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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9ZHT4.
SMRiQ9ZHT4. Positions 399-854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1025 – 1298274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQTHRKI NRPLVSLALV GLLVSITPQK SHAAFFTTVI IPAIVGGIAS
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWRIQAGRGF NEFPNKEYDL
110 120 130 140 150
YKSLLSSKID GGWDWGNAAG HYWVKGGQWN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSFKD SADRTTRVDF NAKNISIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VVGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI STLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSSAKNDKQE
360 370 380 390 400
SAKNDKQESV KNDKQDSNTQ VINPPNSGQK TEIQPTQVID GPFAGAKDTV
410 420 430 440 450
VNINRINTNA DGTIKVGGYT ASLTTNAANL NIGKAVNLSN QASGRSLLVE
460 470 480 490 500
NLTGNITVDG ALMVNNQVGG YALAGSSANF EFKAGVDTKN GTIAFNNNIS
510 520 530 540 550
LGRFVNLKAS AHTVNFKDID TGNGGFNTLD FSGVTNKVNI NKLITASTNV
560 570 580 590 600
AIKNFNINEL LVKTNGISVG EYTNFSEDIG NQSRINTVRL ETGTRSIYSG
610 620 630 640 650
GVKFKGGEKL VINDFYYAPW NYFDARNIKN VEITNKLAFG PQGSPWGTAK
660 670 680 690 700
LMFNNLTLGP NAVMDYSQFS NVTIQGNFVN NQGTINYLVR GGNIETLNVG
710 720 730 740 750
NAAVMSFNND IDSTTGFYKP LIKINSAQDL IKNKEHVLLK AKIIGYENAS
760 770 780 790 800
LGTNSISNAN LIEQFNERLA LYNNNNRMDT CVVRNTDDIK ACGMAIGDQA
810 820 830 840 850
MVNNPDNYKY LIGKAWKNIG ISKTANGSKI SVRYLGNSTP TDNGGNTTNL
860 870 880 890 900
PTNTTNNARF ARYALIKNAP FAQTSATPNL VAINKHDFGT IESVFELANR
910 920 930 940 950
SKDIDTLYAN SGVQGRDLLQ TLLIDSHDAG YARTMIDATS ANEITKQLNT
960 970 980 990 1000
ATDALNNIAS LEHKTSGLQT LSLSNAMILN SRLVNLSRRH TNNIDSFAKR
1010 1020 1030 1040 1050
LQALKGQRFA SLESAAEVLY QFAPKYEKPT NVWANAIGGA SLNSGGNTSL
1060 1070 1080 1090 1100
YGTSAGVDAY LNEKVEAIVG GFGSYGYSSF SNQANSLNSG ANNANFGVYS
1110 1120 1130 1140 1150
RIFANQHEFD FEAQGAVGSD QSSLNFKGAL LRDLNQSYNY LAYGTSARAS
1160 1170 1180 1190 1200
YGYDFAFFRN ALVLKPSVGV NYNHLGSTNF ESNSTHKAAL KNGASSQHLF
1210 1220 1230 1240 1250
NASANVEARY YYGDTSYFYM NAGVLQEFAN FGSSNAVSLN TFKVNAARNP
1260 1270 1280 1290
LNTHARVMMG GELKLAKEVF LNLGFIYLHN LISNIGHFAS NLGMRYSF
Length:1,298
Mass (Da):140,251
Last modified:May 1, 1999 - v1
Checksum:iA2F3B9003256F7DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049650 Genomic DNA. Translation: AAD04286.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049650 Genomic DNA. Translation: AAD04286.1.

3D structure databases

ProteinModelPortaliQ9ZHT4.
SMRiQ9ZHT4. Positions 399-854.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ZHT4_HELPX
AccessioniPrimary (citable) accession number: Q9ZHT4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: December 9, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.