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Q9ZHE6

- HISX_BUCAP

UniProt

Q9ZHE6 - HISX_BUCAP

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NADBy similarity
Binding sitei189 – 1891NADBy similarity
Binding sitei212 – 2121NADBy similarity
Binding sitei238 – 2381SubstrateBy similarity
Metal bindingi260 – 2601ZincBy similarity
Binding sitei260 – 2601SubstrateBy similarity
Metal bindingi263 – 2631ZincBy similarity
Binding sitei263 – 2631SubstrateBy similarity
Active sitei327 – 3271Proton acceptorBy similarity
Active sitei328 – 3281Proton acceptorBy similarity
Binding sitei328 – 3281SubstrateBy similarity
Metal bindingi361 – 3611ZincBy similarity
Binding sitei361 – 3611SubstrateBy similarity
Binding sitei415 – 4151SubstrateBy similarity
Metal bindingi420 – 4201ZincBy similarity
Binding sitei420 – 4201SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-102-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BUsg_093
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Histidinol dehydrogenasePRO_0000135746Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg093.

Structurei

3D structure databases

ProteinModelPortaliQ9ZHE6.
SMRiQ9ZHE6. Positions 5-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYFNTIVNW NMLNSNEQKN ILLRPVIKNN NSIKKKVKKI IENIQVLGEK
60 70 80 90 100
ALREYTILFE KCHINKFEVS KEKMLSSSLY VNQSLKDAIS TAKKNITSFH
110 120 130 140 150
TAQILSPIDI ETQVGVRCQQ IYLPLNSVGI YIPSGIAPLF STVLMLAIPA
160 170 180 190 200
KIAGCKQIIL CSPPPIDNTI LYAANICGVD KIFQMGGAQA IAALAFGTKN
210 220 230 240 250
IPKVDKIFGP GNAYVTEAKL QVSSIFNGPQ IDMLAGPSEL LIIADEASNA
260 270 280 290 300
DFIAADLLSQ AEHSISSQVI LLTPSLQLAK KVIISINNQL KNLSKSDDIS
310 320 330 340 350
TALDNSVIIL TKDLFECIKI SNIYAPEHLI IQTKEPRLIL KEILNASSIF
360 370 380 390 400
LGPWSPESAG DYASGTNHVL PTYGKSVSSS ALGLCDFKKR VLIQELTSQG
410 420 430
FINLSNTLKI LSEAEKLEAH KNAVKIRVDF LKEKI
Length:435
Mass (Da):47,738
Last modified:May 1, 1999 - v1
Checksum:iCD25387C2B62BDE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA. Translation: AAC97355.1.
AE013218 Genomic DNA. Translation: AAM67663.1.
RefSeqiNP_660452.1. NC_004061.1.
WP_011053629.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67663; AAM67663; BUsg_093.
GeneIDi1005910.
KEGGibas:BUsg093.
PATRICi21246963. VBIBucAph100086_0096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA. Translation: AAC97355.1 .
AE013218 Genomic DNA. Translation: AAM67663.1 .
RefSeqi NP_660452.1. NC_004061.1.
WP_011053629.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q9ZHE6.
SMRi Q9ZHE6. Positions 5-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67663 ; AAM67663 ; BUsg_093 .
GeneIDi 1005910.
KEGGi bas:BUsg093.
PATRICi 21246963. VBIBucAph100086_0096.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BAPH198804:GHMG-102-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
    Clark M.A., Baumann L., Baumann P.
    Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiHISX_BUCAP
AccessioniPrimary (citable) accession number: Q9ZHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3