Q9ZGI5 (Q9ZGI5_STRVZ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Type I polyketide synthase PikAI EMBL AAC69329.1

Gene names

Name:

pikAI EMBL AAC69329.1

Organism

Streptomyces venezuelae EMBL AAC69329.1

Taxonomic identifier

54571 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	4613 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Molecular_function	phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9ZGI5 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: A3BAF8D37CEC9383	FASTA	4,613	477,293
	10 20 30 40 50 60 MSSAGITRTG ARTPVTGRGA AAWDTGEVRV RRGLPPAGPD HAEHSFSRAP TGDVRAELIR 70 80 90 100 110 120 GEMSTVSKSE SEEFVSVSND AGSAHGTAEP VAVVGISCRV PGARDPREFW ELLAAGGQAV 130 140 150 160 170 180 TDVPADRWNA GDFYDPDRSA PGRSNSRWGG FIEDVDRFDA AFFGISPREA AEMDPQQRLA 190 200 210 220 230 240 LELGWEALER AGIDPSSLTG TRTGVFAGAI WDDYATLKHR QGGAAITPHT VTGLHRGIIA 250 260 270 280 290 300 NRLSYTLGLR GPSMVVDSGQ SSSLVAVHLA CESLRRGESE LALAGGVSLN LVPDSIIGAS 310 320 330 340 350 360 KFGGLSPDGR AYTFDARANG YVRGEGGGFV VLKRLSRAVA DGDPVLAVIR GSAVNNGGAA 370 380 390 400 410 420 QGMTTPDAQA QEAVLREAHE RAGTAPADVR YVELHGTGTP VGDPIEAAAL GAALGTGRPA 430 440 450 460 470 480 GQPLLVGSVK TNIGHLEGAA GIAGLIKAVL AVRGRALPAS LNYETPNPAI PFEELNLRVN 490 500 510 520 530 540 TEYLPWEPEH DGQRMVVGVS SFGMGGTNAH VVLEEAPGGC RGASVVESTV GGSAVGGGVV 550 560 570 580 590 600 PWVVSAKSAA ALDAQIERLA AFASRDRTDG VDAGAVDAGA VDAGAVARVL AGGRAQFEHR 610 620 630 640 650 660 AVVVGSGPDD LAAALAAPEG LVRGVASGVG RVAFVFPGQG TQWAGMGAEL LDSSAVFAAA 670 680 690 700 710 720 MAECEAALSP YVDWSLEAVV RQAPGAPTLE RVDVVQPVTF AVMVSLARVW QHHGVTPQAV 730 740 750 760 770 780 VGHSQGEIAA AYVAGALSLD DAARVVTLRS KSIAAHLAGK GGMLSLALSE DAVLERLAGF 790 800 810 820 830 840 DGLSVAAVNG PTATVVSGDP VQIEELARAC EADGVRARVI PVDYASHSRQ VEIIESELAE 850 860 870 880 890 900 VLAGLSPQAP RVPFFSTLEG AWITEPVLDG GYWYRNLRHR VGFAPAVETL ATDEGFTHFV 910 920 930 940 950 960 EVSAHPVLTM ALPGTVTGLA TLRRDNGGQD RLVASLAEAW ANGLAVDWSP LLPSATGHHS 970 980 990 1000 1010 1020 DLPTYAFQTE RHWLGEIEAL APAGEPAVQP AVLRTEAAEP AELDRDEQLR VILDKVRAQT 1030 1040 1050 1060 1070 1080 AQVLGYATGG QIEVDRTFRE AGCTSLTGVD LRNRINAAFG VRMAPSMIFD FPTPEALAEQ 1090 1100 1110 1120 1130 1140 LLLVVHGEAA ANPAGAEPAP VAAAGAVDEP VAIVGMACRL PGGVASPEDL WRLVAGGGDA 1150 1160 1170 1180 1190 1200 ISEFPQDRGW DVEGLYHPDP EHPGTSYVRQ GGFIENVAGF DAAFFGISPR EALAMDPQQR 1210 1220 1230 1240 1250 1260 LLLETSWEAV EDAGIDPTSL RGRQVGVFTG AMTHEYGPSL RDGGEGLDGY LLTGNTASVM 1270 1280 1290 1300 1310 1320 SGRVSYTLGL EGPALTVDTA CSSSLVALHL AVQALRKGEV DMALAGGVAV MPTPGMFVEF 1330 1340 1350 1360 1370 1380 SRQRGLAGDG RSKAFAASAD GTSWSEGVGV