Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NADBy similarity
Binding sitei189 – 1891NADBy similarity
Binding sitei212 – 2121NADBy similarity
Binding sitei238 – 2381SubstrateBy similarity
Metal bindingi260 – 2601ZincBy similarity
Binding sitei260 – 2601SubstrateBy similarity
Metal bindingi263 – 2631ZincBy similarity
Binding sitei263 – 2631SubstrateBy similarity
Active sitei327 – 3271Proton acceptorBy similarity
Active sitei328 – 3281Proton acceptorBy similarity
Binding sitei328 – 3281SubstrateBy similarity
Metal bindingi361 – 3611ZincBy similarity
Binding sitei361 – 3611SubstrateBy similarity
Binding sitei415 – 4151SubstrateBy similarity
Metal bindingi420 – 4201ZincBy similarity
Binding sitei420 – 4201SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-102-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BUsg_093
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Histidinol dehydrogenasePRO_0000135746Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg093.

Structurei

3D structure databases

ProteinModelPortaliQ9ZHE6.
SMRiQ9ZHE6. Positions 5-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiIETFHNA.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYFNTIVNW NMLNSNEQKN ILLRPVIKNN NSIKKKVKKI IENIQVLGEK
60 70 80 90 100
ALREYTILFE KCHINKFEVS KEKMLSSSLY VNQSLKDAIS TAKKNITSFH
110 120 130 140 150
TAQILSPIDI ETQVGVRCQQ IYLPLNSVGI YIPSGIAPLF STVLMLAIPA
160 170 180 190 200
KIAGCKQIIL CSPPPIDNTI LYAANICGVD KIFQMGGAQA IAALAFGTKN
210 220 230 240 250
IPKVDKIFGP GNAYVTEAKL QVSSIFNGPQ IDMLAGPSEL LIIADEASNA
260 270 280 290 300
DFIAADLLSQ AEHSISSQVI LLTPSLQLAK KVIISINNQL KNLSKSDDIS
310 320 330 340 350
TALDNSVIIL TKDLFECIKI SNIYAPEHLI IQTKEPRLIL KEILNASSIF
360 370 380 390 400
LGPWSPESAG DYASGTNHVL PTYGKSVSSS ALGLCDFKKR VLIQELTSQG
410 420 430
FINLSNTLKI LSEAEKLEAH KNAVKIRVDF LKEKI
Length:435
Mass (Da):47,738
Last modified:May 1, 1999 - v1
Checksum:iCD25387C2B62BDE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA. Translation: AAC97355.1.
AE013218 Genomic DNA. Translation: AAM67663.1.
RefSeqiNP_660452.1. NC_004061.1.
WP_011053629.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67663; AAM67663; BUsg_093.
KEGGibas:BUsg093.
PATRICi21246963. VBIBucAph100086_0096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA. Translation: AAC97355.1.
AE013218 Genomic DNA. Translation: AAM67663.1.
RefSeqiNP_660452.1. NC_004061.1.
WP_011053629.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ9ZHE6.
SMRiQ9ZHE6. Positions 5-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67663; AAM67663; BUsg_093.
KEGGibas:BUsg093.
PATRICi21246963. VBIBucAph100086_0096.

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiIETFHNA.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciBAPH198804:GHMG-102-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
    Clark M.A., Baumann L., Baumann P.
    Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiHISX_BUCAP
AccessioniPrimary (citable) accession number: Q9ZHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.