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Q9ZHE5 (HIS8_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase

EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:BUsg_094
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01023

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01023

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
PRO_0000153333

Amino acid modifications

Modified residue2141N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZHE5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C919301FE84D6DC8

FASTA35540,474
        10         20         30         40         50         60 
MTANINKLAR KNIQKLNPYQ SARRIGGKGD TWLNANESPI SVPFKGKVKV FNRYPECQPN 

        70         80         90        100        110        120 
NLLSSYANYV GLLNNQILVT RGADEGIELL IKAFCEPGKD AIIYCPPTYD MYAINAKIAN 

       130        140        150        160        170        180 
VEIKEIPTFK NTWKIDLLNI RSNLNKVKLI YICNPNNPTG NIVSQEDLKS LLKVTLGQSL 

       190        200        210        220        230        240 
VIIDEAYIEF SPKNSMVNYL KTFPNLIILR TLSKAFALAG IRCGFTLAQK EVIDILHKVI 

       250        260        270        280        290        300 
SPYPISTLIA DIAVQSLEKK AIDDMKNRVL KLNMNRIWLI DELKKISCVK KVFDSHANYI 

       310        320        330        340        350 
LVEFYMFKKI FQSLWQKGII LRNQNHKNNL KNCLRISIGS KSECMRLVQE LKNFI 

« Hide

References

« Hide 'large scale' references
[1]"Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
Clark M.A., Baumann L., Baumann P.
Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067228 Genomic DNA. Translation: AAC97356.1.
AE013218 Genomic DNA. Translation: AAM67664.1.
RefSeqNP_660453.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ9ZHE5.
SMRQ9ZHE5. Positions 2-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg094.

Proteomic databases

PRIDEQ9ZHE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67664; AAM67664; BUsg_094.
GeneID1005911.
KEGGbas:BUsg094.
PATRIC21246965. VBIBucAph100086_0097.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
KOK00817.
OMAESNYLLV.
OrthoDBEOG651SWW.
ProtClustDBPRK01688.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-103-MONOMER.
UniPathwayUPA00031; UER00012.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01023. HisC_aminotrans_2.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01141. hisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_BUCAP
AccessionPrimary (citable) accession number: Q9ZHE5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names