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Q9ZGI4

- Q9ZGI4_STRVZ

UniProt

Q9ZGI4 - Q9ZGI4_STRVZ

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Protein
Submitted name:

Type I polyketide synthase PikAII

Gene

pikAII

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
  3. phosphopantetheine binding Source: InterPro
  4. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro
  5. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18412.

Names & Taxonomyi

Protein namesi
Submitted name:
Type I polyketide synthase PikAIIImported
Gene namesi
Name:pikAIIImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QP9X-ray1.88A/B/C/D920-1423[»]
ProteinModelPortaliQ9ZGI4.
SMRiQ9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 4 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 2 hits.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZGI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVNEEKYL DYLRRATADL HEARGRLREL EAKAGEPVAI VGMACRLPGG
60 70 80 90 100
VASPEDLWRL VAGGEDAISE FPQDRGWDVE GLYDPNPEAT GKSYAREAGF
110 120 130 140 150
LYEAGEFDAD FFGISPREAL AMDPQQRLLL EASWEAFEHA GIPAATARGT
160 170 180 190 200
SVGVFTGVMY HDYATRLTDV PEGIEGYLGT GNSGSVASGR VAYTLGLEGP
210 220 230 240 250
AVTVDTACSS SLVALHLAVQ ALRKGEVDMA LAGGVTVMST PSTFVEFSRQ
260 270 280 290 300
RGLAPDGRSK SFSSTADGTS WSEGVGVLLV ERLSDARRKG HRILAVVRGT
310 320 330 340 350
AVNQDGASSG LTAPNGPSQQ RVIRRALADA RLTTSDVDVV EAHGTGTRLG
360 370 380 390 400
DPIEAQAVIA TYGQGRDGEQ PLRLGSLKSN IGHTQAAAGV SGVIKMVQAM
410 420 430 440 450
RHGVLPKTLH VEKPTDQVDW SAGAVELLTE AMDWPDKGDG GLRRAAVSSF
460 470 480 490 500
GVSGTNAHVV LEEAPAAEET PASEATPAVE PSVGAGLVPW LVSAKTPAAL
510 520 530 540 550
DAQIGRLAAF ASQGRTDAAD PGAVARVLAG GRAEFEHRAV VLGTGQDDFA
560 570 580 590 600
QALTAPEGLI RGTPSDVGRV AFVFPGQGTQ WAGMGAELLD VSKEFAAAMA
610 620 630 640 650
ECESALSRYV DWSLEAVVRQ APGAPTLERV DVVQPVTFAV MVSLAKVWQH
660 670 680 690 700
HGVTPQAVVG HSQGEIAAAY VAGALTLDDA ARVVTLRSKS IAAHLAGKGG
710 720 730 740 750
MISLALSEEA TRQRIENLHG LSIAAVNGPT ATVVSGDPTQ IQELAQACEA
760 770 780 790 800
DGVRARIIPV DYASHSAHVE TIESELAEVL AGLSPRTPEV PFFSTLEGAW
810 820 830 840 850
ITEPVLDGTY WYRNLRHRVG FAPAVETLAT DEGFTHFIEV SAHPVLTMTL
860 870 880 890 900
PETVTGLGTL RREQGGQERL VTSLAEAWTN GLTIDWAPVL PTATGHHPEL
910 920 930 940 950
PTYAFQRRHY WLHDSPAVQG SVQDSWRYRI DWKRLAVADA SERAGLSGRW
960 970 980 990 1000
LVVVPEDRSA EAAPVLAALS GAGADPVQLD VSPLGDRQRL AATLGEALAA
1010 1020 1030 1040 1050
AGGAVDGVLS LLAWDESAHP GHPAPFTRGT GATLTLVQAL EDAGVAAPLW
1060 1070 1080 1090 1100
CVTHGAVSVG RADHVTSPAQ AMVWGMGRVA ALEHPERWGG LIDLPSDADR
1110 1120 1130 1140 1150
AALDRMTTVL AGGTGEDQVA VRASGLLARR LVRASLPAHG TASPWWQADG
1160 1170 1180 1190 1200
TVLVTGAEEP AAAEAARRLA RDGAGHLLLH TTPSGSEGAE GTSGAAEDSG