LLVERLSDAR RNGHQVLAVV RGSALNQDGA 1390 1400 1410 1420 1430 1440 SNGLTAPNGP SQQRVIRRAL ADARLTTSDV DVVEAHGTGT RLGDPIEAQA LIATYGQGRD 1450 1460 1470 1480 1490 1500 DEQPLRLGSL KSNIGHTQAA AGVSGVIKMV QAMRHGLLPK TLHVDEPSDQ IDWSAGAVEL 1510 1520 1530 1540 1550 1560 LTEAVDWPEK QDGGLRRAAV SSFGISGTNA HVVLEEAPVV VEGASVVEPS VGGSAVGGGV 1570 1580 1590 1600 1610 1620 TPWVVSAKSA AALDAQIERL AAFASRDRTD DADAGAVDAG AVAHVLADGR AQFEHRAVAL 1630 1640 1650 1660 1670 1680 GAGADDLVQA LADPDGLIRG TASGVGRVAF VFPGQGTQWA GMGAELLDSS AVFAAAMAEC 1690 1700 1710 1720 1730 1740 EAALSPYVDW SLEAVVRQAP GAPTLERVDV VQPVTFAVMV SLARVWQHHG VTPQAVVGHS 1750 1760 1770 1780 1790 1800 QGEIAAAYVA GALPLDDAAR VVTLRSKSIA AHLAGKGGML SLALNEDAVL ERLSDFDGLS 1810 1820 1830 1840 1850 1860 VAAVNGPTAT VVSGDPVQIE ELAQACKADG FRARIIPVDY ASHSRQVEII ESELAQVLAG 1870 1880 1890 1900 1910 1920 LSPQAPRVPF FSTLEGTWIT EPVLDGTYWY RNLRHRVGFA PAIETLAVDE GFTHFVEVSA 1930 1940 1950 1960 1970 1980 HPVLTMTLPE TVTGLGTLRR EQGGQERLVT SLAEAWVNGL PVAWTSLLPA TASRPGLPTY 1990 2000 2010 2020 2030 2040 AFQAERYWLE NTPAALATGD DWRYRIDWKR LPAAEGSERT GLSGRWLAVT PEDHSAQAAA 2050 2060 2070 2080 2090 2100 VLTALVDAGA KVEVLTAGAD DDREALAARL TALTTGDGFT GVVSLLDGLV PQVAWVQALG 2110 2120 2130 2140 2150 2160 DAGIKAPLWS VTQGAVSVGR LDTPADPDRA MLWGLGRVVA LEHPERWAGL VDLPAQPDAA 2170 2180 2190 2200 2210 2220 ALAHLVTALS GATGEDQIAI RTTGLHARRL ARAPLHGRRP TRDWQPHGTV LITGGTGALG 2230 2240 2250 2260 2270 2280 SHAARWMAHH GAEHLLLVSR SGEQAPGATQ LTAELTASGA RVTIAACDVA DPHAMRTLLD 2290 2300 2310 2320 2330 2340 AIPAETPLTA VVHTAGALDD GIVDTLTAEQ VRRAHRAKAV GASVLDELTR DLDLDAFVLF 2350 2360 2370 2380 2390 2400 SSVSSTLGIP GQGNYAPHNA YLDALAARRR ATGRSAVSVA WGPWDGGGMA AGDGVAERLR 2410 2420 2430 2440 2450 2460 NHGVPGMDPE LALAALESAL GRDETAITVA DIDWDRFYLA YSSGRPQPLV EELPEVRRII 2470 2480 2490 2500 2510 2520 DARDSATSGQ GGSSAQGANP LAERLAAAAP GERTEILLGL VRAQAAAVLR MRSPEDVAAD 2530 2540 2550 2560 2570 2580 RAFKDIGFDS LAGVELRNRL TRATGLQLPA TLVFDHPTPL ALVSLLRSEF LGDEETADAR 2590 2600 2610 2620 2630 2640 RSAALPATVG AGAGAGAGTD ADDDPIAIVA MSCRYPGDIR SPEDLWRMLS EGGEGITPFP 2650 2660 2670 2680 2690 2700 TDRGWDLDGL YDADPDALGR AYVREGGFLH DAAEFDAEFF GVSPREALAM DPQQRMLLTT 2710 2720 2730 2740 2750 2760 SWEAFERAGI EPASLRGSST GVFIGLSYQD YAARVPNAPR GVEGYLLTGS TPSVASGRIA 2770 2780 2790 2800 2810 2820 YTFGLEGPAT TVDTACSSSL TALHLAVRAL RSGECTMALA GGVAMMATPH MFVEFSRQRA 2830 2840 2850 2860 2870 2880 LAPDGRSKAF SADADGFGAA EGVGLLLVER LSDARRNGHP VLAVVRGTAV NQDGASNGLT 2890 2900 2910 2920 2930 2940 APNGPSQQRV IRQALADARL APGDIDAVET HGTGTSLGDP IEAQGLQATY GKERPAERPL 2950 2960 2970 2980 2990 3000 AIGSVKSNIG HTQAAAGAAG IIKMVLAMRH GTLPKTLHAD