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Q9ZGI4

- Q9ZGI4_STRVZ

UniProt

Q9ZGI4 - Q9ZGI4_STRVZ

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Protein
Submitted name:

Type I polyketide synthase PikAII

Gene
pikAII
Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
  3. phosphopantetheine binding Source: InterPro
  4. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro
  5. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18412.

Names & Taxonomyi

Protein namesi
Submitted name:
Type I polyketide synthase PikAIIImported
Gene namesi
Name:pikAIIImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QP9X-ray1.88A/B/C/D920-1423[»]
ProteinModelPortaliQ9ZGI4.
SMRiQ9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 4 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 2 hits.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 2 hits.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZGI4-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVNEEKYL DYLRRATADL HEARGRLREL EAKAGEPVAI VGMACRLPGG     50
VASPEDLWRL VAGGEDAISE FPQDRGWDVE GLYDPNPEAT GKSYAREAGF 100
LYEAGEFDAD FFGISPREAL AMDPQQRLLL EASWEAFEHA GIPAATARGT 150
SVGVFTGVMY HDYATRLTDV PEGIEGYLGT GNSGSVASGR VAYTLGLEGP 200
AVTVDTACSS SLVALHLAVQ ALRKGEVDMA LAGGVTVMST PSTFVEFSRQ 250
RGLAPDGRSK SFSSTADGTS WSEGVGVLLV ERLSDARRKG HRILAVVRGT 300
AVNQDGASSG LTAPNGPSQQ RVIRRALADA RLTTSDVDVV EAHGTGTRLG 350
DPIEAQAVIA TYGQGRDGEQ PLRLGSLKSN IGHTQAAAGV SGVIKMVQAM 400
RHGVLPKTLH VEKPTDQVDW SAGAVELLTE AMDWPDKGDG GLRRAAVSSF 450
GVSGTNAHVV LEEAPAAEET PASEATPAVE PSVGAGLVPW LVSAKTPAAL 500
DAQIGRLAAF ASQGRTDAAD PGAVARVLAG GRAEFEHRAV VLGTGQDDFA 550
QALTAPEGLI RGTPSDVGRV AFVFPGQGTQ WAGMGAELLD VSKEFAAAMA 600
ECESALSRYV DWSLEAVVRQ APGAPTLERV DVVQPVTFAV MVSLAKVWQH 650
HGVTPQAVVG HSQGEIAAAY VAGALTLDDA ARVVTLRSKS IAAHLAGKGG 700
MISLALSEEA TRQRIENLHG LSIAAVNGPT ATVVSGDPTQ IQELAQACEA 750
DGVRARIIPV DYASHSAHVE TIESELAEVL AGLSPRTPEV PFFSTLEGAW 800
ITEPVLDGTY WYRNLRHRVG FAPAVETLAT DEGFTHFIEV SAHPVLTMTL 850
PETVTGLGTL RREQGGQERL VTSLAEAWTN GLTIDWAPVL PTATGHHPEL 900
PTYAFQRRHY WLHDSPAVQG SVQDSWRYRI DWKRLAVADA SERAGLSGRW 950
LVVVPEDRSA EAAPVLAALS GAGADPVQLD VSPLGDRQRL AATLGEALAA 1000
AGGAVDGVLS LLAWDESAHP GHPAPFTRGT GATLTLVQAL EDAGVAAPLW 1050
CVTHGAVSVG RADHVTSPAQ AMVWGMGRVA ALEHPERWGG LIDLPSDADR 1100
AALDRMTTVL AGGTGEDQVA VRASGLLARR LVRASLPAHG TASPWWQADG 1150
TVLVTGAEEP AAAEAARRLA RDGAGHLLLH TTPSGSEGAE GTSGAAEDSG 1200
