Reviewed, UniProtKB/Swiss-Prot Q9ZJZ7 (AK_HELPJ)

Names and origin

Protein names

Recommended name:
    Aspartokinase
    EC=2.7.2.4
Alternative name(s):
    Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	jhp_1150

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family. Contains 2 ACT domains.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Domain	Repeat
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Aspartokinase		PRO_0000066678
Regions
	Domain	271 – 337	67	ACT 1
	Domain	344 – 400	57	ACT 2

Sequences

	Sequence		Length	Mass (Da)
	Q9ZJZ7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E43A0D62E890A8EF	FASTA	405	44,220
	10 20 30 40 50 60 MLIVQKYGGT SMGSIERIHN VAQRVLESVK LGHQVVVVVS AMSGETDRLL EFGKNFSHNP 70 80 90 100 110 120 NKREMDRIVS AGEWISSAAL SMALERYGHR AISLSGKEAG ILTSSHFQNA VIQSIDTQRI 130 140 150 160 170 180 TELLEKNYIV VIAGFQGADI QGETTTLGRG GSDLSAVALA GALKAHLCEI YTDVDGVYTT 190 200 210 220 230 240 DPRIEEKAQK IAQISYDEML ELASMGAKVL LNRSVELAKK LSVKLVTRNS FNHSEGTLIV 250 260 270 280 290 300 AEKDFKGERM ETPIVSGIAL DKNQARVSME GVEDRPGIAA EIFGALAEYR INVDMIVQTI 310 320 330 340 350 360 GRDGKTDLDF TIVKTQIEET KQALKPFLAQ MDSIDYDENI AKVSIVGVGM KSHSGVASIA 370 380 390 400 FKALAKDNIN IMMISTSEIK ISVLIDIKYA ELAVRTLHAV YQLDQ

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD06723.1.
PIR	H71843.
RefSeq	NP_223868.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	889810.
GenomeReviews	Gene locus jhp_1150 in contig AE001439_GR.
KEGG	hpj:jhp1150.
NMPDR	fig|85963.1.peg.1146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZJZ7.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP1150-MON.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kin_reg. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 2 hits. [Graphical view]
TIGRFAMs	TIGR00656. asp_kin_monofn. 1 hit. TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

AK_HELPJ

Accession

Primary (citable) accession number: Q9ZJZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)