Q9ZKB1 (6PGL_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	jhp_1028

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	6-phosphogluconolactonase		PRO_0000090096

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKB1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 7BB329FBEF187E3C	FASTA	227	25,636
	10 20 30 40 50 60 MGYQLFEFEN LEDCHKALIE RFKEFFNAAL KKHHQVSVAF SGGRSPISLL QKLSVLDLKW 70 80 90 100 110 120 HECLISLVDE RIIEASHEDS NAKLLHDYLL QNNALKASFT PLLPEKISGD TNELLDFANQ 130 140 150 160 170 180 HFKQPHLAIL GMGTDGHTAS LFPETSAFLN EEKENIVLTK PTNAPYERLS MSINALENCE 190 200 210 220 KLFLSISGVE KRGVLEKALK ENAPYSLPIA RILHSKKVTT EVFYAKN

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06599.1.
PIR	G71859.
RefSeq	NP_223745.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZKB1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZKB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	889665.
GenomeReviews	Gene locus jhp_1028 in contig AE001439_GR.
KEGG	hpj:jhp1028.
NMPDR	fig|85963.1.peg.1023.
PATRIC	20606850. VBIHelPyl98156_1115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0363.
HOGENOM	HBG725991.
OMA	NAPYERL.
PhylomeDB	Q9ZKB1.
ProtClustDB	CLSK872499.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP1028-MONOMER.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
KO	K01057.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. Pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_HELPJ

Accession

Primary (citable) accession number: Q9ZKB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program