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Protein

Silver exporting P-type ATPase

Gene

silP

Organism
Salmonella typhimurium
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sil cation-efflux system that confers resistance to silver.

Catalytic activityi

ATP + H2O + Ag+(In) = ADP + phosphate + Ag+(Out).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5114-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Metal-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.3.5.4 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Silver exporting P-type ATPase (EC:3.6.3.53)
Gene namesi
Name:silP
Encoded oniPlasmid pMG1010 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463311 – 824Silver exporting P-type ATPaseAdd BLAST824

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9ZHC7
SMRiQ9ZHC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 99Poly-His8
Compositional biasi799 – 804Poly-Ala6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.620.20, 1 hit
3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
IPR012348 RNR-like
IPR011017 TRASH_dom
IPR007029 YHS_dom
PfamiView protein in Pfam
PF04945 YHS, 1 hit
SMARTiView protein in SMART
SM00746 TRASH, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 2 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZHC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQICIRRVT VKNDNAVEHN NQDCFLSRTS SRDESHALHK VRESVCGMVI
60 70 80 90 100
LPDKAHSSIR YQDHQLYFCS ASCESKFKAH PDHYFTEDAS EHHHHHDHHE
110 120 130 140 150
VSPDKIKQSH RQAEKEISEG VWTCPMHPEI RRSGPGSCPV CGMALEPLVA
160 170 180 190 200
TASTGTSDEL RDMTRRFWLG LLLAFPVLIL EMGSHLFPAL RNTVPPQYNT
210 220 230 240 250
WLQLLLASPV VLWCGWPFFA RAGMSLRNRS LNMFTLVAMG TGVAWVYSVI
260 270 280 290 300
ATVFPSWFPA SFRNMDGLVA IYFEAAAVIT VLVLLGQVLE LRAREQTSGA
310 320 330 340 350
ITALLNLAPK TARRLDQDGH ETDINAEDVL PGDKLRIRPG ESIPVDGIVV
360 370 380 390 400
EGKTTVDESM VTGESMPVTK TEGEPVIGGT INQTGSLIIR AEKVGDETML
410 420 430 440 450
SRIVQMVADA QRSRAPIQRM ADSVSGWFVP LVILIAVVAF MIWSVWGPEP
460 470 480 490 500
RMAHGLIAAV SVLIIACPCA LGLATPMSIM VGVGKGAQAG VLIKNAEALE
510 520 530 540 550
RLEKVDTLVV DKTGTLTEGS PTVTGIISLN PGGETSLLRV TAAVDKGSQH
560 570 580 590 600
PLGMAVVKAA QEKGIAIPAV THFNAPSGKG VSGDVEGQRV VIGNELAMQE
610 620 630 640 650
NSIVIDNQKA VADTLRMEGT TVIYVATDGH LAGLIAISDP VKATTPDALK
660 670 680 690 700
ALRQAGIRIV MLTGDNQLTA EAVARKLGID EVEAGILPDG KKAVITRLKA
710 720 730 740 750
SGHVVAMAGD GVNDAPALAA ADVGIAMGTG TDVAIESAGV TLLKGDLMIL
760 770 780 790 800
NRARHLSEIT MKNIRQNLFF AFIYNALGVP VAAGLLYPVY GILLSPVIAA
810 820
AAMALSSVSV IVNALRLKSV RLGK
Length:824
Mass (Da):88,221
Last modified:May 1, 1999 - v1
Checksum:i56A983D256C9AD1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067954 Genomic DNA Translation: AAD11750.1

Genome annotation databases

KEGGiag:AAD11750

Similar proteinsi

Entry informationi

Entry nameiSILP_SALTM
AccessioniPrimary (citable) accession number: Q9ZHC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
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Main funding by: National Institutes of Health