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Q9ZJT0

- MAP1_HELPJ

UniProt

Q9ZJT0 - MAP1_HELPJ

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Protein
Methionine aminopeptidase
Gene
map, jhp_1219
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Substrate By similarity
Metal bindingi95 – 951Divalent metal cation 1 By similarity
Metal bindingi106 – 1061Divalent metal cation 1 By similarity
Metal bindingi106 – 1061Divalent metal cation 2; catalytic By similarity
Metal bindingi169 – 1691Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei176 – 1761Substrate By similarity
Metal bindingi206 – 2061Divalent metal cation 2; catalytic By similarity
Metal bindingi237 – 2371Divalent metal cation 1 By similarity
Metal bindingi237 – 2371Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1255-MONOMER.

Protein family/group databases

MEROPSiM24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase (EC:3.4.11.18)
Short name:
MAP
Short name:
MetAP
Alternative name(s):
Peptidase M
Gene namesi
Name:map
Ordered Locus Names:jhp_1219
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Methionine aminopeptidaseUniRule annotation
PRO_0000148942Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85963.jhp1219.

Structurei

3D structure databases

ProteinModelPortaliQ9ZJT0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
KOiK01265.
OMAiHICQTHA.
OrthoDBiEOG6MWNDS.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.
PROSITEiPS00680. MAP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZJT0-1 [UniParc]FASTAAdd to Basket

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MAISIKSPKE IKALRKAGEL TAQALALLER EVRPGVSLLE LDKMAEDFIK    50
SSHARPAFKG LYGFPNSVCM SLNEVVIHGI PTDYVLQEGD IIGLDLGVEV 100
DGYYGDSALT LPIGAISPQD EKLLACSKES LMHAISSIRV GMHFKELSQI 150
LEGAITERGF VPLKGFCGHG IGKKPHEEPE IPNYLEKGVK ANSGPKIKEG 200
MVFCLEPMVC QKQGEPKILA DKWSVVSVDG LNTSHHEHTI AIVGNKAVIL 250
TER 253
Length:253
Mass (Da):27,464
Last modified:May 1, 1999 - v1
Checksum:iD588885F32C34150
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06803.1.
PIRiC71833.
RefSeqiNP_223937.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06803; AAD06803; jhp_1219.
GeneIDi889835.
KEGGihpj:jhp1219.
PATRICi20607280. VBIHelPyl98156_1321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD06803.1 .
PIRi C71833.
RefSeqi NP_223937.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZJT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp1219.

Protein family/group databases

MEROPSi M24.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD06803 ; AAD06803 ; jhp_1219 .
GeneIDi 889835.
KEGGi hpj:jhp1219.
PATRICi 20607280. VBIHelPyl98156_1321.

Phylogenomic databases

eggNOGi COG0024.
KOi K01265.
OMAi HICQTHA.
OrthoDBi EOG6MWNDS.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-1255-MONOMER.

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
HAMAPi MF_01974. MetAP_1.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 1 hit.
TIGRFAMsi TIGR00500. met_pdase_I. 1 hit.
PROSITEi PS00680. MAP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiMAP1_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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