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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei575ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-1559-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:jhp_1452
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520271 – 806Leucine--tRNA ligaseAdd BLAST806

Proteomic databases

PRIDEiQ9ZJ63

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1452

Structurei

3D structure databases

ProteinModelPortaliQ9ZJ63
SMRiQ9ZJ63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 48"HIGH" regionAdd BLAST11
Motifi572 – 576"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZJ63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFINIEKKW QEFWWKNKSF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR
60 70 80 90 100
NYTIGDALAR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN
110 120 130 140 150
IEAMQKEFEA LGFSFSKNRE FATSDPDYTK FEQQFFIDLW EKGLIYRKKA
160 170 180 190 200
MLNWCPNDKT VLANEQVIDG RCWRCDTEVI QKELYQYYLK ITNYAEELLK
210 220 230 240 250
DLETLENHWP SQVLTMQKNW IGKSSGLQFG FKIADECLKA CNNIQEIEVF
260 270 280 290 300
TTRADTIYGV TYIAIAPEHP LVEHAIKRVS QEDSKMIKAI LNTTQRERAL
310 320 330 340 350
EKKGAFLGIY AIHPLTKQKI PVWVANFALA NYGSGALMGV PACDERDFEF
360 370 380 390 400
ANLYHIPIKV ITQSPQNLPH TKEEILKNSG EWSDLSSSVA REKIIAYFEK
410 420 430 440 450
ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCKHCGIVPE TQLPVTLPED
460 470 480 490 500
IVIDGEGNPL EKHASWKFAQ CPKCHKDALR ETDTMDTFIQ SSWYFLRYTT
510 520 530 540 550
PKNQRENQAF DQNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY
560 570 580 590 600
LHLDEPFKQL ITQGMVLKDG AKMSKSKGNV VSPKEILKKY GADAVRLFIL
610 620 630 640 650
FAAPPAKELE WNDNALEGAH RFIKRLYDKA NAITPTTSKP EFKEVGLNEA
660 670 680 690 700
QKLARKKVYE ALKKSHEIFN KAESAYAFNT LIASCMEALN ALNAQSDEQI
710 720 730 740 750
LCEGYFVLLQ ILEPMIPHTA WELSERLFKR ENFKPIEVDE SALIEDFMTL
760 770 780 790 800
GLTINGKRRA ELKVNINASK EEIIILAKKE LEKYLENASV KKEIYVPNKL

VNFVTA
Length:806
Mass (Da):93,212
Last modified:May 1, 1999 - v1
Checksum:iCE1BF5967AF21466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD07021.1
PIRiG71805
RefSeqiWP_000345685.1, NZ_CP011330.1

Genome annotation databases

EnsemblBacteriaiAAD07021; AAD07021; jhp_1452
KEGGihpj:jhp_1452
PATRICifig|85963.30.peg.1091

Similar proteinsi

Entry informationi

Entry nameiSYL_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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