606842. VBIHelPyl98156_1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06595.1.
PIRiC71859.
RefSeqiWP_000892769.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZKB5.
SMRiQ9ZKB5. Positions 28-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp1024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06595; AAD06595; jhp_1024.
KEGGihpj:jhp1024.
PATRICi20606842. VBIHelPyl98156_1111.

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiDPAHETQ.
OrthoDBiEOG6TJ7WZ.

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1051-MONOMER.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 6 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPC_HELPJ
AccessioniPrimary (citable) accession number: Q9ZKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.