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Q9ZHE5

- HIS8_BUCAP

UniProt

Q9ZHE5 - HIS8_BUCAP

Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. histidinol-phosphate transaminase activity Source: UniProtKB-HAMAP
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-103-MONOMER.
    UniPathwayiUPA00031; UER00012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol-phosphate aminotransferase (EC:2.6.1.9)
    Alternative name(s):
    Imidazole acetol-phosphate transaminase
    Gene namesi
    Name:hisC
    Ordered Locus Names:BUsg_094
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Histidinol-phosphate aminotransferasePRO_0000153333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei214 – 2141N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ9ZHE5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZHE5.
    SMRiQ9ZHE5. Positions 2-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0079.
    KOiK00817.
    OMAiRYECERV.
    OrthoDBiEOG651SWW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01023. HisC_aminotrans_2.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01141. hisC. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZHE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTANINKLAR KNIQKLNPYQ SARRIGGKGD TWLNANESPI SVPFKGKVKV    50
    FNRYPECQPN NLLSSYANYV GLLNNQILVT RGADEGIELL IKAFCEPGKD 100
    AIIYCPPTYD MYAINAKIAN VEIKEIPTFK NTWKIDLLNI RSNLNKVKLI 150
    YICNPNNPTG NIVSQEDLKS LLKVTLGQSL VIIDEAYIEF SPKNSMVNYL 200
    KTFPNLIILR TLSKAFALAG IRCGFTLAQK EVIDILHKVI SPYPISTLIA 250
    DIAVQSLEKK AIDDMKNRVL KLNMNRIWLI DELKKISCVK KVFDSHANYI 300
    LVEFYMFKKI FQSLWQKGII LRNQNHKNNL KNCLRISIGS KSECMRLVQE 350
    LKNFI 355
    Length:355
    Mass (Da):40,474
    Last modified:May 1, 1999 - v1
    Checksum:iC919301FE84D6DC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97356.1.
    AE013218 Genomic DNA. Translation: AAM67664.1.
    RefSeqiNP_660453.1. NC_004061.1.
    WP_011053630.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67664; AAM67664; BUsg_094.
    GeneIDi1005911.
    KEGGibas:BUsg094.
    PATRICi21246965. VBIBucAph100086_0097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97356.1 .
    AE013218 Genomic DNA. Translation: AAM67664.1 .
    RefSeqi NP_660453.1. NC_004061.1.
    WP_011053630.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q9ZHE5.
    SMRi Q9ZHE5. Positions 2-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg094.

    Proteomic databases

    PRIDEi Q9ZHE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67664 ; AAM67664 ; BUsg_094 .
    GeneIDi 1005911.
    KEGGi bas:BUsg094.
    PATRICi 21246965. VBIBucAph100086_0097.

    Phylogenomic databases

    eggNOGi COG0079.
    KOi K00817.
    OMAi RYECERV.
    OrthoDBi EOG651SWW.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00012 .
    BioCyci BAPH198804:GHMG-103-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01023. HisC_aminotrans_2.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01141. hisC. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
      Clark M.A., Baumann L., Baumann P.
      Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiHIS8_BUCAP
    AccessioniPrimary (citable) accession number: Q9ZHE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3