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Q9ZH77

- MASY_STRC2

UniProt

Q9ZH77 - MASY_STRC2

Protein

Malate synthase

Gene

aceB

Organism
Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691Proton acceptorBy similarity
    Active sitei454 – 4541Proton donorBy similarity

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    BRENDAi2.3.3.9. 5988.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase (EC:2.3.3.9)
    Gene namesi
    Name:aceB
    OrganismiStreptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
    Taxonomic identifieri443255 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Malate synthasePRO_0000166878Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZH77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malate synthase family.Curated

    Family and domain databases

    InterProiIPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001363. Malate_synth. 1 hit.
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
    PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZH77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASAPSRPA VVTAPAVPRQ DEVLTEAALV FLAELHRRFT PRRDELLARR    50
    ARRRAEISRT GTLDFLPETA HVRADDSWRV APAPPALQDR RVEITGPADR 100
    RMTVNALNSG ARVWLADFED SSAPTWENVI SGQLALSDAY HRRIDFTDER 150
    SGKSYALRPD AELATVVMRP RGWHLPERHL TGPDGGVLPG ALVDFGLCFF 200
    HTARRLLDLG KGPYFYLPKL ESHQEARLWN DIFLFAQEQL GIPRGTIRAT 250
    VLIETITAAY EMEEILYELR EHASGLNAGR WDYLFSIIKN FRDAGPGFVL 300
    PDRNAITMTA PFMRAYTELL VRTCHRRGAH AIGGMAAFIP SRRDPEINRA 350
    AFEKVRADKD REAADGFDGS WVAHPDLVPV ALASFDAVLG DRPHQKDRLR 400
    EEVSVTAAEL IAVGSPAARP TAAGLLNAVR VGIRYIEAWL RGTGAVAIFH 450
    LMEDAATAEI SRSQIWQWIN AGVVLENGER VTPALVRTLA AGELGALRET 500
    LGGEEYAAGR WQEAHDLLLR VALDEEYADF LTLPAYERLT G 541
    Length:541
    Mass (Da):60,012
    Last modified:May 1, 1999 - v1
    Checksum:i26206E19BB4B8395
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070989 Genomic DNA. Translation: AAC83648.1.
    RefSeqiWP_003954464.1. NZ_DS570636.1.

    Genome annotation databases

    PATRICi29744904. VBIStrCla15562_1804.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070989 Genomic DNA. Translation: AAC83648.1 .
    RefSeqi WP_003954464.1. NZ_DS570636.1.

    3D structure databases

    ProteinModelPortali Q9ZH77.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    PATRICi 29744904. VBIStrCla15562_1804.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BRENDAi 2.3.3.9. 5988.

    Family and domain databases

    InterProi IPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001363. Malate_synth. 1 hit.
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
    PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate."
      Chan M., Sim T.S.
      Microbiology 144:3229-3237(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602.

    Entry informationi

    Entry nameiMASY_STRC2
    AccessioniPrimary (citable) accession number: Q9ZH77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3