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Q9ZGI5

- Q9ZGI5_STRVZ

UniProt

Q9ZGI5 - Q9ZGI5_STRVZ

Protein
Submitted name:

Type I polyketide synthase PikAI

Gene

pikAI

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphopantetheine binding Source: InterPro
    2. transferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18411.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Type I polyketide synthase PikAIImported
    Gene namesi
    Name:pikAIImported
    OrganismiStreptomyces venezuelaeImported
    Taxonomic identifieri54571 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZGI5.
    SMRiQ9ZGI5. Positions 1108-1990, 4393-4482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.10. 3 hits.
    3.40.366.10. 7 hits.
    3.40.47.10. 6 hits.
    3.40.50.720. 3 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 3 hits.
    PF00109. ketoacyl-synt. 3 hits.
    PF02801. Ketoacyl-synt_C. 3 hits.
    PF08659. KR. 2 hits.
    PF00550. PP-binding. 3 hits.
    [Graphical view]
    SMARTiSM00827. PKS_AT. 3 hits.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 2 hits.
    SM00825. PKS_KS. 3 hits.
    SM00823. PKS_PP. 3 hits.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 3 hits.
    SSF52151. SSF52151. 6 hits.
    SSF53901. SSF53901. 6 hits.
    SSF55048. SSF55048. 3 hits.
    PROSITEiPS50075. ACP_DOMAIN. 3 hits.
    PS00606. B_KETOACYL_SYNTHASE. 2 hits.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZGI5-1 [UniParc]FASTAAdd to Basket

