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Q9ZHG9

- Q9ZHG9_SYNY4

UniProt

Q9ZHG9 - Q9ZHG9_SYNY4

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Protein
Submitted name: L-cysteine/cystine lyase C-DES
Gene
c-des
Organism
Synechocystis sp. (strain PCC 6714) (Aphanocapsa sp. (strain PCC 6714))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Proton donor/acceptorImported
Sitei114 – 1141Important for catalytic activityImported
Sitei197 – 1971Important for catalytic activityImported
Sitei199 – 1991Important for catalytic activityImported
Sitei200 – 2001Important for catalytic activityImported
Sitei223 – 2231Important for catalytic activityImported
Metal bindingi316 – 3161Potassium; via carbonyl oxygenImported
Metal bindingi317 – 3171Potassium; via carbonyl oxygenImported
Metal bindingi319 – 3191Potassium; via carbonyl oxygenImported
Metal bindingi322 – 3221Potassium; via carbonyl oxygenImported
Binding sitei360 – 3601SubstrateImported

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Ligandi

Metal-bindingImported, PotassiumImported, Pyridoxal phosphateSAAS annotations

Enzyme and pathway databases

SABIO-RKQ9ZHG9.

Names & Taxonomyi

Protein namesi
Submitted name:
L-cysteine/cystine lyase C-DESImported
Gene namesi
Name:c-desImported
OrganismiSynechocystis sp. (strain PCC 6714) (Aphanocapsa sp. (strain PCC 6714))Imported
Taxonomic identifieri1147 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei223 – 2231N6-(pyridoxal phosphate)lysineImported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ELQX-ray1.80A/B4-393[»]
1ELUX-ray1.55A/B4-393[»]
1N2TX-ray2.00A/B9-393[»]
1N31X-ray2.20A/B9-393[»]
ProteinModelPortaliQ9ZHG9.
SMRiQ9ZHG9. Positions 13-393.

Miscellaneous databases

EvolutionaryTraceiQ9ZHG9.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHG9-1 [UniParc]FASTAAdd to Basket

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MADPVNLIPD RHQFPGLANK TYFNFGGQGI LPTVALEAIT AMYGYLQENG    50
PFSIAANQHI QQLIAQLRQA LAETFNVDPN TITITDNVTT GCDIVLWGLD 100
WHQGDEILLT DCEHPGIIAI VQAIAARFGI TYRFFPVAAT LNQGDAAAVL 150
ANHLGPKTRL VILSHLLWNT GQVLPLAEIM AVCRRHQGNY PVRVLVDGAQ 200
SAGSLPLDFS RLEVDYYAFT GHKWFAGPAG VGGLYIHGDC LGEINPTYVG 250
WRSITYGAKG EPTGWAEGGK RFEVATSAYP QYAGLLAALQ LHQRQGTAEE 300
RYQAICQRSE FLWRGLNQLP HVHCLATSAP QAGLVSFTVD SPLGHRAIVQ 350
KLEEQRIYLR TIADPDCIRA CCHYITDEEE INHLLARLAD FGP 393
Length:393
Mass (Da):43,154
Last modified:May 1, 1999 - v1
Checksum:i4AC0ADA899A3264C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061964 Genomic DNA. Translation: AAD02935.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061964 Genomic DNA. Translation: AAD02935.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ELQ X-ray 1.80 A/B 4-393 [» ]
1ELU X-ray 1.55 A/B 4-393 [» ]
1N2T X-ray 2.00 A/B 9-393 [» ]
1N31 X-ray 2.20 A/B 9-393 [» ]
ProteinModelPortali Q9ZHG9.
SMRi Q9ZHG9. Positions 13-393.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK Q9ZHG9.

Miscellaneous databases

EvolutionaryTracei Q9ZHG9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel L-cysteine/cystine C-S-lyase directing [2Fe-2S] cluster formation of Synechocystis ferredoxin."
    Leibrecht I., Kessler D.
    J. Biol. Chem. 272:10442-10447(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PCC 6714Imported.
  2. "Evidence for cysteine persulfide as reaction product of L-Cyst(e)ine C-S-lyase (C-DES) from Synechocystis. Analyses using cystine analogues and recombinant C-DES."
    Lang T., Kessler D.
    J. Biol. Chem. 274:189-195(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PCC 6714Imported.
  3. "Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis."
    Clausen T., Kaiser J.T., Steegborn C., Huber R., Kessler D.
    Proc. Natl. Acad. Sci. U.S.A. 97:3856-3861(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 4-393 IN COMPLEX WITH POTASSIUM, ACTIVE SITE, AND PYRIDOXAL PHOSPHATE AT LYS-223.
  4. "Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state."
    Kaiser J.T., Bruno S., Clausen T., Huber R., Schiaretti F., Mozzarelli A., Kessler D.
    J. Biol. Chem. 278:357-365(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 9-393 IN COMPLEX WITH POTASSIUM, ACTIVE SITE.

Entry informationi

Entry nameiQ9ZHG9_SYNY4
AccessioniPrimary (citable) accession number: Q9ZHG9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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