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Q9ZJ28

- PDXA_HELPJ

UniProt

Q9ZJ28 - PDXA_HELPJ

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Metal bindingi156 – 1561Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi195 – 1951Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi251 – 2511Divalent metal cation; shared with dimeric partnerUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Binding sitei277 – 2771SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-1530-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:jhp_1490
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3073074-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188810Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi85963.jhp1490.

Structurei

3D structure databases

ProteinModelPortaliQ9ZJ28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1995.
KOiK00097.
OMAiISIKLAM.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZJ28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKKIAISC GDIQGVGLEL ILKSHKEVSA LCEPLYLVHS ELLERANQLL
60 70 80 90 100
DNAYETKTLN AIAIDAPLPL LNSSTIGKVS TQSGAYSFES FKKACELADS
110 120 130 140 150
KEVDGICTLP INKLAWQQAQ IPFVGHTDFL KQRYKDHQII MMLGCSKLFV
160 170 180 190 200
GLFSDHVPLS AVSQLIQVKA LVKFLLAFQK STQAKIVQVC GFNPHAGEEG
210 220 230 240 250
LFGEEDEKIL KAIQESNQTL GFECFLGPLP ADSAFAPNKR KITPFYVSMS
260 270 280 290 300
HDVGLAPLKA LYFDESINVS LNAPILRAST DHGTAFDIAY QNKANHKSYL

NAIKYLA
Length:307
Mass (Da):33,706
Last modified:May 1, 1999 - v1
Checksum:i77C5FD2DD9A71A81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD07064.1.
PIRiD71801.
RefSeqiNP_224208.1. NC_000921.1.
WP_001075049.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD07064; AAD07064; jhp_1490.
GeneIDi889008.
KEGGihpj:jhp1490.
PATRICi20607880. VBIHelPyl98156_1618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD07064.1 .
PIRi D71801.
RefSeqi NP_224208.1. NC_000921.1.
WP_001075049.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZJ28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp1490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07064 ; AAD07064 ; jhp_1490 .
GeneIDi 889008.
KEGGi hpj:jhp1490.
PATRICi 20607880. VBIHelPyl98156_1618.

Phylogenomic databases

eggNOGi COG1995.
KOi K00097.
OMAi ISIKLAM.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci HPYL85963:GJB9-1530-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiPDXA_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJ28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3