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Q9ZHE7

- HIS1_BUCAP

UniProt

Q9ZHE7 - HIS1_BUCAP

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.By similarity

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Feedback inhibited by histidine.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-101-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferase (EC:2.4.2.17)
    Short name:
    ATP-PRT
    Short name:
    ATP-PRTase
    Gene namesi
    Name:hisG
    Ordered Locus Names:BUsg_092
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299ATP phosphoribosyltransferasePRO_0000151834Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZHE7.

    Interactioni

    Subunit structurei

    Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg092.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZHE7.
    SMRiQ9ZHE7. Positions 6-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0040.
    KOiK00765.
    OMAiTRMQGVI.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZHE7-1 [UniParc]FASTAAdd to Basket

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    MFNTNRVRIA MQKTGRLSSE SIKLLTCCGI KINLKQQKLI AFAENMPIDV    50
    MLVRDDDIPG LVMDGVVDLG IVGENVLQEE LLHRISQNLE NSYITLRRLD 100
    FGICRLSLAI PINTPYVDIT SLKNFRIATS YPHLLKKYLD SKNIVFKSCM 150
    LNGSVEVAPR AGLADAICDL VSTGATLEAN GLREVQVVFR SHACLICKTG 200
    NINFAKKEVI NKLMTRIKGV IKARESKYIM LHAPVNKLEE VISLLHGAEK 250
    PTILKLAGDD HRVAMHMVSS ETLFWETMEK LKSLGASSIL VLPIEKMME 299
    Length:299
    Mass (Da):33,349
    Last modified:August 30, 2002 - v2
    Checksum:i8E0858F490DFF1C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti143 – 1453NIV → TL(PubMed:9767718)Curated
    Sequence conflicti147 – 1482KS → QV(PubMed:9767718)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97354.1.
    AE013218 Genomic DNA. Translation: AAM67662.1.
    RefSeqiNP_660451.1. NC_004061.1.
    WP_011053628.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67662; AAM67662; BUsg_092.
    GeneIDi1005909.
    KEGGibas:BUsg092.
    PATRICi21246961. VBIBucAph100086_0095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97354.1 .
    AE013218 Genomic DNA. Translation: AAM67662.1 .
    RefSeqi NP_660451.1. NC_004061.1.
    WP_011053628.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q9ZHE7.
    SMRi Q9ZHE7. Positions 6-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg092.

    Proteomic databases

    PRIDEi Q9ZHE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67662 ; AAM67662 ; BUsg_092 .
    GeneIDi 1005909.
    KEGGi bas:BUsg092.
    PATRICi 21246961. VBIBucAph100086_0095.

    Phylogenomic databases

    eggNOGi COG0040.
    KOi K00765.
    OMAi TRMQGVI.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci BAPH198804:GHMG-101-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
      Clark M.A., Baumann L., Baumann P.
      Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiHIS1_BUCAP
    AccessioniPrimary (citable) accession number: Q9ZHE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3