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Q9ZKB5

- HCPC_HELPJ

UniProt

Q9ZKB5 - HCPC_HELPJ

Protein

Putative beta-lactamase HcpC

Gene

hcpC

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-1051-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-lactamase HcpC (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein C
    Gene namesi
    Name:hcpC
    Ordered Locus Names:jhp_1024
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 290265Putative beta-lactamase HcpCPRO_0000013197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 64Sequence Analysis
    Disulfide bondi92 ↔ 100Sequence Analysis
    Disulfide bondi128 ↔ 136Sequence Analysis
    Disulfide bondi164 ↔ 172Sequence Analysis
    Disulfide bondi200 ↔ 208Sequence Analysis
    Disulfide bondi236 ↔ 244Sequence Analysis
    Disulfide bondi272 ↔ 280Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp1024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZKB5.
    SMRiQ9ZKB5. Positions 28-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 6234TPR 1Add
    BLAST
    Repeati64 – 9835TPR 2Add
    BLAST
    Repeati100 – 13334TPR 3Add
    BLAST
    Repeati134 – 17037TPR 4Add
    BLAST
    Repeati172 – 20534TPR 5Add
    BLAST
    Repeati206 – 24237TPR 6Add
    BLAST
    Repeati244 – 27835TPR 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 7 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiKDFTQAK.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF08238. Sel1. 6 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00671. SEL1. 7 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZKB5-1 [UniParc]FASTAAdd to Basket

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    MLENVKKSLF RVLCLGALCL GGLMAEQDPK ELVGLGAKSY KEQDFTQAKK    50
    YFEKACDLKE NSGCFNLGVL YYQGHGVEKN LKKAASFYSK ACDLNYSNGC 100
    HLLGNLYYSG QGVSQNTNKA LQYYSKACDL KYAEGCASLG GIYHDGKVVT 150
    RDFKKAVEYF TKACDLNDGD GCTILGSLYD AGRGTPKDLK KALASYDKAC 200
    DLKDSPGCFN AGNMYHHGEG AAKNFKEALA RYSKACELEN GGGCFNLGAM 250
    QYNGEGATRN EKQAIENFKK GCKLGAKGAC DILKQLKIKV 290
    Length:290
    Mass (Da):31,527
    Last modified:May 1, 1999 - v1
    Checksum:i0F5AC40DAEA2427D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06595.1.
    PIRiC71859.
    RefSeqiNP_223741.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06595; AAD06595; jhp_1024.
    GeneIDi889662.
    KEGGihpj:jhp1024.
    PATRICi20606842. VBIHelPyl98156_1111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06595.1 .
    PIRi C71859.
    RefSeqi NP_223741.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZKB5.
    SMRi Q9ZKB5. Positions 28-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp1024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06595 ; AAD06595 ; jhp_1024 .
    GeneIDi 889662.
    KEGGi hpj:jhp1024.
    PATRICi 20606842. VBIHelPyl98156_1111.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi KDFTQAK.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-1051-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF08238. Sel1. 6 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00671. SEL1. 7 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiHCPC_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZKB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3