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Protein

Silver exporting P-type ATPase

Gene

silP

Organism
Salmonella typhimurium
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the sil cation-efflux system that confers resistance to silver.

Catalytic activityi

ATP + H2O + Ag+(In) = ADP + phosphate + Ag+(Out).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5114-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.3.5.4. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Silver exporting P-type ATPase (EC:3.6.3.53)
Gene namesi
Name:silP
Encoded oniPlasmid pMG1010 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463311 – 824Silver exporting P-type ATPaseAdd BLAST824

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9ZHC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 99Poly-His8
Compositional biasi799 – 804Poly-Ala6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
IPR011017. TRASH_dom.
IPR007029. YHS_dom.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF04945. YHS. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZHC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQICIRRVT VKNDNAVEHN NQDCFLSRTS SRDESHALHK VRESVCGMVI
60 70 80 90 100
LPDKAHSSIR YQDHQLYFCS ASCESKFKAH PDHYFTEDAS EHHHHHDHHE
110 120 130 140 150
VSPDKIKQSH RQAEKEISEG VWTCPMHPEI RRSGPGSCPV CGMALEPLVA
160 170 180 190 200
TASTGTSDEL RDMTRRFWLG LLLAFPVLIL EMGSHLFPAL RNTVPPQYNT
210 220 230 240 250
WLQLLLASPV VLWCGWPFFA RAGMSLRNRS LNMFTLVAMG TGVAWVYSVI
260 270 280 290 300
ATVFPSWFPA SFRNMDGLVA IYFEAAAVIT VLVLLGQVLE LRAREQTSGA
310 320 330 340 350
ITALLNLAPK TARRLDQDGH ETDINAEDVL PGDKLRIRPG ESIPVDGIVV
360 370 380 390 400
EGKTTVDESM VTGESMPVTK TEGEPVIGGT INQTGSLIIR AEKVGDETML
410 420 430 440 450
SRIVQMVADA QRSRAPIQRM ADSVSGWFVP LVILIAVVAF MIWSVWGPEP
460 470 480 490 500
RMAHGLIAAV SVLIIACPCA LGLATPMSIM VGVGKGAQAG VLIKNAEALE
510 520 530 540 550
RLEKVDTLVV DKTGTLTEGS PTVTGIISLN PGGETSLLRV TAAVDKGSQH
560 570 580 590 600
PLGMAVVKAA QEKGIAIPAV THFNAPSGKG VSGDVEGQRV VIGNELAMQE
610 620 630 640 650
NSIVIDNQKA VADTLRMEGT TVIYVATDGH LAGLIAISDP VKATTPDALK
660 670 680 690 700
ALRQAGIRIV MLTGDNQLTA EAVARKLGID EVEAGILPDG KKAVITRLKA
710 720 730 740 750
SGHVVAMAGD GVNDAPALAA ADVGIAMGTG TDVAIESAGV TLLKGDLMIL
760 770 780 790 800
NRARHLSEIT MKNIRQNLFF AFIYNALGVP VAAGLLYPVY GILLSPVIAA
810 820
AAMALSSVSV IVNALRLKSV RLGK
Length:824
Mass (Da):88,221
Last modified:May 1, 1999 - v1
Checksum:i56A983D256C9AD1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067954 Genomic DNA. Translation: AAD11750.1.

Genome annotation databases

KEGGiag:AAD11750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067954 Genomic DNA. Translation: AAD11750.1.

3D structure databases

ProteinModelPortaliQ9ZHC7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.3.5.4. the p-type atpase (p-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAD11750.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
IPR011017. TRASH_dom.
IPR007029. YHS_dom.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF04945. YHS. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSILP_SALTM
AccessioniPrimary (citable) accession number: Q9ZHC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.