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Q9ZGI4

- Q9ZGI4_STRVZ

UniProt

Q9ZGI4 - Q9ZGI4_STRVZ

Protein
Submitted name:

Type I polyketide synthase PikAII

Gene

pikAII

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cofactor binding Source: InterPro
    2. oxidoreductase activity Source: InterPro
    3. phosphopantetheine binding Source: InterPro
    4. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro
    5. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18412.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Type I polyketide synthase PikAIIImported
    Gene namesi
    Name:pikAIIImported
    OrganismiStreptomyces venezuelaeImported
    Taxonomic identifieri54571 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3QP9X-ray1.88A/B/C/D920-1423[»]
    ProteinModelPortaliQ9ZGI4.
    SMRiQ9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.10. 2 hits.
    3.40.366.10. 4 hits.
    3.40.47.10. 4 hits.
    3.40.50.720. 4 hits.
    3.90.180.10. 1 hit.
    InterProiIPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR011032. GroES-like.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR020843. PKS_ER.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 2 hits.
    PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 2 hits.
    PF02801. Ketoacyl-synt_C. 2 hits.
    PF08659. KR. 2 hits.
    PF00550. PP-binding. 2 hits.
    [Graphical view]
    SMARTiSM00827. PKS_AT. 2 hits.
    SM00826. PKS_DH. 1 hit.
    SM00829. PKS_ER. 1 hit.
    SM00822. PKS_KR. 2 hits.
    SM00825. PKS_KS. 2 hits.
    SM00823. PKS_PP. 2 hits.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 2 hits.
    SSF50129. SSF50129. 1 hit.
    SSF52151. SSF52151. 4 hits.
    SSF53901. SSF53901. 4 hits.
    SSF55048. SSF55048. 2 hits.
    PROSITEiPS50075. ACP_DOMAIN. 2 hits.
    PS00606. B_KETOACYL_SYNTHASE. 2 hits.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    PS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZGI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVNEEKYL DYLRRATADL HEARGRLREL EAKAGEPVAI VGMACRLPGG     50
    VASPEDLWRL VAGGEDAISE FPQDRGWDVE GLYDPNPEAT GKSYAREAGF 100
    LYEAGEFDAD FFGISPREAL AMDPQQRLLL EASWEAFEHA GIPAATARGT 150
    SVGVFTGVMY HDYATRLTDV PEGIEGYLGT GNSGSVASGR VAYTLGLEGP 200
    AVTVDTACSS SLVALHLAVQ ALRKGEVDMA LAGGVTVMST PSTFVEFSRQ 250
    RGLAPDGRSK SFSSTADGTS WSEGVGVLLV ERLSDARRKG HRILAVVRGT 300
    AVNQDGASSG LTAPNGPSQQ RVIRRALADA RLTTSDVDVV EAHGTGTRLG 350
    DPIEAQAVIA TYGQGRDGEQ PLRLGSLKSN IGHTQAAAGV SGVIKMVQAM 400
    RHGVLPKTLH VEKPTDQVDW SAGAVELLTE AMDWPDKGDG GLRRAAVSSF 450
    GVSGTNAHVV LEEAPAAEET PASEATPAVE PSVGAGLVPW LVSAKTPAAL 500
    DAQIGRLAAF ASQGRTDAAD PGAVARVLAG GRAEFEHRAV VLGTGQDDFA 550
    QALTAPEGLI RGTPSDVGRV AFVFPGQGTQ WAGMGAELLD VSKEFAAAMA 600
    ECESALSRYV DWSLEAVVRQ APGAPTLERV DVVQPVTFAV MVSLAKVWQH 650
    HGVTPQAVVG HSQGEIAAAY VAGALTLDDA ARVVTLRSKS IAAHLAGKGG 700
    MISLALSEEA TRQRIENLHG LSIAAVNGPT ATVVSGDPTQ IQELAQACEA 750
    DGVRARIIPV DYASHSAHVE TIESELAEVL AGLSPRTPEV PFFSTLEGAW 800
    ITEPVLDGTY WYRNLRHRVG FAPAVETLAT DEGFTHFIEV SAHPVLTMTL 850
    PETVTGLGTL RREQGGQERL VTSLAEAWTN GLTIDWAPVL PTATGHHPEL 900
    PTYAFQRRHY WLHDSPAVQG SVQDSWRYRI DWKRLAVADA SERAGLSGRW 950
    LVVVPEDRSA EAAPVLAALS GAGADPVQLD VSPLGDRQRL AATLGEALAA 1000
    AGGAVDGVLS LLAWDESAHP GHPAPFTRGT GATLTLVQAL EDAGVAAPLW 1050
    CVTHGAVSVG RADHVTSPAQ AMVWGMGRVA ALEHPERWGG LIDLPSDADR 1100
    AALDRMTTVL AGGTGEDQVA VRASGLLARR LVRASLPAHG TASPWWQADG 1150
    TVLVTGAEEP AAAEAARRLA RDGAGHLLLH TTPSGSEGAE GTSGAAEDSG 1200
    LAGLVAELAD LGATATVVTC DLTDAEAAAR LLAGVSDAHP LSAVLHLPPT 1250
