Reviewed, UniProtKB/Swiss-Prot Q9ZKB2 (G6PD_HELPJ)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	jhp_1027

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068124
Sites
	Active site	225	1	Proton acceptor By similarity
	Binding site	12	1	NADP By similarity
	Binding site	44	1	NADP By similarity
	Binding site	165	1	Substrate By similarity
	Binding site	169	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKB2-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3A7FDD9200DB0D50	FASTA	425	49,456
	10 20 30 40 50 60 MLDFDLVLFG ATGDLAMRKL FVSLYEIYIH YGFKNDSRII ASGRKELSNE EFLALLCEKT 70 80 90 100 110 120 QLHSREKGEE FLTHISYLRV RLDNPKDFEE LSKIATNNKP LIFYFSISPS FFATTAQNLA 130 140 150 160 170 180 QNALNHANTR LILEKPLGHD LKTCKEIFQS ISAFFKEEQI FRIDHYLGKK GVQNILELRL 190 200 210 220 230 240 NNPILNILWD QISAVEICVY ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND 250 260 270 280 290 300 LKDLRQEKIK VLKTLQPPKD FTKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 310 320 330 340 350 360 KGVPFYLKHA KKMPRNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL ILETHNKQEF 370 380 390 400 410 420 LQPYAKLLYD AIPNNHYNFA HQLELEASWV FIDTLIEGFI NNATPLYSYE SHNLNESEFL KPLYQ

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD06598.1.
PIR	F71859.
RefSeq	NP_223744.1.
3D structure databases
HSSP	HSSP built from PDB template 1DPG based on UniProtKB P11411.
ModBase	Search...
Genome annotation databases
GeneID	889664.
GenomeReviews	Gene locus jhp_1027 in contig AE001439_GR.
KEGG	hpj:jhp1027.
NMPDR	fig|85963.1.peg.1022.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZKB2.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP1027-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

G6PD_HELPJ

Accession

Primary (citable) accession number: Q9ZKB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)