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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9ZHU3.
SMRiQ9ZHU3. Positions 396-851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1023 – 1296274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQTHRKI NRPLVSLALV GLLVSITPQK SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWRIQAGRGF NEFPNKEYDL
110 120 130 140 150
YKSLLSSKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
YTGGDLDVNM QKATLRLGQF NGNSFTSFKD GADRTTRVDF NAKNISIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VAGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSGAKNDKNE
360 370 380 390 400
SAKNDKQESS QNNSNTQVIN PPNSGQKTEI QPTQVIDGPF AGAKDTVVNI
410 420 430 440 450
NRINTNADGT IRVGGYTASL TTNAAHLNIG KGGVNLSNQA SGRSLLVENL
460 470 480 490 500
TGNITVDGAL MVNNQVGGYA LAGSSANFEF KAGVDTKNGT IAFNNNISLG
510 520 530 540 550
RFVNLKASAH TVNFKDIDTG NGGFNTLHFS GVTNKVNINK LITASTNVAI
560 570 580 590 600
KNFNINELLV KTNGISVGEY TNFSEDIGNQ SRINTVRLET GTRSIYSGGV
610 620 630 640 650
KFKGGEKLVI NDFYYAPWNY FDARNIKNVE ITNKLAFGPQ GSPWGTSKLM
660 670 680 690 700
FNNLTLGPNA VMDYSQFSNV TIQGNFINNQ GTINYLVRGG NIETLSVGNA
710 720 730 740 750
AVMSFNNDID SATGFYKPLI KINSAQDLIK NKEHVLLKAK IIGYENASLG
760 770 780 790 800
TNSISNANLI EQFNERLALY NNNNRMDTCV VRNTDDIKAC GMAIGDQAMV
810 820 830 840 850
NNPDNYKYLI GKAWKNIGIS KTANGSKISV RYLGNATPAE NGGNTTNLPT
860 870 880 890 900
NATNNARFAS YALIKNAPFA QTNATPNLVA INKHDFGTIE SVFELANRSK
910 920 930 940 950
DIDTLYAHSG AQGRDLLQTL LIDSHDAGYA RTMIDATSAN EITKQLNTAT
960 970 980 990 1000
DALNNIASLE HKTSGLQTLS LSNAMILNSR LVNLSRRHTN NIDSFARRLQ
1010 1020 1030 1040 1050
ALKDQRFASL ESAAEVLYQF APKYEKPTNV WANAIGGASL NSGGNTSLYG
1060 1070 1080 1090 1100
TSAGVDAYLN EKVEAIVGGF GSYGYSSFNN QANSLNSGAN NANFGVYSRI
1110 1120 1130 1140 1150
FANRHEFDFE AQGAVGSDQS SLNFKSALLR DLNQSYNYLA YGAATRASYG
1160 1170 1180 1190 1200
YDFAFFRNAL VLKPSVGVSY NHLGSTNFES NSTNKTALKN GASSQHLFNA
1210 1220 1230 1240 1250
SANVEARYYY GDTSYFYMNA GVLQEFANFG SSNAVSLNTF KVNAARNPLN
1260 1270 1280 1290
THARVMMGGE LKLAKEVFLN LGFVYLHNLI SNIGHFASNL GMRYSF
Length:1,296
Mass (Da):139,964
Last modified:May 1, 1999 - v1
Checksum:iA47D7FC471925596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049641 Genomic DNA. Translation: AAD04276.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049641 Genomic DNA. Translation: AAD04276.1.

3D structure databases

ProteinModelPortaliQ9ZHU3.
SMRiQ9ZHU3. Positions 396-851.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori."
    Ito Y., Azuma T., Ito S., Suto H., Miyaji H., Yamazaki Y., Kohli Y., Kuriyama M.
    J. Infect. Dis. 178:1391-1398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F33Imported.

Entry informationi

Entry nameiQ9ZHU3_HELPX
AccessioniPrimary (citable) accession number: Q9ZHU3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.