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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9ZHU0.
SMRiQ9ZHU0. Positions 400-855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1027 – 1300274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQERKKM ELQQTHRKIN RPLVSLALVG LLVSITPQKS HAAFFTTVII
60 70 80 90 100
PAIVGGIATG AAVGTVSGLL GWGLKQAEEA NKTPDKPDKV WRIQAGRGFN
110 120 130 140 150
EFPNKEYDLY KSLLSSKIDG GWDWGNAARH YWVKGGQWNK LEVDMKDAVG
160 170 180 190 200
TYKLSGLINY TGGDLDVNMQ KATLRLGQFN GNSFTSFKDS ADRTTRVDFN
210 220 230 240 250
AKNILIDNFL EINNRVGSGA GRKASSTVLT LQASEGITSG KNAEISLYDG
260 270 280 290 300
ATLNLASNSV KLMGNVWMGR LQYVGAYLAP SYSTINTSKV TGEVNFNHLT
310 320 330 340 350
VGDRNAAQAG IIASKKTYIG TLDLWQSAGL NIIAPPEGGY KDKPNNTNSQ
360 370 380 390 400
SGAKNDKNES AKNDKQDSNT QVINPPNSGQ KTEIQPTQVI DGPFAGAKDT
410 420 430 440 450
VVNINRINTN ADGTIKVGGY TASLTTNAAN LNIGKGGVNL SNQASGRSLL
460 470 480 490 500
VENLTGNITV DGALMVNNQV GGYALAGSSA NFEFKAGVDT KNGTIAFNNN
510 520 530 540 550
ISLGRFVNLK ASAHTVNFKD IDTGNGGFNT LDFSSVTNKV NINKLITAST
560 570 580 590 600
NVAIKNFNIN ELLVKTNGIS VGEYTNFSED IGSQSRINTV RLETGTRSIY
610 620 630 640 650
SGGVKFKGGE KLVINDFYYA PWNYFDARNI KNVEITNKLA FGPQGSPWGT
660 670 680 690 700
AKLMFNNLTL GPNAVMDYSQ FSNVTIQGNF INNQGTINYL VRGGNIETLS
710 720 730 740 750
VGNAAVMSFN NDIDSATGFY KPLIKINSAQ DLIKNKEHVL LKAKIIGYEN
760 770 780 790 800
ASLGTNSISN ANLIEQFNER LALYNNNNRM DTCVVRNTDD IKACGMAIGD
810 820 830 840 850
QAMVNNPDNY KYLIGKAWKN IGISKTANGS KISVRYLGNA TPAENGGNTT
860 870 880 890 900
NLPTNATNNA RFASYALIKN APFAQTNATP NLVAINKHDF GTIESVFELA
910 920 930 940 950
NRSKDIDTLY AHSGAQGRDL LQTLLIDSHD AGYARTMIDA TSTNEITKQL
960 970 980 990 1000
NEANSALNNI ASLDHKTSGL QTLSLSNAMI LNSRLVNLSR RHTNNIDSFA
1010 1020 1030 1040 1050
KRLQALKDQK FASLESAAEV LYQFAPKYEK PTNVWANAIG GASLNSGGNT
1060 1070 1080 1090 1100
SLYGTSAGVD AYLNGEVEAI VGGFGSYGYS SFSNQANSLN SGANNANFGV
1110 1120 1130 1140 1150
YSRIFANQHE FDFEAQGAVG SDQSSLNFKG ALLRDLNQSY NLLAYGASAR
1160 1170 1180 1190 1200
ASYGYDFAFF RNALVLKPSV GVNYNHLGST NFESNSTHKA ALKNGASSQH
1210 1220 1230 1240 1250
LFNASANVEA RYYYGDTSYF YMNAGVLQEF TNFGSSNAVS LNTFKVNTAR
1260 1270 1280 1290 1300
NPLNTHARVM MGGELKLAKE VFLNLGFIYL HNLISNIGHF ASNLGMRYSF
Length:1,300
Mass (Da):140,395
Last modified:May 1, 1999 - v1
Checksum:iA6BB91ECD980EA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049644 Genomic DNA. Translation: AAD04280.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049644 Genomic DNA. Translation: AAD04280.1.

3D structure databases

ProteinModelPortaliQ9ZHU0.
SMRiQ9ZHU0. Positions 400-855.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ZHU0_HELPX
AccessioniPrimary (citable) accession number: Q9ZHU0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.