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Q9ZHD9 (6PGD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating
EC=1.1.1.44
Gene names
Name:gnd
Ordered Locus Names:BUsg_100
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4734736-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090029

Regions

Nucleotide binding10 – 156NADP By similarity
Nucleotide binding33 – 353NADP By similarity
Nucleotide binding74 – 763NADP By similarity
Region128 – 1303Substrate binding By similarity
Region185 – 1862Substrate binding By similarity

Sites

Active site1821Proton acceptor By similarity
Active site1891Proton donor By similarity
Binding site1021NADP By similarity
Binding site1021Substrate By similarity
Binding site1901Substrate By similarity
Binding site2601Substrate; via amide nitrogen By similarity
Binding site2871Substrate By similarity
Binding site4461Substrate; shared with dimeric partner By similarity
Binding site4521Substrate; shared with dimeric partner By similarity

Experimental info

Sequence conflict1581K → N in AAC97362. Ref.1
Sequence conflict324 – 3263RRA → TKS in AAC97362. Ref.1
Sequence conflict3481K → I in AAC97362. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9ZHD9 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: A11842A037E1E984

FASTA47353,805
        10         20         30         40         50         60 
MLKQQVGVIG MAVMGRNLAL NIESKKYTVS IFNRTQSVTE EVINNNKEKK IFPYFSIKDF 

        70         80         90        100        110        120 
VNSLRKPRCI LLMVKSGQPT DETIQFILPY LNKGDILIDG GNTFYKDSIR RSNDLMKCGI 

       130        140        150        160        170        180 
NFIGMGVSGG ELGALNGPSI MPGGSREAYD LVSSMLKKIS AKFKNEPCVS YIGPNGAGHY 

       190        200        210        220        230        240 
VKMIHNGIEY GDMQLISESY FILKNVLNMK NEELSNTFSQ WNKGELNSYL IEITKNIFLK 

       250        260        270        280        290        300 
KEKDGIHYLI DSILDHAEDK GTGKWISQDA LELHEPLSLI TESVFARYLS SLKDQRLIAS 

       310        320        330        340        350        360 
KILKGPILKC ISSQNKELFV EEVRRALYLG KIISYAQGFS QLKKASEKYS WNLQYGKIAK 

       370        380        390        400        410        420 
IFRAGCIIRA DFLERITDAF KSNNVTNLLL TPYFSEISNK YEKSLRYITS YAIKYGIPVP 

       430        440        450        460        470 
TFASAISYYD NYRTMSSSAN LIQAQRDYFG AHTYRRTDKK GYFHTNWLTK KEL

« Hide

References

« Hide 'large scale' references
[1]"Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
Clark M.A., Baumann L., Baumann P.
Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF067228 Genomic DNA. Translation: AAC97362.1.
AE013218 Genomic DNA. Translation: AAM67670.1.
RefSeqNP_660459.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ9ZHD9.
SMRQ9ZHD9. Positions 1-469.
ModBaseSearch...

Protein-protein interaction databases

STRING198804.BUsg100.

Proteomic databases

PRIDEQ9ZHD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67670; AAM67670; BUsg_100.
GeneID1005917.
KEGGbas:BUsg100.
PATRIC21246977. VBIBucAph100086_0103.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
KOK00033.
OMAKQQIGVI.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-171-MONOMER.
UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_BUCAP
AccessionPrimary (citable) accession number: Q9ZHD9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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