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    MSSAGITRTG ARTPVTGRGA AAWDTGEVRV RRGLPPAGPD HAEHSFSRAP     50
    TGDVRAELIR GEMSTVSKSE SEEFVSVSND AGSAHGTAEP VAVVGISCRV 100
    PGARDPREFW ELLAAGGQAV TDVPADRWNA GDFYDPDRSA PGRSNSRWGG 150
    FIEDVDRFDA AFFGISPREA AEMDPQQRLA LELGWEALER AGIDPSSLTG 200
    TRTGVFAGAI WDDYATLKHR QGGAAITPHT VTGLHRGIIA NRLSYTLGLR 250
    GPSMVVDSGQ SSSLVAVHLA CESLRRGESE LALAGGVSLN LVPDSIIGAS 300
    KFGGLSPDGR AYTFDARANG YVRGEGGGFV VLKRLSRAVA DGDPVLAVIR 350
    GSAVNNGGAA QGMTTPDAQA QEAVLREAHE RAGTAPADVR YVELHGTGTP 400
    VGDPIEAAAL GAALGTGRPA GQPLLVGSVK TNIGHLEGAA GIAGLIKAVL 450
    AVRGRALPAS LNYETPNPAI PFEELNLRVN TEYLPWEPEH DGQRMVVGVS 500
    SFGMGGTNAH VVLEEAPGGC RGASVVESTV GGSAVGGGVV PWVVSAKSAA 550
    ALDAQIERLA AFASRDRTDG VDAGAVDAGA VDAGAVARVL AGGRAQFEHR 600
    AVVVGSGPDD LAAALAAPEG LVRGVASGVG RVAFVFPGQG TQWAGMGAEL 650
    LDSSAVFAAA MAECEAALSP YVDWSLEAVV RQAPGAPTLE RVDVVQPVTF 700
    AVMVSLARVW QHHGVTPQAV VGHSQGEIAA AYVAGALSLD DAARVVTLRS 750
    KSIAAHLAGK GGMLSLALSE DAVLERLAGF DGLSVAAVNG PTATVVSGDP 800
    VQIEELARAC EADGVRARVI PVDYASHSRQ VEIIESELAE VLAGLSPQAP 850
    RVPFFSTLEG AWITEPVLDG GYWYRNLRHR VGFAPAVETL ATDEGFTHFV 900
    EVSAHPVLTM ALPGTVTGLA TLRRDNGGQD RLVASLAEAW ANGLAVDWSP 950
    LLPSATGHHS DLPTYAFQTE RHWLGEIEAL APAGEPAVQP AVLRTEAAEP 1000
    AELDRDEQLR VILDKVRAQT AQVLGYATGG QIEVDRTFRE AGCTSLTGVD 1050
    LRNRINAAFG VRMAPSMIFD FPTPEALAEQ LLLVVHGEAA ANPAGAEPAP 1100
    VAAAGAVDEP VAIVGMACRL PGGVASPEDL WRLVAGGGDA ISEFPQDRGW 1150
    DVEGLYHPDP EHPGTSYVRQ GGFIENVAGF DAAFFGISPR EALAMDPQQR 1200
    LLLETSWEAV EDAGIDPTSL RGRQVGVFTG AMTHEYGPSL RDGGEGLDGY 1250
    LLTGNTASVM SGRVSYTLGL EGPALTVDTA CSSSLVALHL AVQALRKGEV 1300
    DMALAGGVAV MPTPGMFVEF SRQRGLAGDG RSKAFAASAD GTSWSEGVGV 1350
    LLVERLSDAR RNGHQVLAVV RGSALNQDGA SNGLTAPNGP SQQRVIRRAL 1400
    ADARLTTSDV DVVEAHGTGT RLGDPIEAQA LIATYGQGRD DEQPLRLGSL 1450
    KSNIGHTQAA AGVSGVIKMV QAMRHGLLPK TLHVDEPSDQ IDWSAGAVEL 1500
    LTEAVDWPEK QDGGLRRAAV SSFGISGTNA HVVLEEAPVV VEGASVVEPS 1550
    VGGSAVGGGV TPWVVSAKSA AALDAQIERL AAFASRDRTD DADAGAVDAG 1600
    AVAHVLADGR AQFEHRAVAL GAGADDLVQA LADPDGLIRG TASGVGRVAF 1650
    VFPGQGTQWA GMGAELLDSS AVFAAAMAEC EAALSPYVDW SLEAVVRQAP 1700
    GAPTLERVDV VQPVTFAVMV SLARVWQHHG VTPQAVVGHS QGEIAAAYVA 1750
    GALPLDDAAR VVTLRSKSIA AHLAGKGGML SLALNEDAVL ERLSDFDGLS 1800
    VAAVNGPTAT VVSGDPVQIE ELAQACKADG FRARIIPVDY ASHSRQVEII 1850
    ESELAQVLAG LSPQAPRVPF FSTLEGTWIT EPVLDGTYWY RNLRHRVGFA 1900
    PAIETLAVDE GFTHFVEVSA HPVLTMTLPE TVTGLGTLRR EQGGQERLVT 1950
    SLAEAWVNGL PVAWTSLLPA TASRPGLPTY AFQAERYWLE NTPAALATGD 2000
    DWRYRIDWKR LPAAEGSERT GLSGRWLAVT PEDHSAQAAA VLTALVDAGA 2050
    KVEVLTAGAD DDREALAARL TALTTGDGFT GVVSLLDGLV PQVAWVQALG 2100
    DAGIKAPLWS VTQGAVSVGR LDTPADPDRA MLWGLGRVVA LEHPERWAGL 2150
    VDLPAQPDAA ALAHLVTALS GATGEDQIAI RTTGLHARRL ARAPLHGRRP 2200
    TRDWQPHGTV LITGGTGALG SHAARWMAHH GAEHLLLVSR SGEQAPGATQ 2250
    LTAELTASGA RVTIAACDVA DPHAMRTLLD AIPAETPLTA VVHTAGALDD 2300
    GIVDTLTAEQ VRRAHRAKAV GASVLDELTR DLDLDAFVLF SSVSSTLGIP 2350
    GQGNYAPHNA YLDALAARRR ATGRSAVSVA WGPWDGGGMA AGDGVAERLR 2400
    NHGVPGMDPE LALAALESAL GRDETAITVA DIDWDRFYLA YSSGRPQPLV 2450
    EELPEVRRII DARDSATSGQ GGSSAQGANP LAERLAAAAP GERTEILLGL 2500
    VRAQAAAVLR MRSPEDVAAD RAFKDIGFDS LAGVELRNRL TRATGLQLPA 2550
    TLVFDHPTPL ALVSLLRSEF LGDEETADAR RSAALPATVG AGAGAGAGTD 2600
    ADDDPIAIVA MSCRYPGDIR SPEDLWRMLS EGGEGITPFP TDRGWDLDGL 2650
    YDADPDALGR AYVREGGFLH DAAEFDAEFF GVSPREALAM DPQQRMLLTT 2700
    SWEAFERAGI EPASLRGSST GVFIGLSYQD YAARVPNAPR GVEGYLLTGS 2750
    TPSVASGRIA YTFGLEGPAT TVDTACSSSL TALHLAVRAL RSGECTMALA 2800
    GGVAMMATPH MFVEFSRQRA LAPDGRSKAF SADADGFGAA EGVGLLLVER 2850
    LSDARRNGHP VLAVVRGTAV NQDGASNGLT APNGPSQQRV IRQALADARL 2900
    APGDIDAVET HGTGTSLGDP IEAQGLQATY GKERPAERPL AIGSVKSNIG 2950
    HTQAAAGAAG IIKMVLAMRH GTLPKTLHAD EPSPHVDWAN SGLALVTEPI 3000
    DWPAGTGPRR AAVSSFGISG TNAHVVLEQA PDAAGEVLGA DEVPEVSETV 3050
    AMAGTAGTSE VAEGSEASEA PAAPGSREAS LPGHLPWVLS AKDEQSLRGQ 3100
    AAALHAWLSE PAADLSDADG PARLRDVGYT LATSRTAFAH RAAVTAADRD 3150
    GFLDGLATLA QGGTSAHVHL DTARDGTTAF LFTGQGSQRP GAGRELYDRH 3200
    PVFARALDEI CAHLDGHLEL PLLDVMFAAE GSAEAALLDE TRYTQCALFA 3250
    LEVALFRLVE SWGMRPAALL GHSVGEIAAA HVAGVFSLAD AARLVAARGR 3300
    LMQELPAGGA MLAVQAAEDE IRVWLETEER YAGRLDVAAV NGPEAAVLSG 3350
    DADAAREAEA YWSGLGRRTR ALRVSHAFHS AHMDGMLDGF RAVLETVEFR 3400
    RPSLTVVSNV TGLAAGPDDL CDPEYWVRHV RGTVRFLDGV RVLRDLGVRT 3450
    CLELGPDGVL TAMAADGLAD TPADSAAGSP VGSPAGSPAD SAAGALRPRP 3500
    LLVALLRRKR SETETVADAL GRAHAHGTGP DWHAWFAGSG AHRVDLPTYS 3550
    FRRDRYWLDA PAADTAVDTA GLGLGTADHP LLGAVVSLPD RDGLLLTGRL 3600
    SLRTHPWLAD HAVLGSVLLP GAAMVELAAH AAESAGLRDV RELTLLEPLV 3650
    LPEHGGVELR VTVGAPAGEP GGESAGDGAR PVSLHSRLAD APAGTAWSCH 3700
    ATGLLATDRP ELPVAPDRAA MWPPQGAEEV PLDGLYERLD GNGLAFGPLF 3750
    QGLNAVWRYE GEVFADIALP ATTNATAPAT ANGGGSAAAA PYGIHPALLD 3800
    ASLHAIAVGG LVDEPELVRV PFHWSGVTVH AAGAAAARVR LASAGTDAVS 3850
    LSLTDGEGRP LVSVERLTLR PVTADQAAAS RVGGLMHRVA WRPYALASSG 3900
    EQDPHATSYG PTAVLGKDEL KVAAALESAG VEVGLYPDLA ALSQDVAAGA 3950
    PAPRTVLAPL PAGPADGGAE GVRGTVARTL ELLQAWLADE HLAGTRLLLV 4000
    TRGAVRDPEG SGADDGGEDL SHAAAWGLVR TAQTENPGRF GLLDLADDAS 4050
    SYRTLPSVLS DAGLRDEPQL ALHDGTIRLA RLASVRPETG TAAPALAPEG 4100
    TVLLTGGTGG LGGLVARHVV GEWGVRRLLL VSRRGTDAPG ADELVHELEA 4150
    LGADVSVAAC DVADREALTA VLDAIPAEHP LTAVVHTAGV LSDGTLPSMT 4200
    TEDVEHVLRP KVDAAFLLDE LTSTPAYDLA AFVMFSSAAA VFGGAGQGAY 4250
    AAANATLDAL AWRRRAAGLP ALSLGWGLWA ETSGMTGELG QADLRRMSRA 4300
    GIGGISDAEG IALLDAALRD DRHPVLLPLR LDAAGLRDAA GNDPAGIPAL 4350
    FRDVVGARTV RARPSAASAS TTAGTAGTPG TADGAAETAA VTLADRAATV 4400
    DGPARQRLLL EFVVGEVAEV LGHARGHRID AERGFLDLGF DSLTAVELRN 4450
    RLNSAGGLAL PATLVFDHPS PAALASHLDA ELPRGASDQD GAGNRNGNEN 4500
    GTTASRSTAE TDALLAQLTR LEGALVLTGL SDAPGSEEVL EHLRSLRSMV 4550
    TGETGTGTAS GAPDGAGSGA EDRPWAAGDG AGGGSEDGAG VPDFMNASAE 4600
    ELFGLLDQDP STD 4613
    Length:4,613
    Mass (Da):477,293
    Last modified:May 1, 1999 - v1
    Checksum:iA3BAF8D37CEC9383
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69329.1.
    PIRiT17409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69329.1 .
    PIRi T17409.