1210 1220 1230 1240 1250
LAGLVAELAD LGATATVVTC DLTDAEAAAR LLAGVSDAHP LSAVLHLPPT
1260 1270 1280 1290 1300
VDSEPLAATD ADALARVVTA KATAALHLDR LLREAAAAGG RPPVLVLFSS
1310 1320 1330 1340 1350
VAAIWGGAGQ GAYAAGTAFL DALAGQHRAD GPTVTSVAWS PWEGSRVTEG
1360 1370 1380 1390 1400
ATGERLRRLG LRPLAPATAL TALDTALGHG DTAVTIADVD WSSFAPGFTT
1410 1420 1430 1440 1450
ARPGTLLADL PEARRALDEQ QSTTAADDTV LSRELGALTG AEQQRRMQEL
1460 1470 1480 1490 1500
VREHLAVVLN HPSPEAVDTG RAFRDLGFDS LTAVELRNRL KNATGLALPA
1510 1520 1530 1540 1550
TLVFDYPTPR TLAEFLLAEI LGEQAGAGEQ LPVDGGVDDE PVAIVGMACR
1560 1570 1580 1590 1600
LPGGVASPED LWRLVAGGED AISGFPQDRG WDVEGLYDPD PDASGRTYCR
1610 1620 1630 1640 1650
AGGFLDEAGE FDADFFGISP REALAMDPQQ RLLLETSWEA VEDAGIDPTS
1660 1670 1680 1690 1700
LQGQQVGVFA GTNGPHYEPL LRNTAEDLEG YVGTGNAASI MSGRVSYTLG
1710 1720 1730 1740 1750
LEGPAVTVDT ACSSSLVALH LAVQALRKGE CGLALAGGVT VMSTPTTFVE
1760 1770 1780 1790 1800
FSRQRGLAED GRSKAFAASA DGFGPAEGVG MLLVERLSDA RRNGHRVLAV
1810 1820 1830 1840 1850
VRGSAVNQDG ASNGLTAPNG PSQQRVIRRA LADARLTTAD VDVVEAHGTG
1860 1870 1880 1890 1900
TRLGDPIEAQ ALIATYGQGR DTEQPLRLGS LKSNIGHTQA AAGVSGIIKM
1910 1920 1930 1940 1950
VQAMRHGVLP KTLHVDRPSD QIDWSAGTVE LLTEAMDWPR KQEGGLRRAA
1960 1970 1980 1990 2000
VSSFGISGTN AHIVLEEAPV DEDAPADEPS VGGVVPWLVS AKTPAALDAQ
2010 2020 2030 2040 2050
IGRLAAFASQ GRTDAADPGA VARVLAGGRA QFEHRAVALG TGQDDLAAAL
2060 2070 2080 2090 2100
AAPEGLVRGV ASGVGRVAFV FPGQGTQWAG MGAELLDVSK EFAAAMAECE
2110 2120 2130 2140 2150
AALAPYVDWS LEAVVRQAPG APTLERVDVV QPVTFAVMVS LAKVWQHHGV
2160 2170 2180 2190 2200
TPQAVVGHSQ GEIAAAYVAG ALSLDDAARV VTLRSKSIGA HLAGQGGMLS
2210 2220 2230 2240 2250
LALSEAAVVE RLAGFDGLSV AAVNGPTATV VSGDPTQIQE LAQACEADGV
2260 2270 2280 2290 2300
RARIIPVDYA SHSAHVETIE SELADVLAGL SPQTPQVPFF STLEGAWITE
2310 2320 2330 2340 2350
PALDGGYWYR NLRHRVGFAP AVETLATDEG FTHFVEVSAH PVLTMALPET
2360 2370 2380 2390 2400
VTGLGTLRRD NGGQHRLTTS LAEAWANGLT VDWASLLPTT TTHPDLPTYA
2410 2420 2430 2440 2450
FQTERYWPQP DLSAAGDITS AGLGAAEHPL LGAAVALADS DGCLLTGSLS
2460 2470 2480 2490 2500
LRTHPWLADH AVAGTVLLPG TAFVELAFRA GDQVGCDLVE ELTLDAPLVL
2510 2520 2530 2540 2550
PRRGAVRVQL SVGASDESGR RTFGLYAHPE DAPGEAEWTR HATGVLAARA
2560 2570 2580 2590 2600
DRTAPVADPE AWPPPGAEPV DVDGLYERFA ANGYGYGPLF QGVRGVWRRG
2610 2620 2630 2640 2650
DEVFADVALP AEVAGAEGAR FGLHPALLDA AVQAAGAGRG VRRGHAAAVR
2660 2670 2680 2690 2700
LERDLLYAVG ATALRVRLAP AGPDTVSVSA ADSSGQPVFA ADSLTVLPVD
2710 2720 2730 2740 2750
PAQLAAFSDP TLDALHLLEW TAWDGAAQAL PGAVVLGGDA DGLAAALRAG
2760 2770 2780 2790 2800
GTEVLSFPDL TDLVEAVDRG ETPAPATVLV ACPAAGPDGP EHVREALHGS
2810 2820 2830 2840 2850
LALMQAWLAD ERFTDGRLVL VTRDAVAARS GDGLRSTGQA AVWGLGRSAQ
2860 2870 2880 2890 2900
