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Q9ZGI5

- Q9ZGI5_STRVZ

UniProt

Q9ZGI5 - Q9ZGI5_STRVZ

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Protein
Submitted name:

Type I polyketide synthase PikAI

Gene

pikAI

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. phosphopantetheine binding Source: InterPro
  2. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18411.

Names & Taxonomyi

Protein namesi
Submitted name:
Type I polyketide synthase PikAIImported
Gene namesi
Name:pikAIImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9ZGI5.
SMRiQ9ZGI5. Positions 1108-1990, 4393-4482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 3 hits.
3.40.366.10. 7 hits.
3.40.47.10. 6 hits.
3.40.50.720. 3 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 3 hits.
PF00109. ketoacyl-synt. 3 hits.
PF02801. Ketoacyl-synt_C. 3 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 3 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 3 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 3 hits.
SM00823. PKS_PP. 3 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 3 hits.
SSF52151. SSF52151. 6 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 3 hits.
PROSITEiPS50075. ACP_DOMAIN. 3 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZGI5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSSAGITRTG ARTPVTGRGA AAWDTGEVRV RRGLPPAGPD HAEHSFSRAP
60 70 80 90 100
TGDVRAELIR GEMSTVSKSE SEEFVSVSND AGSAHGTAEP VAVVGISCRV
110 120 130 140 150
PGARDPREFW ELLAAGGQAV TDVPADRWNA GDFYDPDRSA PGRSNSRWGG
160 170 180 190 200
FIEDVDRFDA AFFGISPREA AEMDPQQRLA LELGWEALER AGIDPSSLTG
210 220 230 240 250
TRTGVFAGAI WDDYATLKHR QGGAAITPHT VTGLHRGIIA NRLSYTLGLR
260 270 280 290 300
GPSMVVDSGQ SSSLVAVHLA CESLRRGESE LALAGGVSLN LVPDSIIGAS
310 320 330 340 350
KFGGLSPDGR AYTFDARANG YVRGEGGGFV VLKRLSRAVA DGDPVLAVIR
360 370 380 390 400
GSAVNNGGAA QGMTTPDAQA QEAVLREAHE RAGTAPADVR YVELHGTGTP
410 420 430 440 450
VGDPIEAAAL GAALGTGRPA GQPLLVGSVK TNIGHLEGAA GIAGLIKAVL
460 470 480 490 500
AVRGRALPAS LNYETPNPAI PFEELNLRVN TEYLPWEPEH DGQRMVVGVS
510 520 530 540 550
SFGMGGTNAH VVLEEAPGGC RGASVVESTV GGSAVGGGVV PWVVSAKSAA
560 570 580 590 600
ALDAQIERLA AFASRDRTDG VDAGAVDAGA VDAGAVARVL AGGRAQFEHR
610 620 630 640 650
AVVVGSGPDD LAAALAAPEG LVRGVASGVG RVAFVFPGQG TQWAGMGAEL
660 670 680 690 700
LDSSAVFAAA MAECEAALSP YVDWSLEAVV RQAPGAPTLE RVDVVQPVTF
710 720 730 740 750
AVMVSLARVW QHHGVTPQAV VGHSQGEIAA AYVAGALSLD DAARVVTLRS
760 770 780 790 800