LAGLVAELAD LGATATVVTC DLTDAEAAAR LLAGVSDAHP LSAVLHLPPT 1250
VDSEPLAATD ADALARVVTA KATAALHLDR LLREAAAAGG RPPVLVLFSS 1300
VAAIWGGAGQ GAYAAGTAFL DALAGQHRAD GPTVTSVAWS PWEGSRVTEG 1350
ATGERLRRLG LRPLAPATAL TALDTALGHG DTAVTIADVD WSSFAPGFTT 1400
ARPGTLLADL PEARRALDEQ QSTTAADDTV LSRELGALTG AEQQRRMQEL 1450
VREHLAVVLN HPSPEAVDTG RAFRDLGFDS LTAVELRNRL KNATGLALPA 1500
TLVFDYPTPR TLAEFLLAEI LGEQAGAGEQ LPVDGGVDDE PVAIVGMACR 1550
LPGGVASPED LWRLVAGGED AISGFPQDRG WDVEGLYDPD PDASGRTYCR 1600
AGGFLDEAGE FDADFFGISP REALAMDPQQ RLLLETSWEA VEDAGIDPTS 1650
LQGQQVGVFA GTNGPHYEPL LRNTAEDLEG YVGTGNAASI MSGRVSYTLG 1700
LEGPAVTVDT ACSSSLVALH LAVQALRKGE CGLALAGGVT VMSTPTTFVE 1750
FSRQRGLAED GRSKAFAASA DGFGPAEGVG MLLVERLSDA RRNGHRVLAV 1800
VRGSAVNQDG ASNGLTAPNG PSQQRVIRRA LADARLTTAD VDVVEAHGTG 1850
TRLGDPIEAQ ALIATYGQGR DTEQPLRLGS LKSNIGHTQA AAGVSGIIKM 1900
VQAMRHGVLP KTLHVDRPSD QIDWSAGTVE LLTEAMDWPR KQEGGLRRAA 1950
VSSFGISGTN AHIVLEEAPV DEDAPADEPS VGGVVPWLVS AKTPAALDAQ 2000
IGRLAAFASQ GRTDAADPGA VARVLAGGRA QFEHRAVALG TGQDDLAAAL 2050
AAPEGLVRGV ASGVGRVAFV FPGQGTQWAG MGAELLDVSK EFAAAMAECE 2100
AALAPYVDWS LEAVVRQAPG APTLERVDVV QPVTFAVMVS LAKVWQHHGV 2150
TPQAVVGHSQ GEIAAAYVAG ALSLDDAARV VTLRSKSIGA HLAGQGGMLS 2200
LALSEAAVVE RLAGFDGLSV AAVNGPTATV VSGDPTQIQE LAQACEADGV 2250
RARIIPVDYA SHSAHVETIE SELADVLAGL SPQTPQVPFF STLEGAWITE 2300
PALDGGYWYR NLRHRVGFAP AVETLATDEG FTHFVEVSAH PVLTMALPET 2350
VTGLGTLRRD NGGQHRLTTS LAEAWANGLT VDWASLLPTT TTHPDLPTYA 2400
FQTERYWPQP DLSAAGDITS AGLGAAEHPL LGAAVALADS DGCLLTGSLS 2450
LRTHPWLADH AVAGTVLLPG TAFVELAFRA GDQVGCDLVE ELTLDAPLVL 2500
PRRGAVRVQL SVGASDESGR RTFGLYAHPE DAPGEAEWTR HATGVLAARA 2550
DRTAPVADPE AWPPPGAEPV DVDGLYERFA ANGYGYGPLF QGVRGVWRRG 2600
DEVFADVALP AEVAGAEGAR FGLHPALLDA AVQAAGAGRG VRRGHAAAVR 2650
LERDLLYAVG ATALRVRLAP AGPDTVSVSA ADSSGQPVFA ADSLTVLPVD 2700
PAQLAAFSDP TLDALHLLEW TAWDGAAQAL PGAVVLGGDA DGLAAALRAG 2750
GTEVLSFPDL TDLVEAVDRG ETPAPATVLV ACPAAGPDGP EHVREALHGS 2800
LALMQAWLAD ERFTDGRLVL VTRDAVAARS GDGLRSTGQA AVWGLGRSAQ 2850
TESPGRFVLL DLAGEARTAG DATAGDGLTT GDATVGGTSG DAALGSALAT 2900
ALGSGEPQLA LRDGALLVPR LARAAAPAAA DGLAAADGLA ALPLPAAPAL 2950
WRLEPGTDGS LESLTAAPGD AETLAPEPLG PGQVRIAIRA TGLNFRDVLI 3000
ALGMYPDPAL MGTEGAGVVT ATGPGVTHLA PGDRVMGLLS GAYAPVVVAD 3050
ARTVARMPEG WTFAQGASVP VVFLTAVYAL RDLADVKPGE RLLVHSAAGG 3100
VGMAAVQLAR HWGVEVHGTA SHGKWDALRA LGLDDAHIAS SRTLDFESAF 3150
RAASGGAGMD VVLNSLAREF VDASLRLLGP GGRFVEMGKT DVRDAERVAA 3200
