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Q9ZJ81

- NADK_HELPJ

UniProt

Q9ZJ81 - NADK_HELPJ

Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (04 May 2001)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation
    Binding sitei169 – 1691NADUniRule annotation
    Binding sitei177 – 1771NAD; via carbonyl oxygenUniRule annotation
    Binding sitei236 – 2361NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 712NADUniRule annotation
    Nucleotide bindingi139 – 1402NADUniRule annotation
    Nucleotide bindingi180 – 1856NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-1473-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:jhp_1433
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284NAD kinasePRO_0000120624Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp1433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZJ81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZJ81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDLNKTIGV FVRPTHHQNA LFKELEQAKE WVLTLLEDEG FESFMIDSLD    50
    GAKDAQLIKK AYAFLCLGGD GTILGALRMT HAHNKPCFGV RIGNLGFLSA 100
    VELNGLKDFL QDLKQNRIKL EEHLALEGRI GNTSFYAINE IVIAKKKALG 150
    VLDIKACAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL 200
    TPLCDFSLTQ RPLVLGAEFC LSFCAHEDAL VVIDGQATYD LKANQPLYIQ 250
    KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP NKKR 284
    Length:284
    Mass (Da):31,447
    Last modified:May 4, 2001 - v2
    Checksum:iE7E4056AC802BA7C
    GO

    Sequence cautioni

    The sequence AAD07009.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD07009.1. Different initiation.
    PIRiA71807.
    RefSeqiNP_224151.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07009; AAD07009; jhp_1433.
    GeneIDi889455.
    KEGGihpj:jhp1433.
    PATRICi20607760. VBIHelPyl98156_1558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD07009.1 . Different initiation.
    PIRi A71807.
    RefSeqi NP_224151.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZJ81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp1433.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07009 ; AAD07009 ; jhp_1433 .
    GeneIDi 889455.
    KEGGi hpj:jhp1433.
    PATRICi 20607760. VBIHelPyl98156_1558.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-1473-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiNADK_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZJ81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3