Q9ZK56 (P5CR_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	jhp_1085

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Pyrroline-5-carboxylate reductase		PRO_0000187292

Sequences

	Sequence		Length	Mass (Da)
	Q9ZK56 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9F219D8DB196F92A	FASTA	257	28,203
	10 20 30 40 50 60 MEILQFIGYG NMAQAILEGS HEILSKRFIL EITGRNPEKI APFLQEKNIQ AQIVPYKDAI 70 80 90 100 110 120 DIHQKFVFLL FKPYNLKDFN YQGQAKSVLS ALAGVNFEAL SNAINSLHYL KCMPNIASKF 130 140 150 160 170 180 ALSSTAVCEK SVAPSISEKA LNIIESFGNC VRVGNEEQVD SSVATNGSAL AFLSLVASSL 190 200 210 220 230 240 KDAGIREGLN AKDSLELVKM SFKGFAKLLE KERPEMIIEQ ICTPKGATIE GLSVLEKKGV 250 RGAFIKACHE SVKKMRL

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06667.1.
PIR	E71850.
RefSeq	NP_223802.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZK56.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZK56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	889724.
GenomeReviews	Gene locus jhp_1085 in contig AE001439_GR.
KEGG	hpj:jhp1085.
NMPDR	fig|85963.1.peg.1080.
PATRIC	20606978. VBIHelPyl98156_1178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0345.
HOGENOM	HBG726602.
OMA	ACHESVK.
ProtClustDB	PRK11880.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP1085-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_HELPJ

Accession

Primary (citable) accession number: Q9ZK56

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program