DHPGVGYRAF DLGEAGPERI GEMLAEVIAL FEDGVLRHLP VTTWDVRRAR 3250
DAFRHVSQAR HTGKVVLTMP SGLDPEGTVL LTGGTGALGG IVARHVVGEW 3300
GVRRLLLVSR RGTDAPGAGE LVHELEALGA DVSVAACDVA DREALTAVLD 3350
SIPAEHPLTA VVHTAGVLSD GTLPSMTAED VEHVLRPKVD AAFLLDELTS 3400
TPGYDLAAFV MFSSAAAVFG GAGQGAYAAA NATLDALAWR RRTAGLPALS 3450
LGWGLWAETS GMTGGLSDTD RSRLARSGAT PMDSELTLSL LDAAMRRDDP 3500
ALVPIALDVA ALRAQQRDGM LAPLLSGLTR GSRVGGAPVN QRRAAAGGAG 3550
EADTDLGGRL AAMTPDDRVA HLRDLVRTHV ATVLGHGTPS RVDLERAFRD 3600
TGFDSLTAVE LRNRLNAATG LRLPATLVFD HPTPGELAGH LLDELATAAG 3650
GSWAEGTGSG DTASATDRQT TAALAELDRL EGVLASLAPA AGGRPELAAR 3700
LRALAAALGD DGDDATDLDE ASDDDLFSFI DKELGDSDF 3739
Length:3,739
Mass (Da):387,178
Last modified:May 1, 1999 - v1
Checksum:i3D3910824DA5B080
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69330.1.
PIRiT17410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69330.1 .
PIRi T17410.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QP9 X-ray 1.88 A/B/C/D 920-1423 [» ]
ProteinModelPortali Q9ZGI4.
SMRi Q9ZGI4. Positions 6-913, 1435-1518, 1538-2409, 3555-3645.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-18412.

Family and domain databases

Gene3Di 1.10.1200.10. 2 hits.
3.40.366.10. 4 hits.
3.40.47.10. 4 hits.
3.40.50.720. 4 hits.
3.90.180.10. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 2 hits.
PF02801. Ketoacyl-synt_C. 2 hits.
PF08659. KR. 2 hits.
PF00550. PP-binding. 2 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 2 hits.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 2 hits.
SM00825. PKS_KS. 2 hits.
SM00823. PKS_PP. 2 hits.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 2 hits.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 4 hits.
SSF53901. SSF53901. 4 hits.
SSF55048. SSF55048. 2 hits.
PROSITEi PS50075. ACP_DOMAIN. 2 hits.
PS00606. B_KETOACYL_SYNTHASE. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 2 hits.
PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
    Xue Y., Zhao L., Liu H.W., Sherman D.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC15439Imported.
  2. "Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases."
    Zheng J., Keatinge-Clay A.T.
    J. Mol. Biol. 410:105-117(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 920-1423.

Entry informationi

Entry nameiQ9ZGI4_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGI4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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