    VDSEPLAATD ADALARVVTA KATAALHLDR LLREAAAAGG RPPVLVLFSS 1300
    VAAIWGGAGQ GAYAAGTAFL DALAGQHRAD GPTVTSVAWS PWEGSRVTEG 1350
    ATGERLRRLG LRPLAPATAL TALDTALGHG DTAVTIADVD WSSFAPGFTT 1400
    ARPGTLLADL PEARRALDEQ QSTTAADDTV LSRELGALTG AEQQRRMQEL 1450
    VREHLAVVLN HPSPEAVDTG RAFRDLGFDS LTAVELRNRL KNATGLALPA 1500
    TLVFDYPTPR TLAEFLLAEI LGEQAGAGEQ LPVDGGVDDE PVAIVGMACR 1550
    LPGGVASPED LWRLVAGGED AISGFPQDRG WDVEGLYDPD PDASGRTYCR 1600
    AGGFLDEAGE FDADFFGISP REALAMDPQQ RLLLETSWEA VEDAGIDPTS 1650
    LQGQQVGVFA GTNGPHYEPL LRNTAEDLEG YVGTGNAASI MSGRVSYTLG 1700
    LEGPAVTVDT ACSSSLVALH LAVQALRKGE CGLALAGGVT VMSTPTTFVE 1750
    FSRQRGLAED GRSKAFAASA DGFGPAEGVG MLLVERLSDA RRNGHRVLAV 1800
    VRGSAVNQDG ASNGLTAPNG PSQQRVIRRA LADARLTTAD VDVVEAHGTG 1850
    TRLGDPIEAQ ALIATYGQGR DTEQPLRLGS LKSNIGHTQA AAGVSGIIKM 1900
    VQAMRHGVLP KTLHVDRPSD QIDWSAGTVE LLTEAMDWPR KQEGGLRRAA 1950
    VSSFGISGTN AHIVLEEAPV DEDAPADEPS VGGVVPWLVS AKTPAALDAQ 2000
    IGRLAAFASQ GRTDAADPGA VARVLAGGRA QFEHRAVALG TGQDDLAAAL 2050
    AAPEGLVRGV ASGVGRVAFV FPGQGTQWAG MGAELLDVSK EFAAAMAECE 2100
    AALAPYVDWS LEAVVRQAPG APTLERVDVV QPVTFAVMVS LAKVWQHHGV 2150
    TPQAVVGHSQ GEIAAAYVAG ALSLDDAARV VTLRSKSIGA HLAGQGGMLS 2200
    LALSEAAVVE RLAGFDGLSV AAVNGPTATV VSGDPTQIQE LAQACEADGV 2250
    RARIIPVDYA SHSAHVETIE SELADVLAGL SPQTPQVPFF STLEGAWITE 2300
    PALDGGYWYR NLRHRVGFAP AVETLATDEG FTHFVEVSAH PVLTMALPET 2350
    VTGLGTLRRD NGGQHRLTTS LAEAWANGLT VDWASLLPTT TTHPDLPTYA 2400
    FQTERYWPQP DLSAAGDITS AGLGAAEHPL LGAAVALADS DGCLLTGSLS 2450
    LRTHPWLADH AVAGTVLLPG TAFVELAFRA GDQVGCDLVE ELTLDAPLVL 2500
    PRRGAVRVQL SVGASDESGR RTFGLYAHPE DAPGEAEWTR HATGVLAARA 2550
    DRTAPVADPE AWPPPGAEPV DVDGLYERFA ANGYGYGPLF QGVRGVWRRG 2600
    DEVFADVALP AEVAGAEGAR FGLHPALLDA AVQAAGAGRG VRRGHAAAVR 2650
    LERDLLYAVG ATALRVRLAP AGPDTVSVSA ADSSGQPVFA ADSLTVLPVD 2700
    PAQLAAFSDP TLDALHLLEW TAWDGAAQAL PGAVVLGGDA DGLAAALRAG 2750
    GTEVLSFPDL TDLVEAVDRG ETPAPATVLV ACPAAGPDGP EHVREALHGS 2800
    LALMQAWLAD ERFTDGRLVL VTRDAVAARS GDGLRSTGQA AVWGLGRSAQ 2850
    TESPGRFVLL DLAGEARTAG DATAGDGLTT GDATVGGTSG DAALGSALAT 2900
    ALGSGEPQLA LRDGALLVPR LARAAAPAAA DGLAAADGLA ALPLPAAPAL 2950
    WRLEPGTDGS LESLTAAPGD AETLAPEPLG PGQVRIAIRA TGLNFRDVLI 3000
    ALGMYPDPAL MGTEGAGVVT ATGPGVTHLA PGDRVMGLLS GAYAPVVVAD 3050
    ARTVARMPEG WTFAQGASVP VVFLTAVYAL RDLADVKPGE RLLVHSAAGG 3100
    VGMAAVQLAR HWGVEVHGTA SHGKWDALRA LGLDDAHIAS SRTLDFESAF 3150
    RAASGGAGMD VVLNSLAREF VDASLRLLGP GGRFVEMGKT DVRDAERVAA 3200
    DHPGVGYRAF DLGEAGPERI GEMLAEVIAL FEDGVLRHLP VTTWDVRRAR 3250
    DAFRHVSQAR HTGKVVLTMP SGLDPEGTVL LTGGTGALGG IVARHVVGEW 3300
    GVRRLLLVSR RGTDAPGAGE LVHELEALGA DVSVAACDVA DREALTAVLD 3350
    SIPAEHPLTA VVHTAGVLSD GTLPSMTAED VEHVLRPKVD AAFLLDELTS 3400
    TPGYDLAAFV MFSSAAAVFG GAGQGAYAAA NATLDALAWR RRTAGLPALS 3450
    LGWGLWAETS GMTGGLSDTD RSRLARSGAT PMDSELTLSL LDAAMRRDDP 3500
    ALVPIALDVA ALRAQQRDGM LAPLLSGLTR GSRVGGAPVN QRRAAAGGAG 3550
    EADTDLGGRL AAMTPDDRVA HLRDLVRTHV ATVLGHGTPS RVDLERAFRD 3600
    TGFDSLTAVE LRNRLNAATG LRLPATLVFD HPTPGELAGH LLDELATAAG 3650
    GSWAEGTGSG DTASATDRQT TAALAELDRL EGVLASLAPA AGGRPELAAR 3700
    LRALAAALGD DGDDATDLDE ASDDDLFSFI DKELGDSDF 3739
    Length:3,739
    Mass (Da):387,178
    Last modified:May 1, 1999 - v1
    Checksum:i3D3910824DA5B080
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69330.1.
    PIRiT17410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69330.1 .
    PIRi T17410.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3QP9 X-ray 1.88 A/B/C/D 920-1423 [» ]
    ProteinModelPortali Q9ZGI4.
    SMRi Q9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-18412.

