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Q9ZJX4

- SYW_HELPJ

UniProt

Q9ZJX4 - SYW_HELPJ

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei198 – 1981ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-1210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:trpS
    Ordered Locus Names:jhp_1174
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Tryptophan--tRNA ligasePRO_0000136638Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi85963.jhp1174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZJX4.
    SMRiQ9ZJX4. Positions 4-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 209"HIGH" region
    Motifi195 – 1995"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiIDPKKHI.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZJX4-1 [UniParc]FASTAAdd to Basket

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    MQKKRVFSGI QPTGQIHLGN YLGAIKHWVE LQDEYENLFC IVNSHAITLP    50
    IEPIFLKSQT YELVKLLLAC GISPKQSGLF IQSEVDEHPA LAWLLDCQVS 100
    MGEMQRMTQF KDKSLKNPKS VNVGLFNYPI LMASDILLYQ SDLVPVGEDQ 150
    KQHLELTRNV AEKFNRDFGN CFKVPEPLIA KVGARVMGLD DPKVKMSKSH 200
    KGANHAIFLL DEPDVIVKKI KKAATDSMGV IAFDETREGV FNLLNIYMLL 250
    SDESPEKIEE RFRNKGYGDF KKELAEVVIQ SLKPIQERYQ EISDDEVKAV 300
    LNCGAEKARP LARATYQKAK ELMGLI 326
    Length:326
    Mass (Da):36,856
    Last modified:May 1, 1999 - v1
    Checksum:iB99F0EFC9E9FA491
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06748.1.
    PIRiE71841.
    RefSeqiNP_223892.1. NC_000921.1.
    WP_010882615.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06748; AAD06748; jhp_1174.
    GeneIDi889808.
    KEGGihpj:jhp1174.
    PATRICi20607188. VBIHelPyl98156_1275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06748.1 .
    PIRi E71841.
    RefSeqi NP_223892.1. NC_000921.1.
    WP_010882615.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZJX4.
    SMRi Q9ZJX4. Positions 4-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp1174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06748 ; AAD06748 ; jhp_1174 .
    GeneIDi 889808.
    KEGGi hpj:jhp1174.
    PATRICi 20607188. VBIHelPyl98156_1275.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi IDPKKHI.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-1210-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiSYW_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZJX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3