Q9ZKB0 (GLK_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	jhp_1029

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00524.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Glucokinase HAMAP-Rule MF_00524		PRO_0000215129
Regions
	Nucleotide binding	12 – 17	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZKB0 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9B0F5466A8C1332D	FASTA	336	36,759
	10 20 30 40 50 60 MPKTETYPRL LADIGGTNAR FGLEVAPRQI ECVEVLRCED FESLSDAVRF YLSKCKESLK 70 80 90 100 110 120 LHPIYGSFAV ATPIMGDFVQ MTNNHWTFSI ETTRQCLNLK KLLVINDFVA QAYAISAMQE 130 140 150 160 170 180 NDLAQIGGIK CEINAPKAIL GPGTGLGVST LIQNSDGSLK VLPGEGGHVS FAPFDDLEIL 190 200 210 220 230 240 VWQYARSKFN HVSAERFLSG SGLVLIYEAL SKRKGLEKVA KLSKAELTPQ IISERALNGD 250 260 270 280 290 300 YPICRLTLDT FCSMLGTLAA DVALTLGARG GVYLCGGIIP RFIDYFKTSP FRARFETKGR 310 320 330 MGAFLASIPV HVVMKKTPGL DGAGIALENY LLHDRI

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06594.1.
PIR	H71859.
RefSeq	NP_223746.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZKB0.
ModBase	Search...
Protein-protein interaction databases
STRING	85963.jhp1029.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD06594; AAD06594; jhp_1029.
GeneID	889666.
KEGG	hpj:jhp1029.
PATRIC	20606852. VBIHelPyl98156_1116.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0837.
KO	K00845.
OMA	FADKGCM.
ProtClustDB	PRK00292.
Enzyme and pathway databases
BioCyc	HPYL85963:GJB9-1056-MONOMER.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_HELPJ

Accession

Primary (citable) accession number: Q9ZKB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program