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Q9ZGI3

- Q9ZGI3_STRVZ

UniProt

Q9ZGI3 - Q9ZGI3_STRVZ

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Protein
Submitted name: Type I polyketide synthase PikAIII
Gene
pikAIII
Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
  3. phosphopantetheine binding Source: InterPro
  4. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18413.

Names & Taxonomyi

Protein namesi
Submitted name:
Type I polyketide synthase PikAIIIImported
Gene namesi
Name:pikAIIIImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F5HX-ray1.75A/B1534-1562[»]
ProteinModelPortaliQ9ZGI3.
SMRiQ9ZGI3. Positions 5-905.

Miscellaneous databases

EvolutionaryTraceiQ9ZGI3.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00106. adh_short. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZGI3-1 [UniParc]FASTAAdd to Basket

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MANNEDKLRD YLKRVTAELQ QNTRRLREIE GRTHEPVAIV GMACRLPGGV     50
ASPEDLWQLV AGDGDAISEF PQDRGWDVEG LYDPDPDASG RTYCRSGGFL 100
HDAGEFDADF FGISPREALA MDPQQRLSLT TAWEAIESAG IDPTALKGSG 150
LGVFVGGWHT GYTSGQTTAV QSPELEGHLV SGAALGFLSG RIAYVLGTDG 200
PALTVDTACS SSLVALHLAV QALRKGECDM ALAGGVTVMP NADLFVQFSR 250
QRGLAADGRS KAFATSADGF GPAEGAGVLL VERLSDARRN GHRILAVVRG 300
SAVNQDGASN GLTAPHGPSQ QRVIRRALAD ARLAPGDVDV VEAHGTGTRL 350
GDPIEAQALI ATYGQEKSSE QPLRLGALKS NIGHTQAAAG VAGVIKMVQA 400
MRHGLLPKTL HVDEPSDQID WSAGTVELLT EAVDWPEKQD GGLRRAAVSS 450
FGISGTNAHV VLEEAPAVED SPAVEPPAGG GVVPWPVSAK TPAALDAQIG 500
QLAAYADGRT DVDPAVAARA LVDSRTAMEH RAVAVGDSRE ALRDALRMPE 550
GLVRGTSSDV GRVAFVFPGQ GTQWAGMGAE LLDSSPEFAA SMAECETALS 600
RYVDWSLEAV VRQEPGAPTL DRVDVVQPVT FAVMVSLAKV WQHHGITPQA 650
VVGHSQGEIA AAYVAGALTL DDAARVVTLR SKSIAAHLAG KGGMISLALD 700
EAAVLKRLSD FDGLSVAAVN GPTATVVSGD PTQIEELART CEADGVRARI 750
IPVDYASHSR QVEIIEKELA EVLAGLAPQA PHVPFFSTLE GTWITEPVLD 800
GTYWYRNLRH RVGFAPAVET LAVDGFTHFI EVSAHPVLTM TLPETVTGLG 850
TLRREQGGQE RLVTSLAEAW ANGLTIDWAP ILPTATGHHP ELPTYAFQTE 900
RFWLQSSAPT SAADDWRYRV EWKPLTASGQ ADLSGRWIVA VGSEPEAELL 950
GALKAAGAEV DVLEAGADDD REALAARLTA LTTGDGFTGV VSLLDDLVPQ 1000
VAWVQALGDA GIKAPLWSVT QGAVSVGRLD TPADPDRAML WGLGRVVALE 1050
HPERWAGLVD LPAQPDAAAL AHLVTALSGA TGEDQIAIRT TGLHARRLAR 1100
APLHGRRPTR DWQPHGTVLI TGGTGALGSH AARWMAHHGA EHLLLVSRSG 1150
EQAPGATQLT AELTASGARV TIAACDVADP HAMRTLLDAI PAETPLTAVV 1200
HTAGAPGGDP LDVTGPEDIA RILGAKTSGA EVLDDLLRGT PLDAFVLYSS 1250
NAGVWGSGSQ GVYAAANAHL DALAARRRAR GETATSVAWG LWAGDGMGRG 1300
ADDAYWQRRG IRPMSPDRAL DELAKALSHD ETFVAVADVD WERFAPAFTV 1350
SRPSLLLDGV PEARQALAAP VGAPAPGDAA VAPTGQSSAL AAITALPEPE 1400
RRPALLTLVR THAAAVLGHS SPDRVAPGRA FTELGFDSLT AVQLRNQLST 1450
VVGNRLPATT VFDHPTPAAL AAHLHEAYLA PAEPAPTDWE GRVRRALAEL 1500
PLDRLRDAGV LDTVLRLTGI EPEPGSGGSD GGAADPGAEP EASIDDLDAE 1550
ALIRMALGPR NT 1562
Length:1,562
Mass (Da):163,594
Last modified:May 1, 1999 - v1
Checksum:iDB4BA0DAAA15B63F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69331.1.
PIRiT17411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079138 Genomic DNA. Translation: AAC69331.1 .
PIRi T17411.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F5H X-ray 1.75 A/B 1534-1562 [» ]
ProteinModelPortali Q9ZGI3.
SMRi Q9ZGI3. Positions 5-905.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-18413.

Miscellaneous databases

EvolutionaryTracei Q9ZGI3.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF00106. adh_short. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
SMARTi SM00827. PKS_AT. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view ]
SUPFAMi SSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
    Xue Y., Zhao L., Liu H.W., Sherman D.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC15439Imported.
  2. "Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains."
    Buchholz T.J., Geders T.W., Bartley F.E., Reynolds K.A., Smith J.L., Sherman D.H.
    ACS Chem. Biol. 4:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1534-1562.

Entry informationi

Entry nameiQ9ZGI3_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGI3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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