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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi484MagnesiumUniRule annotation1
Metal bindingi490MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-1224-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:jhp_1136
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296801 – 688Polyribonucleotide nucleotidyltransferaseAdd BLAST688

Proteomic databases

PRIDEiQ9ZK11

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1136

Structurei

3D structure databases

ProteinModelPortaliQ9ZK11
SMRiQ9ZK11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini550 – 609KHUniRule annotationAdd BLAST60
Domaini626 – 688S1 motifUniRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZK11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFITINSGN RTEEFALKQV AKQATSSLMY RLGKTLILAS VCVEREPVSE
60 70 80 90 100
DFLPLVVQFL EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTLRPLFP
110 120 130 140 150
KDYRYPTQIT LMVLNHDIEN DLQVSALNAA SATLFLAHIA PIKSVSACRI
160 170 180 190 200
ARVDNEFIIN PSASLLNQSS LDLFVSGTKE SLNMIEMRSL GQKLNALEEP
210 220 230 240 250
LMLEALELAQ KSLKETCALY EEAFTPYQNE LLFKEGEGIV LNERLLDLLK
260 270 280 290 300
NQYFDEIIKG IESSALSERE NVFKEVAKKI SEAHSEFSLE EIELSLEKVK
310 320 330 340 350
KTEIRRMIIQ DKIRPDKRAL EEVRPISIES NLLPMAHSSI LFTRGQTQSL
360 370 380 390 400
VVGVLGMDND AQTHENLEHK APIKERFMFH YNFPPFCVGE ASSIGATSRR
410 420 430 440 450
ELGHGNLAKR ALETSIKNKE QVIRLVSEIL ESNGSSSMAS VCAGSLALYA
460 470 480 490 500
SGVEIHDLVA GVAMGMVSER QDHAILSDIS GLEDAEGDMD FKIAGNLEGI
510 520 530 540 550
TAMQMDTKMS GIQLEVLYQA LLQAKRARKH ILKIMHEAKE KIVINFSHLP
560 570 580 590 600
QTEIFNVAPD KIIEIIGQGG RVIKEIVEKF EVKIDLNTPS GEVKIMGNKE
610 620 630 640 650
RVLKTKEFIL NYLHSLDQEL EQYAIDEVLE AQVKRIVDFG AFLSLPKGGE
660 670 680
GLLRKQNMDK CQVILKEGDS IRCRVISFNK GKIALDLA
Length:688
Mass (Da):76,938
Last modified:May 1, 1999 - v1
Checksum:i09FB3D59A7F5E3B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06718.1
PIRiE71845
RefSeqiWP_000345782.1, NC_000921.1

Genome annotation databases

EnsemblBacteriaiAAD06718; AAD06718; jhp_1136
KEGGihpj:jhp_1136

Similar proteinsi

Entry informationi

Entry nameiPNP_HELPJ
AccessioniPrimary (citable) accession number: Q9ZK11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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