KSIAAHLAGK GGMLSLALSE DAVLERLAGF DGLSVAAVNG PTATVVSGDP
810 820 830 840 850
VQIEELARAC EADGVRARVI PVDYASHSRQ VEIIESELAE VLAGLSPQAP
860 870 880 890 900
RVPFFSTLEG AWITEPVLDG GYWYRNLRHR VGFAPAVETL ATDEGFTHFV
910 920 930 940 950
EVSAHPVLTM ALPGTVTGLA TLRRDNGGQD RLVASLAEAW ANGLAVDWSP
960 970 980 990 1000
LLPSATGHHS DLPTYAFQTE RHWLGEIEAL APAGEPAVQP AVLRTEAAEP
1010 1020 1030 1040 1050
AELDRDEQLR VILDKVRAQT AQVLGYATGG QIEVDRTFRE AGCTSLTGVD
1060 1070 1080 1090 1100
LRNRINAAFG VRMAPSMIFD FPTPEALAEQ LLLVVHGEAA ANPAGAEPAP
1110 1120 1130 1140 1150
VAAAGAVDEP VAIVGMACRL PGGVASPEDL WRLVAGGGDA ISEFPQDRGW
1160 1170 1180 1190 1200
DVEGLYHPDP EHPGTSYVRQ GGFIENVAGF DAAFFGISPR EALAMDPQQR
1210 1220 1230 1240 1250
LLLETSWEAV EDAGIDPTSL RGRQVGVFTG AMTHEYGPSL RDGGEGLDGY
1260 1270 1280 1290 1300
LLTGNTASVM SGRVSYTLGL EGPALTVDTA CSSSLVALHL AVQALRKGEV
1310 1320 1330 1340 1350
DMALAGGVAV MPTPGMFVEF SRQRGLAGDG RSKAFAASAD GTSWSEGVGV
1360 1370 1380 1390 1400
LLVERLSDAR RNGHQVLAVV RGSALNQDGA SNGLTAPNGP SQQRVIRRAL
1410 1420 1430 1440 1450
ADARLTTSDV DVVEAHGTGT RLGDPIEAQA LIATYGQGRD DEQPLRLGSL
1460 1470 1480 1490 1500
KSNIGHTQAA AGVSGVIKMV QAMRHGLLPK TLHVDEPSDQ IDWSAGAVEL
1510 1520 1530 1540 1550
LTEAVDWPEK QDGGLRRAAV SSFGISGTNA HVVLEEAPVV VEGASVVEPS
1560 1570 1580 1590 1600
VGGSAVGGGV TPWVVSAKSA AALDAQIERL AAFASRDRTD DADAGAVDAG
1610 1620 1630 1640 1650
AVAHVLADGR AQFEHRAVAL GAGADDLVQA LADPDGLIRG TASGVGRVAF
1660 1670 1680 1690 1700
VFPGQGTQWA GMGAELLDSS AVFAAAMAEC EAALSPYVDW SLEAVVRQAP
1710 1720 1730 1740 1750
GAPTLERVDV VQPVTFAVMV SLARVWQHHG VTPQAVVGHS QGEIAAAYVA
1760 1770 1780 1790 1800
GALPLDDAAR VVTLRSKSIA AHLAGKGGML SLALNEDAVL ERLSDFDGLS
1810 1820 1830 1840 1850
VAAVNGPTAT VVSGDPVQIE ELAQACKADG FRARIIPVDY ASHSRQVEII
1860 1870 1880 1890 1900
ESELAQVLAG LSPQAPRVPF FSTLEGTWIT EPVLDGTYWY RNLRHRVGFA
1910 1920 1930 1940 1950
PAIETLAVDE GFTHFVEVSA HPVLTMTLPE TVTGLGTLRR EQGGQERLVT
1960 1970 1980 1990 2000
SLAEAWVNGL PVAWTSLLPA TASRPGLPTY AFQAERYWLE NTPAALATGD
2010 2020 2030 2040 2050
DWRYRIDWKR LPAAEGSERT GLSGRWLAVT PEDHSAQAAA VLTALVDAGA
2060 2070 2080 2090 2100
KVEVLTAGAD DDREALAARL TALTTGDGFT GVVSLLDGLV PQVAWVQALG
2110 2120 2130 2140 2150
DAGIKAPLWS VTQGAVSVGR LDTPADPDRA MLWGLGRVVA LEHPERWAGL
2160 2170 2180 2190 2200
VDLPAQPDAA ALAHLVTALS GATGEDQIAI RTTGLHARRL ARAPLHGRRP
2210 2220 2230 2240 2250
TRDWQPHGTV LITGGTGALG SHAARWMAHH GAEHLLLVSR SGEQAPGATQ
2260 2270 2280 2290 2300
LTAELTASGA RVTIAACDVA DPHAMRTLLD AIPAETPLTA VVHTAGALDD
2310 2320 2330 2340 2350
GIVDTLTAEQ VRRAHRAKAV GASVLDELTR DLDLDAFVLF SSVSSTLGIP