EPSPHVDWAN SGLALVTEPI 3010 3020 3030 3040 3050 3060 DWPAGTGPRR AAVSSFGISG TNAHVVLEQA PDAAGEVLGA DEVPEVSETV AMAGTAGTSE 3070 3080 3090 3100 3110 3120 VAEGSEASEA PAAPGSREAS LPGHLPWVLS AKDEQSLRGQ AAALHAWLSE PAADLSDADG 3130 3140 3150 3160 3170 3180 PARLRDVGYT LATSRTAFAH RAAVTAADRD GFLDGLATLA QGGTSAHVHL DTARDGTTAF 3190 3200 3210 3220 3230 3240 LFTGQGSQRP GAGRELYDRH PVFARALDEI CAHLDGHLEL PLLDVMFAAE GSAEAALLDE 3250 3260 3270 3280 3290 3300 TRYTQCALFA LEVALFRLVE SWGMRPAALL GHSVGEIAAA HVAGVFSLAD AARLVAARGR 3310 3320 3330 3340 3350 3360 LMQELPAGGA MLAVQAAEDE IRVWLETEER YAGRLDVAAV NGPEAAVLSG DADAAREAEA 3370 3380 3390 3400 3410 3420 YWSGLGRRTR ALRVSHAFHS AHMDGMLDGF RAVLETVEFR RPSLTVVSNV TGLAAGPDDL 3430 3440 3450 3460 3470 3480 CDPEYWVRHV RGTVRFLDGV RVLRDLGVRT CLELGPDGVL TAMAADGLAD TPADSAAGSP 3490 3500 3510 3520 3530 3540 VGSPAGSPAD SAAGALRPRP LLVALLRRKR SETETVADAL GRAHAHGTGP DWHAWFAGSG 3550 3560 3570 3580 3590 3600 AHRVDLPTYS FRRDRYWLDA PAADTAVDTA GLGLGTADHP LLGAVVSLPD RDGLLLTGRL 3610 3620 3630 3640 3650 3660 SLRTHPWLAD HAVLGSVLLP GAAMVELAAH AAESAGLRDV RELTLLEPLV LPEHGGVELR 3670 3680 3690 3700 3710 3720 VTVGAPAGEP GGESAGDGAR PVSLHSRLAD APAGTAWSCH ATGLLATDRP ELPVAPDRAA 3730 3740 3750 3760 3770 3780 MWPPQGAEEV PLDGLYERLD GNGLAFGPLF QGLNAVWRYE GEVFADIALP ATTNATAPAT 3790 3800 3810 3820 3830 3840 ANGGGSAAAA PYGIHPALLD ASLHAIAVGG LVDEPELVRV PFHWSGVTVH AAGAAAARVR 3850 3860 3870 3880 3890 3900 LASAGTDAVS LSLTDGEGRP LVSVERLTLR PVTADQAAAS RVGGLMHRVA WRPYALASSG 3910 3920 3930 3940 3950 3960 EQDPHATSYG PTAVLGKDEL KVAAALESAG VEVGLYPDLA ALSQDVAAGA PAPRTVLAPL 3970 3980 3990 4000 4010 4020 PAGPADGGAE GVRGTVARTL ELLQAWLADE HLAGTRLLLV TRGAVRDPEG SGADDGGEDL 4030 4040 4050 4060 4070 4080 SHAAAWGLVR TAQTENPGRF GLLDLADDAS SYRTLPSVLS DAGLRDEPQL ALHDGTIRLA 4090 4100 4110 4120 4130 4140 RLASVRPETG TAAPALAPEG TVLLTGGTGG LGGLVARHVV GEWGVRRLLL VSRRGTDAPG 4150 4160 4170 4180 4190 4200 ADELVHELEA LGADVSVAAC DVADREALTA VLDAIPAEHP LTAVVHTAGV LSDGTLPSMT 4210 4220 4230 4240 4250 4260 TEDVEHVLRP KVDAAFLLDE LTSTPAYDLA AFVMFSSAAA VFGGAGQGAY AAANATLDAL 4270 4280 4290 4300 4310 4320 AWRRRAAGLP ALSLGWGLWA ETSGMTGELG QADLRRMSRA GIGGISDAEG IALLDAALRD 4330 4340 4350 4360 4370 4380 DRHPVLLPLR LDAAGLRDAA GNDPAGIPAL FRDVVGARTV RARPSAASAS TTAGTAGTPG 4390 4400 4410 4420 4430 4440 TADGAAETAA VTLADRAATV DGPARQRLLL EFVVGEVAEV LGHARGHRID AERGFLDLGF 4450 4460 4470 4480 4490 4500 DSLTAVELRN RLNSAGGLAL PATLVFDHPS PAALASHLDA ELPRGASDQD GAGNRNGNEN 4510 4520 4530 4540 4550 4560 GTTASRSTAE TDALLAQLTR LEGALVLTGL SDAPGSEEVL EHLRSLRSMV TGETGTGTAS 4570 4580 4590 4600 4610 GAPDGAGSGA EDRPWAAGDG AGGGSEDGAG VPDFMNASAE ELFGLLDQDP STD

