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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131NADBy similarity1
Binding sitei189NADBy similarity1
Binding sitei212NADBy similarity1
Binding sitei238SubstrateBy similarity1
Metal bindingi260ZincBy similarity1
Binding sitei260SubstrateBy similarity1
Metal bindingi263ZincBy similarity1
Binding sitei263SubstrateBy similarity1
Active sitei327Proton acceptorBy similarity1
Active sitei328Proton acceptorBy similarity1
Binding sitei328SubstrateBy similarity1
Metal bindingi361ZincBy similarity1
Binding sitei361SubstrateBy similarity1
Binding sitei415SubstrateBy similarity1
Metal bindingi420ZincBy similarity1
Binding sitei420SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-103-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BUsg_093
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357461 – 435Histidinol dehydrogenaseAdd BLAST435

Proteomic databases

PRIDEiQ9ZHE6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg093

Structurei

3D structure databases

ProteinModelPortaliQ9ZHE6
SMRiQ9ZHE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYFNTIVNW NMLNSNEQKN ILLRPVIKNN NSIKKKVKKI IENIQVLGEK
60 70 80 90 100
ALREYTILFE KCHINKFEVS KEKMLSSSLY VNQSLKDAIS TAKKNITSFH
110 120 130 140 150
TAQILSPIDI ETQVGVRCQQ IYLPLNSVGI YIPSGIAPLF STVLMLAIPA
160 170 180 190 200
KIAGCKQIIL CSPPPIDNTI LYAANICGVD KIFQMGGAQA IAALAFGTKN
210 220 230 240 250
IPKVDKIFGP GNAYVTEAKL QVSSIFNGPQ IDMLAGPSEL LIIADEASNA
260 270 280 290 300
DFIAADLLSQ AEHSISSQVI LLTPSLQLAK KVIISINNQL KNLSKSDDIS
310 320 330 340 350
TALDNSVIIL TKDLFECIKI SNIYAPEHLI IQTKEPRLIL KEILNASSIF
360 370 380 390 400
LGPWSPESAG DYASGTNHVL PTYGKSVSSS ALGLCDFKKR VLIQELTSQG
410 420 430
FINLSNTLKI LSEAEKLEAH KNAVKIRVDF LKEKI
Length:435
Mass (Da):47,738
Last modified:May 1, 1999 - v1
Checksum:iCD25387C2B62BDE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA Translation: AAC97355.1
AE013218 Genomic DNA Translation: AAM67663.1
RefSeqiWP_011053629.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67663; AAM67663; BUsg_093
KEGGibas:BUsg_093

Similar proteinsi

Entry informationi

Entry nameiHISX_BUCAP
AccessioniPrimary (citable) accession number: Q9ZHE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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