2360 2370 2380 2390 2400
GQGNYAPHNA YLDALAARRR ATGRSAVSVA WGPWDGGGMA AGDGVAERLR
2410 2420 2430 2440 2450
NHGVPGMDPE LALAALESAL GRDETAITVA DIDWDRFYLA YSSGRPQPLV
2460 2470 2480 2490 2500
EELPEVRRII DARDSATSGQ GGSSAQGANP LAERLAAAAP GERTEILLGL
2510 2520 2530 2540 2550
VRAQAAAVLR MRSPEDVAAD RAFKDIGFDS LAGVELRNRL TRATGLQLPA
2560 2570 2580 2590 2600
TLVFDHPTPL ALVSLLRSEF LGDEETADAR RSAALPATVG AGAGAGAGTD
2610 2620 2630 2640 2650
ADDDPIAIVA MSCRYPGDIR SPEDLWRMLS EGGEGITPFP TDRGWDLDGL
2660 2670 2680 2690 2700
YDADPDALGR AYVREGGFLH DAAEFDAEFF GVSPREALAM DPQQRMLLTT
2710 2720 2730 2740 2750
SWEAFERAGI EPASLRGSST GVFIGLSYQD YAARVPNAPR GVEGYLLTGS
2760 2770 2780 2790 2800
TPSVASGRIA YTFGLEGPAT TVDTACSSSL TALHLAVRAL RSGECTMALA
2810 2820 2830 2840 2850
GGVAMMATPH MFVEFSRQRA LAPDGRSKAF SADADGFGAA EGVGLLLVER
2860 2870 2880 2890 2900
LSDARRNGHP VLAVVRGTAV NQDGASNGLT APNGPSQQRV IRQALADARL
2910 2920 2930 2940 2950
APGDIDAVET HGTGTSLGDP IEAQGLQATY GKERPAERPL AIGSVKSNIG
2960 2970 2980 2990 3000
HTQAAAGAAG IIKMVLAMRH GTLPKTLHAD EPSPHVDWAN SGLALVTEPI
3010 3020 3030 3040 3050
DWPAGTGPRR AAVSSFGISG TNAHVVLEQA PDAAGEVLGA DEVPEVSETV
3060 3070 3080 3090 3100
AMAGTAGTSE VAEGSEASEA PAAPGSREAS LPGHLPWVLS AKDEQSLRGQ
3110 3120 3130 3140 3150
AAALHAWLSE PAADLSDADG PARLRDVGYT LATSRTAFAH RAAVTAADRD
3160 3170 3180 3190 3200
GFLDGLATLA QGGTSAHVHL DTARDGTTAF LFTGQGSQRP GAGRELYDRH
3210 3220 3230 3240 3250
PVFARALDEI CAHLDGHLEL PLLDVMFAAE GSAEAALLDE TRYTQCALFA
3260 3270 3280 3290 3300
LEVALFRLVE SWGMRPAALL GHSVGEIAAA HVAGVFSLAD AARLVAARGR
3310 3320 3330 3340 3350
LMQELPAGGA MLAVQAAEDE IRVWLETEER YAGRLDVAAV NGPEAAVLSG
3360 3370 3380 3390 3400
DADAAREAEA YWSGLGRRTR ALRVSHAFHS AHMDGMLDGF RAVLETVEFR
3410 3420 3430 3440 3450
RPSLTVVSNV TGLAAGPDDL CDPEYWVRHV RGTVRFLDGV RVLRDLGVRT
3460 3470 3480 3490 3500
CLELGPDGVL TAMAADGLAD TPADSAAGSP VGSPAGSPAD SAAGALRPRP
3510 3520 3530 3540 3550
LLVALLRRKR SETETVADAL GRAHAHGTGP DWHAWFAGSG AHRVDLPTYS
3560 3570 3580 3590 3600
FRRDRYWLDA PAADTAVDTA GLGLGTADHP LLGAVVSLPD RDGLLLTGRL
3610 3620 3630 3640 3650
SLRTHPWLAD HAVLGSVLLP GAAMVELAAH AAESAGLRDV RELTLLEPLV
3660 3670 3680 3690 3700
LPEHGGVELR VTVGAPAGEP GGESAGDGAR PVSLHSRLAD APAGTAWSCH
3710 3720 3730 3740 3750
ATGLLATDRP ELPVAPDRAA MWPPQGAEEV PLDGLYERLD GNGLAFGPLF
3760 3770 3780 3790 3800
QGLNAVWRYE GEVFADIALP ATTNATAPAT ANGGGSAAAA PYGIHPALLD
3810 3820 3830 3840 3850
ASLHAIAVGG LVDEPELVRV PFHWSGVTVH AAGAAAARVR LASAGTDAVS
3860 3870 3880 3890 3900
LSLTDGEGRP LVSVERLTLR PVTADQAAAS RVGGLMHRVA WRPYALASSG
