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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 12911258Sequence analysisPRO_5004337656Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9ZHU6.
SMRiQ9ZHU6. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1018 – 1291274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPASVGGIAT
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWRIQAGRGF NEFPNKEYDL
110 120 130 140 150
YQALLSSKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSFKD SADRTTRVDF NAKNILIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSGAKSDKNE
360 370 380 390 400
SAKNDKQDSN TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT
410 420 430 440 450
NADGTIRVGG YTASLTTNAA HLNIGKGGVN LSNQASGRSL LVENLTGNIT
460 470 480 490 500
VDGALMVNNQ VGGYALAGSS ANFEFKAGVD TKNGTIAFNN NISLGRFVNL
510 520 530 540 550
KASAHTVNFK DIDTGNGGFN TLDFSGVTNK VNINKLITAS TNVAVKNFNI
560 570 580 590 600
NELLVKTNGI SVGEYTNFSE DIGNQSRINT VRLETGTRSI YSGGVKFKGG
610 620 630 640 650
EKLVINDFYY APWNYFDARN IKNVEITNKL AFGPQGSPWG TAKLMFNNLT
660 670 680 690 700
LGPNAVMDYS QFSNVTIQGN FINNQGTINY LVRGGNIETL NVGNAAVMSF
710 720 730 740 750
NNEIDSATGF YKPLIKINSA QDLIKNKEHV LLKAKIIGYE NASLGTNSIS
760 770 780 790 800
NAKLIEQFNE RLALYNNNNR MDTCVVRNTD DIKACGMAIG DQAMVNNPDN
810 820 830 840 850
YKYLIGKAWK NIGISKTANG SKISVRYLGN ATPAENGGNT TNLPTNTTNN
860 870 880 890 900
ARFARYALIK NAPFAQASAT PNLVAINKHD FGTIESVFEL ANRSEDIDTL
910 920 930 940 950
YAHSGAKGRD LLQTLLIDSH NAGYARTMID ATSANEITKQ LNTATDALNN
960 970 980 990 1000
IASLEHKTSG LQTLSLSNAM ILNSRLVNLS RRHTNNIDSF AKRLQALKDQ
1010 1020 1030 1040 1050
RFASLESAAE VLYQFAPKYE KPTNVWANAI GGASLNSCGN TSLYGTSAGV
1060 1070 1080 1090 1100
DAYLNEKVEA IVGGFGSYGY SSFNNQANSL NSGANNANFG VYSRIFANRH
1110 1120 1130 1140 1150
EFDFEAQGAL GSDQSSLNFK GALLRDLNQS YNYLAYGASA RASYGYDFAF
1160 1170 1180 1190 1200
FRNALVLKPS VGVSYNHLGS TNFESNSTNK TALKNGASSQ HLFNASANVE
1210 1220 1230 1240 1250
ARYYYGDTSY FYMNAGVLQE FANFGSSNAV SLNTFKVNTA RNPLNTHARV
1260 1270 1280 1290
MMGGELQLAK EVFLNLGFVY LHNLISNIGH FASNLGMRYS F
Length:1,291
Mass (Da):139,440
Last modified:May 1, 1999 - v1
Checksum:iFD05AA63664A7158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049633 Genomic DNA. Translation: AAD04271.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049633 Genomic DNA. Translation: AAD04271.1.

3D structure databases

ProteinModelPortaliQ9ZHU6.
SMRiQ9ZHU6. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
    Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
    J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F56Imported.

Entry informationi

Entry nameiQ9ZHU6_HELPX
AccessioniPrimary (citable) accession number: Q9ZHU6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.