References

[1]

"A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity." Xue Y., Zhao L., Liu H.W., Sherman D.H. Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC15439 EMBL AAC69329.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF079138 Genomic DNA. Translation: AAC69329.1.
PIR	T17409.
3D structure databases
ProteinModelPortal	Q9ZGI5.
SMR	Q9ZGI5. Positions 1108-1990, 4393-4482.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1200.10. 3 hits. 3.40.366.10. 7 hits. 3.40.47.10. 6 hits. 3.40.50.720. 3 hits.
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 3 hits. PF00109. ketoacyl-synt. 3 hits. PF02801. Ketoacyl-synt_C. 3 hits. PF08659. KR. 2 hits. PF00550. PP-binding. 3 hits. [Graphical view]
SMART	SM00827. PKS_AT. 3 hits. SM00826. PKS_DH. 1 hit. SM00822. PKS_KR. 2 hits. SM00825. PKS_KS. 3 hits. SM00823. PKS_PP. 3 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 3 hits. SSF52151. Acyl_Trfase/lysoPlipase. 3 hits. SSF55048. Malonyl_transacylase_ACP-bd. 3 hits. SSF53901. Thiolase-like. 3 hits.
PROSITE	PS50075. ACP_DOMAIN. 3 hits. PS00606. B_KETOACYL_SYNTHASE. 2 hits. PS00012. PHOSPHOPANTETHEINE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9ZGI5_STRVZ

Accession

Primary (citable) accession number: Q9ZGI5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)