Q9ZIX8 (OTCC_HAEGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:

arcB

Organism

Haemophilus gallinarum

Taxonomic identifier

728 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Avibacterium

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112929
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	273 – 276	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZIX8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C31F7619E0B68DCB	FASTA	334	37,444
	10 20 30 40 50 60 MLFNLKNRHL LSLVHHTPQE IQFLLQLAKE LKQAKYTGTE QPRLKGKNIA LIFEKTSTRT 70 80 90 100 110 120 RCSFEVAAYD QGANVTYIDP NSSQIGHKES MKDTARVLGR MYDAIEYRGF KQAVVNELAE 130 140 150 160 170 180 YAGVPVFNGL TDEFHPTQML ADVLTMMEHS DKPLSDIIYV YIGDARNNMG NSLLLIGAKL 190 200 210 220 230 240 GMDVRICAPK ALQPEAELVA MCQEFAQQTG ARITITEDVE LAVKGVDFVH TDVWVSMGEP 250 260 270 280 290 300 LESWGERINL LLPYQVTPAL MQRSGNPKVK FMHCLPAFHN CETEVGKKIA EKYPHLANGI 310 320 330 EVTEEVFESP MNIAFDQAEN RMHTIKAVMV ASLA

References

[1]	Wise A.G., Glisson J.R., Jackwood M.W. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: H-18.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007428 Genomic DNA. Translation: AAD01405.1.
3D structure databases
ProteinModelPortal	Q9ZIX8.
SMR	Q9ZIX8. Positions 3-334.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_HAEGA

Accession

Primary (citable) accession number: Q9ZIX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program