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Q9ZKB2

- G6PD_HELPJ

UniProt

Q9ZKB2 - G6PD_HELPJ

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, jhp_1027
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADP By similarity
Binding sitei135 – 1351NADP By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei220 – 2201Substrate By similarity
Active sitei225 – 2251Proton acceptor By similarity
Binding sitei311 – 3111Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1054-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:jhp_1027
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068124Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1027.

Structurei

3D structure databases

ProteinModelPortaliQ9ZKB2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiIETHPRE.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZKB2-1 [UniParc]FASTAAdd to Basket

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MLDFDLVLFG ATGDLAMRKL FVSLYEIYIH YGFKNDSRII ASGRKELSNE    50
EFLALLCEKT QLHSREKGEE FLTHISYLRV RLDNPKDFEE LSKIATNNKP 100
LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS 150
ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY 200
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRQEKIK 250
VLKTLQPPKD FTKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 300
KGVPFYLKHA KKMPRNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL 350
ILETHNKQEF LQPYAKLLYD AIPNNHYNFA HQLELEASWV FIDTLIEGFI 400
NNATPLYSYE SHNLNESEFL KPLYQ 425
Length:425
Mass (Da):49,456
Last modified:May 1, 1999 - v1
Checksum:i3A7FDD9200DB0D50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06598.1.
PIRiF71859.
RefSeqiNP_223744.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06598; AAD06598; jhp_1027.
GeneIDi889664.
KEGGihpj:jhp1027.
PATRICi20606848. VBIHelPyl98156_1114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06598.1 .
PIRi F71859.
RefSeqi NP_223744.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZKB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp1027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06598 ; AAD06598 ; jhp_1027 .
GeneIDi 889664.
KEGGi hpj:jhp1027.
PATRICi 20606848. VBIHelPyl98156_1114.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi IETHPRE.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci HPYL85963:GJB9-1054-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiG6PD_HELPJ
AccessioniPrimary (citable) accession number: Q9ZKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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