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Q9ZJU5 (TRPE_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:jhp_1203
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Anthranilate synthase component 1
PRO_0000154095

Sequences

Sequence LengthMass (Da)Tools
Q9ZJU5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F29392D3FFAD67FA

FASTA50056,587
        10         20         30         40         50         60 
MISLIEKAPY IPYPLALYEK LEQRHTLLFE SAEIESKAHT KSLLMAKACL KLVCNHNIVT 

        70         80         90        100        110        120 
ITSLTPNGGA FLQTLSAFFK TPIQDNALTL TYTKDKKIQD EFLKLFEPSP FDALRGLFKS 

       130        140        150        160        170        180 
VKTRPKHPFT LFSAGVFSFE MLNFFEDLPH LKANDNTAND FIFYVAQNLI IIDHKEKSAE 

       190        200        210        220        230        240 
ILGACFDERF KTEIAKELQD LKELVKNIKS DFIPKKAKQS IEVSVSCDDS EFEKKVLFLQ 

       250        260        270        280        290        300 
EEIKKGEIFQ AVLSRSFYME CLEGLSAYYH LKLSNPSPYM FYIKDSDFIL FGASPESALK 

       310        320        330        340        350        360 
YNALTNTAEI YPIAGTRLRG KDKQGNIDYD LDSKMEFDLQ HDYKERAEHI MLVDLARNDM 

       370        380        390        400        410        420 
ARVSKKRYCD KLLKVDKYSN VMHLVSRVVG ELKKGCDSLH AYRSFMNAGT LSGAPKISAI 

       430        440        450        460        470        480 
KLIYQLENQR RGSYGGSVGY LNSEGSMDSC ITIRSCFVKN NRAVIQAGAG IVLDSVPQNE 

       490        500 
ANETRAKVQA LIDAIRKTIS

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001439 Genomic DNA. Translation: AAD06782.1.
PIRG71836.
RefSeqNP_223921.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZJU5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZJU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID889828.
GenomeReviewsGene locus jhp_1203 in contig AE001439_GR.
KEGGhpj:jhp1203.
NMPDRfig|85963.1.peg.1199.
PATRIC20607246. VBIHelPyl98156_1304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0147.
HOGENOMHBG507440.
OMAVGYLNAL.
ProtClustDBPRK13564.

Enzyme and pathway databases

BioCycHPYL85963:JHP1203-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005257. Anth_synth_I_TrpE.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00565. TrpE_proteo. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_HELPJ
AccessionPrimary (citable) accession number: Q9ZJU5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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