Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ZIG2 (KITH_RHOSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
OrganismRhodothermus sp. (strain ITI 518)
Taxonomic identifier71277 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeRhodothermus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175010

Regions

Nucleotide binding22 – 298ATP By similarity
Nucleotide binding94 – 974ATP By similarity

Sites

Active site951Proton acceptor Potential
Metal binding1511Zinc By similarity
Metal binding1541Zinc By similarity
Metal binding1831Zinc By similarity
Metal binding1861Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZIG2 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A086F049ED6BD786

FASTA21323,644
        10         20         30         40         50         60 
MPMEPLILRH GGSVGWIEVI CGSMFSGKTE ELIRRLRRAQ IARQRVEVFK PRMDRRYSET 

        70         80         90        100        110        120 
DVVSHDENAL RSTPVDSAEQ ILLLADSADV VGIDEAQFFD MTLVDVCQQL ANDGKRVIVA 

       130        140        150        160        170        180 
GLDQEYMGRP LEPMPQFMAV AEYVTKLHAI CAVCGAPANH SQRLTDEEGR VVLGAADRYE 

       190        200        210 
PRCRRCFQPP RPTSTSSLKA PAPAATAPRP ELP 

« Hide

References

[1]"Nucleotide sequence and deduced amino acid sequence of thymidine kinase gene (tdk) from Rhodothermus sp. ITI 518."
Blondal T., Thorbjarnardottir S.H., Kielezawa J., Eggertsson G.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF028720 Genomic DNA. Translation: AAC98909.1.
PIRT47123.

3D structure databases

ProteinModelPortalQ9ZIG2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_RHOSI
AccessionPrimary (citable) accession number: Q9ZIG2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families