Q9ZKB5 (HCPC_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative beta-lactamase HcpC
EC=3.5.2.6

Alternative name(s):
Cysteine-rich protein C

Gene names

Name:	hcpC
Ordered Locus Names:	jhp_1024

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.
Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the hcp beta-lactamase family. Contains 7 TPR repeats.

Ontologies

Keywords
Biological process	Antibiotic resistance
Cellular component	Secreted
Domain	Repeat Signal TPR repeat
Molecular function	Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 290	265	Putative beta-lactamase HcpC		PRO_0000013197
Regions
	Repeat	29 – 62	34	TPR 1
	Repeat	64 – 98	35	TPR 2
	Repeat	100 – 133	34	TPR 3
	Repeat	134 – 170	37	TPR 4
	Repeat	172 – 205	34	TPR 5
	Repeat	206 – 242	37	TPR 6
	Repeat	244 – 278	35	TPR 7
Amino acid modifications
	Disulfide bond	56 ↔ 64		Potential
	Disulfide bond	92 ↔ 100		Potential
	Disulfide bond	128 ↔ 136		Potential
	Disulfide bond	164 ↔ 172		Potential
	Disulfide bond	200 ↔ 208		Potential
	Disulfide bond	236 ↔ 244		Potential
	Disulfide bond	272 ↔ 280		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKB5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0F5AC40DAEA2427D	FASTA	290	31,527
	10 20 30 40 50 60 MLENVKKSLF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEQDFTQAKK YFEKACDLKE 70 80 90 100 110 120 NSGCFNLGVL YYQGHGVEKN LKKAASFYSK ACDLNYSNGC HLLGNLYYSG QGVSQNTNKA 130 140 150 160 170 180 LQYYSKACDL KYAEGCASLG GIYHDGKVVT RDFKKAVEYF TKACDLNDGD GCTILGSLYD 190 200 210 220 230 240 AGRGTPKDLK KALASYDKAC DLKDSPGCFN AGNMYHHGEG AAKNFKEALA RYSKACELEN 250 260 270 280 290 GGGCFNLGAM QYNGEGATRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06595.1.
PIR	C71859.
RefSeq	NP_223741.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZKB5.
SMR	Q9ZKB5. Positions 28-290.
ModBase	Search...
Protein-protein interaction databases
STRING	85963.jhp1024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD06595; AAD06595; jhp_1024.
GeneID	889662.
KEGG	hpj:jhp1024.
PATRIC	20606842. VBIHelPyl98156_1111.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0790.
KO	K07126.
OMA	YHHGEGA.
ProtClustDB	CLSK495918.
Enzyme and pathway databases
BioCyc	HPYL85963:GJB9-1051-MONOMER.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR006597. Sel1-like. IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF08238. Sel1. 6 hits. PF07719. TPR_2. 1 hit. [Graphical view]
SMART	SM00671. SEL1. 7 hits. [Graphical view]
PROSITE	PS50005. TPR. 1 hit. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HCPC_HELPJ

Accession

Primary (citable) accession number: Q9ZKB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program