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Q9ZJL3 (LON_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lon protease
EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Ordered Locus Names:jhp_1293
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm.

Induction

By heat shock By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 831831Lon protease
PRO_0000076138

Regions

Domain9 – 197189Lon
Nucleotide binding367 – 3748ATP By similarity
Compositional bias708 – 7125Poly-Lys

Sites

Active site7371 By similarity
Active site7801 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZJL3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1B9249B3C49B1D5E

FASTA83193,946
        10         20         30         40         50         60 
MTEDFPKILP LLVEEDTFLY PFMIAPIFLQ NNASIKAVAY AKNNKSLVFI ACQKDKLNDN 

        70         80         90        100        110        120 
EAPYYDVGVI GSVMREANMP NGRVKLLFNG IAKGRILEPA KENEQGFLEA QISPIEYLEY 

       130        140        150        160        170        180 
DKENIQAIVE VLKEKVITLA NVSSLFPPDL IKALEDNDDP NRIADLIAAA LHLKKDQAYF 

       190        200        210        220        230        240 
LFANNNTEQR LLDLIDIVIE ETKTQKLQKE IKSKVHQKME QTNKEYFLKE QLKQIQKELG 

       250        260        270        280        290        300 
TDKQRDEDLN QYYQKLESIK PFLKEEAFKE IKKQIDRLSR THADSSDSAT LQNYVETMLD 

       310        320        330        340        350        360 
VPFGQYEKKA LDIKHVKEQL DNDHYSLKRP KERIVEYFAT MQLLEMRHKK KPEKKDKTKG 

       370        380        390        400        410        420 
TILCFYGPPG VGKTSLANSI AKAIERPLVR IALGGLEDVN ELRGHRRTYI GSMPGRIVQG 

       430        440        450        460        470        480 
LIEAKKMNPV MVLDEIDKVD RSVRGDPASA LLEILDPEQN IAFRDHYANF SIDLSQVIFI 

       490        500        510        520        530        540 
ATANNIDRIP APLRDRMEFI SVSSYTPSEK EEIAKNYLIP QELEKHALKP SEVDISHECL 

       550        560        570        580        590        600 
KLIIEKYTRE AGVRDLRRQI ATIMRKAALK YLEDNPHKKG RTKKSEDKDK KGGNEENEKR 

       610        620        630        640        650        660 
GESKDFCVSI TPDNLKEYLE RMVFEIDPID EENKIGIVNG LAWTPVGGDV LKIEAVKIRG 

       670        680        690        700        710        720 
KGELKLTGSL GDVMKESAII AFSVVKVLLD NETLKVPKIP SETDAENKKK KKVLKVYNAY 

       730        740        750        760        770        780 
DLHLHVPEGA TPKDGPSAGI AMASVMASIL CDRAIRSEVA MTGELTLSGE VLPIGGLKEK 

       790        800        810        820        830 
LIAAFKAGIK TALIPVKNYE RDLDEIPTEV RENLNIVAVK NIAEVLEKTL L

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References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001439 Genomic DNA. Translation: AAD06875.1.
PIRA71825.
RefSeqNP_224011.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZJL3.
SMRQ9ZJL3. Positions 634-830.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZJL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID890375.
GenomeReviewsGene locus jhp_1293 in contig AE001439_GR.
KEGGhpj:jhp1293.
NMPDRfig|85963.1.peg.1289.
PATRIC20607440. VBIHelPyl98156_1401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0466.
HOGENOMHBG566281.
OMAGTILCFY.
ProtClustDBCLSK872549.

Enzyme and pathway databases

BioCycHPYL85963:JHP1293-MONOMER.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00763. Lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_HELPJ
AccessionPrimary (citable) accession number: Q9ZJL3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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