Q9ZKB2 (G6PD_HELPJ) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glucose-6-phosphate 1-dehydrogenase Short name=G6PD EC=1.1.1.49 | ||||
| Gene names |
| ||||
| Organism | Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 85963 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the glucose-6-phosphate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 425 | 425 | Glucose-6-phosphate 1-dehydrogenase | PRO_0000068124 | |||||
Sites | |||||||||
| Active site | 225 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 12 | 1 | NADP By similarity | ||||||
| Binding site | 44 | 1 | NADP By similarity | ||||||
| Binding site | 165 | 1 | Substrate By similarity | ||||||
| Binding site | 169 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. Trust T.J.Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001439 Genomic DNA. Translation: AAD06598.1. |
| PIR | F71859. |
| RefSeq | NP_223744.1. NC_000921.1. |
3D structure databases | |
| ProteinModelPortal | Q9ZKB2. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9ZKB2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 889664. |
| GenomeReviews | Gene locus jhp_1027 in contig AE001439_GR. |
| KEGG | hpj:jhp1027. |
| NMPDR | fig|85963.1.peg.1022. |
| PATRIC | 20606848. VBIHelPyl98156_1114. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0364. |
| HOGENOM | HBG322449. |
| OMA | DNIYENT. |
| PhylomeDB | Q9ZKB2. |
| ProtClustDB | PRK05722. |
Enzyme and pathway databases | |
| BioCyc | HPYL85963:JHP1027-MONOMER. |
Family and domain databases | |
| InterPro | IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00036. |
| PANTHER | PTHR23429. G6PDH. 1 hit. |
| Pfam | PF02781. G6PD_C. 2 hits. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000110. G6PD. 1 hit. |
| PRINTS | PR00079. G6PDHDRGNASE. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PD_HELPJ | ||||||||
| Accession | Primary (citable) accession number: Q9ZKB2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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