3910 3920 3930 3940 3950
EQDPHATSYG PTAVLGKDEL KVAAALESAG VEVGLYPDLA ALSQDVAAGA
3960 3970 3980 3990 4000
PAPRTVLAPL PAGPADGGAE GVRGTVARTL ELLQAWLADE HLAGTRLLLV
4010 4020 4030 4040 4050
TRGAVRDPEG SGADDGGEDL SHAAAWGLVR TAQTENPGRF GLLDLADDAS
4060 4070 4080 4090 4100
SYRTLPSVLS DAGLRDEPQL ALHDGTIRLA RLASVRPETG TAAPALAPEG
4110 4120 4130 4140 4150
TVLLTGGTGG LGGLVARHVV GEWGVRRLLL VSRRGTDAPG ADELVHELEA
4160 4170 4180 4190 4200
LGADVSVAAC DVADREALTA VLDAIPAEHP LTAVVHTAGV LSDGTLPSMT
4210 4220 4230 4240 4250
TEDVEHVLRP KVDAAFLLDE LTSTPAYDLA AFVMFSSAAA VFGGAGQGAY
4260 4270 4280 4290 4300
AAANATLDAL AWRRRAAGLP ALSLGWGLWA ETSGMTGELG QADLRRMSRA
4310 4320 4330 4340 4350
GIGGISDAEG IALLDAALRD DRHPVLLPLR LDAAGLRDAA GNDPAGIPAL
4360 4370 4380 4390 4400
FRDVVGARTV RARPSAASAS TTAGTAGTPG TADGAAETAA VTLADRAATV
4410 4420 4430 4440 4450
DGPARQRLLL EFVVGEVAEV LGHARGHRID AERGFLDLGF DSLTAVELRN
4460 4470 4480 4490 4500
RLNSAGGLAL PATLVFDHPS PAALASHLDA ELPRGASDQD GAGNRNGNEN
4510 4520 4530 4540 4550
GTTASRSTAE TDALLAQLTR LEGALVLTGL SDAPGSEEVL EHLRSLRSMV
4560 4570 4580 4590 4600
TGETGTGTAS GAPDGAGSGA EDRPWAAGDG AGGGSEDGAG VPDFMNASAE
4610
ELFGLLDQDP STD
Length:4,613
Mass (Da):477,293
Last modified:May 1, 1999 - v1
Checksum:iA3BAF8D37CEC9383
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69329.1.
PIRiT17409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69329.1 .
PIRi T17409.

3D structure databases

ProteinModelPortali Q9ZGI5.
SMRi Q9ZGI5. Positions 1108-1990, 4393-4482.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-18411.

Family and domain databases

Gene3Di 1.10.1200.10. 3 hits.
3.40.366.10. 7 hits.
3.40.47.10. 6 hits.
3.40.50.720. 3 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 3 hits.
PF00109. ketoacyl-synt. 3 hits.
PF02801. Ketoacyl-synt_C. 3 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 3 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 3 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 3 hits.
SM00823. PKS_PP. 3 hits.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 3 hits.
SSF52151. SSF52151. 6 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 3 hits.
PROSITEi PS50075. ACP_DOMAIN. 3 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
    Xue Y., Zhao L., Liu H.W., Sherman D.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC15439Imported.

Entry informationi

Entry nameiQ9ZGI5_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGI5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)