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Q9ZHE2

- HIS4_BUCAP

UniProt

Q9ZHE2 - HIS4_BUCAP

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei7 – 71Proton acceptorBy similarity
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-106-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Gene namesi
    Name:hisA
    Ordered Locus Names:BUsg_097
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2442441-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141988Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZHE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Phylogenomic databases

    eggNOGiCOG0106.
    KOiK01814.
    OMAiKSHEECL.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZHE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIPAFDLIN GEIVRLYKGN FFNRTKYDIN LYKRLKDYEI KGVKKIHLVD    50
    LDGAKNIKDR QIKVFRDIIS YTNIPIQIGG GIRNEEDINM FLNLGVKKVV 100
    IGSSAIKNKT KVKKWLKIYG PNVIILALDI IIKNNNKEIA IHGWQETTNI 150
    TLEEIIEYFS PIGLKHVLCT DISKDGTLSG PNNILYKDIV KKFKHISFQA 200
    SGGVSRLKDL LSLKKTGVKS VIIGRSLLEN KFTIEEALKC WQSE 244
    Length:244
    Mass (Da):27,775
    Last modified:May 1, 1999 - v1
    Checksum:i5F572E598F9EBCCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97359.1.
    AE013218 Genomic DNA. Translation: AAM67667.1.
    RefSeqiNP_660456.1. NC_004061.1.
    WP_011053633.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67667; AAM67667; BUsg_097.
    GeneIDi1005914.
    KEGGibas:BUsg097.
    PATRICi21246971. VBIBucAph100086_0100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067228 Genomic DNA. Translation: AAC97359.1 .
    AE013218 Genomic DNA. Translation: AAM67667.1 .
    RefSeqi NP_660456.1. NC_004061.1.
    WP_011053633.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q9ZHE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67667 ; AAM67667 ; BUsg_097 .
    GeneIDi 1005914.
    KEGGi bas:BUsg097.
    PATRICi 21246971. VBIBucAph100086_0100.

    Phylogenomic databases

    eggNOGi COG0106.
    KOi K01814.
    OMAi KSHEECL.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci BAPH198804:GHMG-106-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
      Clark M.A., Baumann L., Baumann P.
      Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiHIS4_BUCAP
    AccessioniPrimary (citable) accession number: Q9ZHE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3