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Q9ZHD9

- 6PGD_BUCAP

UniProt

Q9ZHD9 - 6PGD_BUCAP

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Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
gnd, BUsg_100
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADP By similarity
Binding sitei102 – 1021Substrate By similarity
Active sitei182 – 1821Proton acceptor By similarity
Active sitei189 – 1891Proton donor By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei260 – 2601Substrate; via amide nitrogen By similarity
Binding sitei287 – 2871Substrate By similarity
Binding sitei446 – 4461Substrate; shared with dimeric partner By similarity
Binding sitei452 – 4521Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity
Nucleotide bindingi33 – 353NADP By similarity
Nucleotide bindingi74 – 763NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-109-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:BUsg_100
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4734736-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090029Add
BLAST

Proteomic databases

PRIDEiQ9ZHD9.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg100.

Structurei

3D structure databases

ProteinModelPortaliQ9ZHD9.
SMRiQ9ZHD9. Positions 1-469.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate binding By similarity
Regioni185 – 1862Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHD9-1 [UniParc]FASTAAdd to Basket

« Hide

MLKQQVGVIG MAVMGRNLAL NIESKKYTVS IFNRTQSVTE EVINNNKEKK    50
IFPYFSIKDF VNSLRKPRCI LLMVKSGQPT DETIQFILPY LNKGDILIDG 100
GNTFYKDSIR RSNDLMKCGI NFIGMGVSGG ELGALNGPSI MPGGSREAYD 150
LVSSMLKKIS AKFKNEPCVS YIGPNGAGHY VKMIHNGIEY GDMQLISESY 200
FILKNVLNMK NEELSNTFSQ WNKGELNSYL IEITKNIFLK KEKDGIHYLI 250
DSILDHAEDK GTGKWISQDA LELHEPLSLI TESVFARYLS SLKDQRLIAS 300
KILKGPILKC ISSQNKELFV EEVRRALYLG KIISYAQGFS QLKKASEKYS 350
WNLQYGKIAK IFRAGCIIRA DFLERITDAF KSNNVTNLLL TPYFSEISNK 400
YEKSLRYITS YAIKYGIPVP TFASAISYYD NYRTMSSSAN LIQAQRDYFG 450
AHTYRRTDKK GYFHTNWLTK KEL 473
Length:473
Mass (Da):53,805
Last modified:August 30, 2002 - v2
Checksum:iA11842A037E1E984
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581K → N in AAC97362. 1 Publication
Sequence conflicti324 – 3263RRA → TKS in AAC97362. 1 Publication
Sequence conflicti348 – 3481K → I in AAC97362. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067228 Genomic DNA. Translation: AAC97362.1.
AE013218 Genomic DNA. Translation: AAM67670.1.
RefSeqiNP_660459.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67670; AAM67670; BUsg_100.
GeneIDi1005917.
KEGGibas:BUsg100.
PATRICi21246977. VBIBucAph100086_0103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067228 Genomic DNA. Translation: AAC97362.1 .
AE013218 Genomic DNA. Translation: AAM67670.1 .
RefSeqi NP_660459.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q9ZHD9.
SMRi Q9ZHD9. Positions 1-469.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198804.BUsg100.

Proteomic databases

PRIDEi Q9ZHD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67670 ; AAM67670 ; BUsg_100 .
GeneIDi 1005917.
KEGGi bas:BUsg100.
PATRICi 21246977. VBIBucAph100086_0103.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci BAPH198804:GHMG-109-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Buchnera aphidicola (Aphid endosymbiont) contains genes encoding enzymes of histidine biosynthesis."
    Clark M.A., Baumann L., Baumann P.
    Curr. Microbiol. 37:356-358(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry namei6PGD_BUCAP
AccessioniPrimary (citable) accession number: Q9ZHD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: May 14, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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