    3D structure databases

    ProteinModelPortali Q9ZGI5.
    SMRi Q9ZGI5. Positions 1108-1990, 4393-4482.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-18411.

    Family and domain databases

    Gene3Di 1.10.1200.10. 3 hits.
    3.40.366.10. 7 hits.
    3.40.47.10. 6 hits.
    3.40.50.720. 3 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 3 hits.
    PF00109. ketoacyl-synt. 3 hits.
    PF02801. Ketoacyl-synt_C. 3 hits.
    PF08659. KR. 2 hits.
    PF00550. PP-binding. 3 hits.
    [Graphical view ]
    SMARTi SM00827. PKS_AT. 3 hits.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 2 hits.
    SM00825. PKS_KS. 3 hits.
    SM00823. PKS_PP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 3 hits.
    SSF52151. SSF52151. 6 hits.
    SSF53901. SSF53901. 6 hits.
    SSF55048. SSF55048. 3 hits.
    PROSITEi PS50075. ACP_DOMAIN. 3 hits.
    PS00606. B_KETOACYL_SYNTHASE. 2 hits.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
      Xue Y., Zhao L., Liu H.W., Sherman D.H.
      Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15439Imported.

    Entry informationi

    Entry nameiQ9ZGI5_STRVZ
    AccessioniPrimary (citable) accession number: Q9ZGI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)