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Q9ZGI3

- Q9ZGI3_STRVZ

UniProt

Q9ZGI3 - Q9ZGI3_STRVZ

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Protein
Submitted name:

Type I polyketide synthase PikAIII

Gene

pikAIII

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. oxidoreductase activity Source: InterPro
  3. phosphopantetheine binding Source: InterPro
  4. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18413.

Names & Taxonomyi

Protein namesi
Submitted name:
Type I polyketide synthase PikAIIIImported
Gene namesi
Name:pikAIIIImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Interactioni

Protein-protein interaction databases

DIPiDIP-61040N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F5HX-ray1.75A/B1534-1562[»]
ProteinModelPortaliQ9ZGI3.
SMRiQ9ZGI3. Positions 5-905.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZGI3.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00106. adh_short. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZGI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANNEDKLRD YLKRVTAELQ QNTRRLREIE GRTHEPVAIV GMACRLPGGV
60 70 80 90 100
ASPEDLWQLV AGDGDAISEF PQDRGWDVEG LYDPDPDASG RTYCRSGGFL
110 120 130 140 150
HDAGEFDADF FGISPREALA MDPQQRLSLT TAWEAIESAG IDPTALKGSG
160 170 180 190 200
LGVFVGGWHT GYTSGQTTAV QSPELEGHLV SGAALGFLSG RIAYVLGTDG
210 220 230 240 250
PALTVDTACS SSLVALHLAV QALRKGECDM ALAGGVTVMP NADLFVQFSR
260 270 280 290 300
QRGLAADGRS KAFATSADGF GPAEGAGVLL VERLSDARRN GHRILAVVRG
310 320 330 340 350
SAVNQDGASN GLTAPHGPSQ QRVIRRALAD ARLAPGDVDV VEAHGTGTRL
360 370 380 390 400
GDPIEAQALI ATYGQEKSSE QPLRLGALKS NIGHTQAAAG VAGVIKMVQA
410 420 430 440 450
MRHGLLPKTL HVDEPSDQID WSAGTVELLT EAVDWPEKQD GGLRRAAVSS
460 470 480 490 500
FGISGTNAHV VLEEAPAVED SPAVEPPAGG GVVPWPVSAK TPAALDAQIG
510 520 530 540 550
QLAAYADGRT DVDPAVAARA LVDSRTAMEH RAVAVGDSRE ALRDALRMPE
560 570 580 590 600
GLVRGTSSDV GRVAFVFPGQ GTQWAGMGAE LLDSSPEFAA SMAECETALS
610 620 630 640 650
RYVDWSLEAV VRQEPGAPTL DRVDVVQPVT FAVMVSLAKV WQHHGITPQA
660 670 680 690 700
VVGHSQGEIA AAYVAGALTL DDAARVVTLR SKSIAAHLAG KGGMISLALD
710 720 730 740 750
EAAVLKRLSD FDGLSVAAVN GPTATVVSGD PTQIEELART CEADGVRARI
760 770 780 790 800
IPVDYASHSR QVEIIEKELA EVLAGLAPQA PHVPFFSTLE GTWITEPVLD
810 820 830 840 850
GTYWYRNLRH RVGFAPAVET LAVDGFTHFI EVSAHPVLTM TLPETVTGLG
860 870 880 890 900
TLRREQGGQE RLVTSLAEAW ANGLTIDWAP ILPTATGHHP ELPTYAFQTE
910 920 930 940 950
RFWLQSSAPT SAADDWRYRV EWKPLTASGQ ADLSGRWIVA VGSEPEAELL
960 970 980 990 1000
GALKAAGAEV DVLEAGADDD REALAARLTA LTTGDGFTGV VSLLDDLVPQ
1010 1020 1030 1040 1050
VAWVQALGDA GIKAPLWSVT QGAVSVGRLD TPADPDRAML WGLGRVVALE
1060 1070 1080 1090 1100
HPERWAGLVD LPAQPDAAAL AHLVTALSGA TGEDQIAIRT TGLHARRLAR
1110 1120 1130 1140 1150
APLHGRRPTR DWQPHGTVLI TGGTGALGSH AARWMAHHGA EHLLLVSRSG
1160 1170 1180 1190 1200
EQAPGATQLT AELTASGARV TIAACDVADP HAMRTLLDAI PAETPLTAVV
1210 1220 1230 1240 1250
HTAGAPGGDP LDVTGPEDIA RILGAKTSGA EVLDDLLRGT PLDAFVLYSS
1260 1270 1280 1290 1300
NAGVWGSGSQ GVYAAANAHL DALAARRRAR GETATSVAWG LWAGDGMGRG
1310 1320 1330 1340 1350
ADDAYWQRRG IRPMSPDRAL DELAKALSHD ETFVAVADVD WERFAPAFTV
1360 1370 1380 1390 1400
SRPSLLLDGV PEARQALAAP VGAPAPGDAA VAPTGQSSAL AAITALPEPE
1410 1420 1430 1440 1450
RRPALLTLVR THAAAVLGHS SPDRVAPGRA FTELGFDSLT AVQLRNQLST
1460 1470 1480 1490 1500
VVGNRLPATT VFDHPTPAAL AAHLHEAYLA PAEPAPTDWE GRVRRALAEL
1510 1520 1530 1540 1550
PLDRLRDAGV LDTVLRLTGI EPEPGSGGSD GGAADPGAEP EASIDDLDAE
1560
ALIRMALGPR NT
Length:1,562
Mass (Da):163,594
Last modified:May 1, 1999 - v1
Checksum:iDB4BA0DAAA15B63F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079138 Genomic DNA. Translation: AAC69331.1.
PIRiT17411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079138 Genomic DNA. Translation: AAC69331.1 .
PIRi T17411.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F5H X-ray 1.75 A/B 1534-1562 [» ]
ProteinModelPortali Q9ZGI3.
SMRi Q9ZGI3. Positions 5-905.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-61040N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-18413.

Miscellaneous databases

EvolutionaryTracei Q9ZGI3.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF00106. adh_short. 1 hit.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
SMARTi SM00827. PKS_AT. 1 hit.
SM00822. PKS_KR. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view ]
SUPFAMi SSF101173. SSF101173. 1 hit.
SSF47336. SSF47336. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 3 hits.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
    Xue Y., Zhao L., Liu H.W., Sherman D.H.
    Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC15439Imported.
  2. "Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains."
    Buchholz T.J., Geders T.W., Bartley F.E., Reynolds K.A., Smith J.L., Sherman D.H.
    ACS Chem. Biol. 4:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1534-1562.

Entry informationi

Entry nameiQ9ZGI3_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGI3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3