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Q9ZJ81

- NADK_HELPJ

UniProt

Q9ZJ81 - NADK_HELPJ

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Protein
NAD kinase
Gene
nadK, jhp_1433
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptor By similarity
Binding sitei167 – 1671NAD By similarity
Binding sitei169 – 1691NAD By similarity
Binding sitei177 – 1771NAD; via carbonyl oxygen By similarity
Binding sitei236 – 2361NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 712NAD By similarity
Nucleotide bindingi139 – 1402NAD By similarity
Nucleotide bindingi180 – 1856NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:jhp_1433
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinaseUniRule annotation
PRO_0000120624Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1433.

Structurei

3D structure databases

ProteinModelPortaliQ9ZJ81.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZJ81-1 [UniParc]FASTAAdd to Basket

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MKDLNKTIGV FVRPTHHQNA LFKELEQAKE WVLTLLEDEG FESFMIDSLD    50
GAKDAQLIKK AYAFLCLGGD GTILGALRMT HAHNKPCFGV RIGNLGFLSA 100
VELNGLKDFL QDLKQNRIKL EEHLALEGRI GNTSFYAINE IVIAKKKALG 150
VLDIKACAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL 200
TPLCDFSLTQ RPLVLGAEFC LSFCAHEDAL VVIDGQATYD LKANQPLYIQ 250
KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP NKKR 284
Length:284
Mass (Da):31,447
Last modified:May 4, 2001 - v2
Checksum:iE7E4056AC802BA7C
GO

Sequence cautioni

The sequence AAD07009.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD07009.1. Different initiation.
PIRiA71807.
RefSeqiNP_224151.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD07009; AAD07009; jhp_1433.
GeneIDi889455.
KEGGihpj:jhp1433.
PATRICi20607760. VBIHelPyl98156_1558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD07009.1 . Different initiation.
PIRi A71807.
RefSeqi NP_224151.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZJ81.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85963.jhp1433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07009 ; AAD07009 ; jhp_1433 .
GeneIDi 889455.
KEGGi hpj:jhp1433.
PATRICi 20607760. VBIHelPyl98156_1558.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-1473-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiNADK_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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