    Family and domain databases

    Gene3Di 1.10.1200.10. 2 hits.
    3.40.366.10. 4 hits.
    3.40.47.10. 4 hits.
    3.40.50.720. 4 hits.
    3.90.180.10. 1 hit.
    InterProi IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR011032. GroES-like.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR020843. PKS_ER.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 2 hits.
    PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 2 hits.
    PF02801. Ketoacyl-synt_C. 2 hits.
    PF08659. KR. 2 hits.
    PF00550. PP-binding. 2 hits.
    [Graphical view ]
    SMARTi SM00827. PKS_AT. 2 hits.
    SM00826. PKS_DH. 1 hit.
    SM00829. PKS_ER. 1 hit.
    SM00822. PKS_KR. 2 hits.
    SM00825. PKS_KS. 2 hits.
    SM00823. PKS_PP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 2 hits.
    SSF50129. SSF50129. 1 hit.
    SSF52151. SSF52151. 4 hits.
    SSF53901. SSF53901. 4 hits.
    SSF55048. SSF55048. 2 hits.
    PROSITEi PS50075. ACP_DOMAIN. 2 hits.
    PS00606. B_KETOACYL_SYNTHASE. 2 hits.
    PS00012. PHOSPHOPANTETHEINE. 2 hits.
    PS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
      Xue Y., Zhao L., Liu H.W., Sherman D.H.
      Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15439Imported.
    2. "Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases."
      Zheng J., Keatinge-Clay A.T.
      J. Mol. Biol. 410:105-117(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 920-1423.

    Entry informationi

    Entry nameiQ9ZGI4_STRVZ
    AccessioniPrimary (citable) accession number: Q9ZGI4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3