TESPGRFVLL DLAGEARTAG DATAGDGLTT GDATVGGTSG DAALGSALAT
2910 2920 2930 2940 2950
ALGSGEPQLA LRDGALLVPR LARAAAPAAA DGLAAADGLA ALPLPAAPAL
2960 2970 2980 2990 3000
WRLEPGTDGS LESLTAAPGD AETLAPEPLG PGQVRIAIRA TGLNFRDVLI
3010 3020 3030 3040 3050
ALGMYPDPAL MGTEGAGVVT ATGPGVTHLA PGDRVMGLLS GAYAPVVVAD
3060 3070 3080 3090 3100
ARTVARMPEG WTFAQGASVP VVFLTAVYAL RDLADVKPGE RLLVHSAAGG
3110 3120 3130 3140 3150
VGMAAVQLAR HWGVEVHGTA SHGKWDALRA LGLDDAHIAS SRTLDFESAF
3160 3170 3180 3190 3200
RAASGGAGMD VVLNSLAREF VDASLRLLGP GGRFVEMGKT DVRDAERVAA
3210 3220 3230 3240 3250
DHPGVGYRAF DLGEAGPERI GEMLAEVIAL FEDGVLRHLP VTTWDVRRAR
3260 3270 3280 3290 3300
DAFRHVSQAR HTGKVVLTMP SGLDPEGTVL LTGGTGALGG IVARHVVGEW
3310 3320 3330 3340 3350
GVRRLLLVSR RGTDAPGAGE LVHELEALGA DVSVAACDVA DREALTAVLD
3360 3370 3380 3390 3400
SIPAEHPLTA VVHTAGVLSD GTLPSMTAED VEHVLRPKVD AAFLLDELTS
3410 3420 3430 3440 3450
TPGYDLAAFV MFSSAAAVFG GAGQGAYAAA NATLDALAWR RRTAGLPALS
3460 3470 3480 3490 3500
LGWGLWAETS GMTGGLSDTD RSRLARSGAT PMDSELTLSL LDAAMRRDDP
3510 3520 3530 3540 3550
ALVPIALDVA ALRAQQRDGM LAPLLSGLTR GSRVGGAPVN QRRAAAGGAG
3560 3570 3580 3590 3600
EADTDLGGRL AAMTPDDRVA HLRDLVRTHV ATVLGHGTPS RVDLERAFRD
3610 3620 3630 3640 3650
TGFDSLTAVE LRNRLNAATG LRLPATLVFD HPTPGELAGH LLDELATAAG
3660 3670 3680 3690 3700
GSWAEGTGSG DTASATDRQT TAALAELDRL EGVLASLAPA AGGRPELAAR
3710 3720 3730
LRALAAALGD DGDDATDLDE ASDDDLFSFI DKELGDSDF
Length:3,739
Mass (Da):387,178
Last modified:May 1, 1999 - v1
Checksum:i3D3910824DA5B080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079138 Genomic DNA. Translation: AAC69330.1.
PIRiT17410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079138 Genomic DNA. Translation: AAC69330.1 .
PIRi T17410.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QP9 X-ray 1.88 A/B/C/D 920-1423 [» ]
ProteinModelPortali Q9ZGI4.
SMRi Q9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-18412.

Family and domain databases

Gene3Di 1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 4 hits.
3.90.180.10. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 2 hits.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 2 hits.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 2 hits.
PROSITEi PS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
    Xue Y., Zhao L., Liu H.W., Sherman D.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC15439Imported.
  2. "Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases."
    Zheng J., Keatinge-Clay A.T.
    J. Mol. Biol. 410:105-117(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 920-1423.

Entry informationi

Entry nameiQ9ZGI4_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGI4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3