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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 2 (trpG), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-1292-MONOMER
UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:jhp_1200
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542811 – 452Tryptophan biosynthesis protein TrpCFAdd BLAST452

Proteomic databases

PRIDEiQ9ZJU8

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1200

Structurei

3D structure databases

ProteinModelPortaliQ9ZJU8
SMRiQ9ZJU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 253Indole-3-glycerol phosphate synthaseAdd BLAST253
Regioni254 – 448N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST195

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
COG0135 LUCA
KOiK13498
OMAiYDIIGIN
OrthoDBiPOG091H02GI

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00134_B IGPS_B, 1 hit
MF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZJU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVLENILK DKLLEVAVLK KNHALPINIA PSDRDFKKAL LEKKTSFILE
60 70 80 90 100
YKKASPSKGL IRKDFDLLEI TKTYEKFASC VSVLADSKYF LGSYENIKIV
110 120 130 140 150
SQHSTKPILC KDFIIDAFQI KLARVMGSNA VLLMLSVLDD KNYLELFNLA
160 170 180 190 200
KSLNMSVLTE VSNQQEIERL LKLQYDIIGI NNRDLHTLKT DIFHTLELRP
210 220 230 240 250
LLPKDAIIIS ESGIYSHAQI KALAPCVNGF LVGSSLMKEK DLKKACIKLI
260 270 280 290 300
LGENKVCGLT RIKDAKAVYK NHFIYGGLIF EKSSPRYIKP KEALKITKAV
310 320 330 340 350
KKLDFVGVFV KDKIKKIAKI AKKLDLKAVQ LYGYSQKEIA QLKKSLPKTC
360 370 380 390 400
AIWQVVSVAD SKDLAPKTKE ASLILYDTKG DKMGGNGVSF DWEILENAKT
410 420 430 440 450
PFMLAGGLNL DNIQKALKIK ALGLDFNSGL EISPGIKNKD KIKQLARILR

EY
Length:452
Mass (Da):50,678
Last modified:May 1, 1999 - v1
Checksum:i153AD3B136C632F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06779.1
PIRiD71836
RefSeqiWP_001141390.1, NZ_CP011330.1

Genome annotation databases

EnsemblBacteriaiAAD06779; AAD06779; jhp_1200
KEGGihpj:jhp_1200
PATRICifig|85963.30.peg.1372

Entry informationi

Entry nameiTRPC_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health