Reviewed, UniProtKB/Swiss-Prot Q9ZHD9 (6PGD_BUCAP)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	BUsg_100

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090029
Experimental info
	Sequence conflict	158	1	K → N in AAC97362. Ref.1
	Sequence conflict	324 – 326	3	RRA → TKS in AAC97362. Ref.1
	Sequence conflict	348	1	K → I in AAC97362. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9ZHD9-1 [UniParc]. Last modified August 30, 2002. Version 2. Checksum: A11842A037E1E984	FASTA	473	53,805
	10 20 30 40 50 60 MLKQQVGVIG MAVMGRNLAL NIESKKYTVS IFNRTQSVTE EVINNNKEKK IFPYFSIKDF 70 80 90 100 110 120 VNSLRKPRCI LLMVKSGQPT DETIQFILPY LNKGDILIDG GNTFYKDSIR RSNDLMKCGI 130 140 150 160 170 180 NFIGMGVSGG ELGALNGPSI MPGGSREAYD LVSSMLKKIS AKFKNEPCVS YIGPNGAGHY 190 200 210 220 230 240 VKMIHNGIEY GDMQLISESY FILKNVLNMK NEELSNTFSQ WNKGELNSYL IEITKNIFLK 250 260 270 280 290 300 KEKDGIHYLI DSILDHAEDK GTGKWISQDA LELHEPLSLI TESVFARYLS SLKDQRLIAS 310 320 330 340 350 360 KILKGPILKC ISSQNKELFV EEVRRALYLG KIISYAQGFS QLKKASEKYS WNLQYGKIAK 370 380 390 400 410 420 IFRAGCIIRA DFLERITDAF KSNNVTNLLL TPYFSEISNK YEKSLRYITS YAIKYGIPVP 430 440 450 460 470 TFASAISYYD NYRTMSSSAN LIQAQRDYFG AHTYRRTDKK GYFHTNWLTK KEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis." Clark M.A., Baumann L., Baumann P. Curr. Microbiol. 37:356-358(1998) [PubMed: 9767718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF067228 Genomic DNA. Translation: AAC97362.1. AE013218 Genomic DNA. Translation: AAM67670.1.
RefSeq	NP_660459.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Genome annotation databases
GeneID	1005917.
GenomeReviews	Gene locus BUsg_100 in contig AE013218_GR.
KEGG	bas:BUsg100.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZHD9.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG100-MON.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DHase. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DHase_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

6PGD_BUCAP

Accession

Primary (citable) accession number: Q9ZHD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 30, 2002
Last modified:	November 4, 2008
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)