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Q9ZKB2

- G6PD_HELPJ

UniProt

Q9ZKB2 - G6PD_HELPJ

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441NADPUniRule annotation
    Binding sitei135 – 1351NADPUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei220 – 2201SubstrateUniRule annotation
    Active sitei225 – 2251Proton acceptorUniRule annotation
    Binding sitei311 – 3111SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-1054-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:jhp_1027
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Glucose-6-phosphate 1-dehydrogenasePRO_0000068124Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp1027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZKB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiIETHPRE.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZKB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDFDLVLFG ATGDLAMRKL FVSLYEIYIH YGFKNDSRII ASGRKELSNE    50
    EFLALLCEKT QLHSREKGEE FLTHISYLRV RLDNPKDFEE LSKIATNNKP 100
    LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS 150
    ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY 200
    ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRQEKIK 250
    VLKTLQPPKD FTKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 300
    KGVPFYLKHA KKMPRNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL 350
    ILETHNKQEF LQPYAKLLYD AIPNNHYNFA HQLELEASWV FIDTLIEGFI 400
    NNATPLYSYE SHNLNESEFL KPLYQ 425
    Length:425
    Mass (Da):49,456
    Last modified:May 1, 1999 - v1
    Checksum:i3A7FDD9200DB0D50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06598.1.
    PIRiF71859.
    RefSeqiNP_223744.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06598; AAD06598; jhp_1027.
    GeneIDi889664.
    KEGGihpj:jhp1027.
    PATRICi20606848. VBIHelPyl98156_1114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06598.1 .
    PIRi F71859.
    RefSeqi NP_223744.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZKB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp1027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06598 ; AAD06598 ; jhp_1027 .
    GeneIDi 889664.
    KEGGi hpj:jhp1027.
    PATRICi 20606848. VBIHelPyl98156_1114.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi IETHPRE.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci HPYL85963:GJB9-1054-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiG6PD_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZKB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3