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Q9ZGI3

- Q9ZGI3_STRVZ

UniProt

Q9ZGI3 - Q9ZGI3_STRVZ

Protein
Submitted name:

Type I polyketide synthase PikAIII

Gene

pikAIII

Organism
Streptomyces venezuelae
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cofactor binding Source: InterPro
    2. oxidoreductase activity Source: InterPro
    3. phosphopantetheine binding Source: InterPro
    4. transferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18413.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Type I polyketide synthase PikAIIIImported
    Gene namesi
    Name:pikAIIIImported
    OrganismiStreptomyces venezuelaeImported
    Taxonomic identifieri54571 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3F5HX-ray1.75A/B1534-1562[»]
    ProteinModelPortaliQ9ZGI3.
    SMRiQ9ZGI3. Positions 5-905.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZGI3.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProiIPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    PF00106. adh_short. 1 hit.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    SMARTiSM00827. PKS_AT. 1 hit.
    SM00822. PKS_KR. 1 hit.
    SM00825. PKS_KS. 1 hit.
    SM00823. PKS_PP. 1 hit.
    [Graphical view]
    SUPFAMiSSF101173. SSF101173. 1 hit.
    SSF47336. SSF47336. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53901. SSF53901. 3 hits.
    SSF55048. SSF55048. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZGI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANNEDKLRD YLKRVTAELQ QNTRRLREIE GRTHEPVAIV GMACRLPGGV     50
    ASPEDLWQLV AGDGDAISEF PQDRGWDVEG LYDPDPDASG RTYCRSGGFL 100
    HDAGEFDADF FGISPREALA MDPQQRLSLT TAWEAIESAG IDPTALKGSG 150
    LGVFVGGWHT GYTSGQTTAV QSPELEGHLV SGAALGFLSG RIAYVLGTDG 200
    PALTVDTACS SSLVALHLAV QALRKGECDM ALAGGVTVMP NADLFVQFSR 250
    QRGLAADGRS KAFATSADGF GPAEGAGVLL VERLSDARRN GHRILAVVRG 300
    SAVNQDGASN GLTAPHGPSQ QRVIRRALAD ARLAPGDVDV VEAHGTGTRL 350
    GDPIEAQALI ATYGQEKSSE QPLRLGALKS NIGHTQAAAG VAGVIKMVQA 400
    MRHGLLPKTL HVDEPSDQID WSAGTVELLT EAVDWPEKQD GGLRRAAVSS 450
    FGISGTNAHV VLEEAPAVED SPAVEPPAGG GVVPWPVSAK TPAALDAQIG 500
    QLAAYADGRT DVDPAVAARA LVDSRTAMEH RAVAVGDSRE ALRDALRMPE 550
    GLVRGTSSDV GRVAFVFPGQ GTQWAGMGAE LLDSSPEFAA SMAECETALS 600
    RYVDWSLEAV VRQEPGAPTL DRVDVVQPVT FAVMVSLAKV WQHHGITPQA 650
    VVGHSQGEIA AAYVAGALTL DDAARVVTLR SKSIAAHLAG KGGMISLALD 700
    EAAVLKRLSD FDGLSVAAVN GPTATVVSGD PTQIEELART CEADGVRARI 750
    IPVDYASHSR QVEIIEKELA EVLAGLAPQA PHVPFFSTLE GTWITEPVLD 800
    GTYWYRNLRH RVGFAPAVET LAVDGFTHFI EVSAHPVLTM TLPETVTGLG 850
    TLRREQGGQE RLVTSLAEAW ANGLTIDWAP ILPTATGHHP ELPTYAFQTE 900
    RFWLQSSAPT SAADDWRYRV EWKPLTASGQ ADLSGRWIVA VGSEPEAELL 950
    GALKAAGAEV DVLEAGADDD REALAARLTA LTTGDGFTGV VSLLDDLVPQ 1000
    VAWVQALGDA GIKAPLWSVT QGAVSVGRLD TPADPDRAML WGLGRVVALE 1050
    HPERWAGLVD LPAQPDAAAL AHLVTALSGA TGEDQIAIRT TGLHARRLAR 1100
    APLHGRRPTR DWQPHGTVLI TGGTGALGSH AARWMAHHGA EHLLLVSRSG 1150
    EQAPGATQLT AELTASGARV TIAACDVADP HAMRTLLDAI PAETPLTAVV 1200
    HTAGAPGGDP LDVTGPEDIA RILGAKTSGA EVLDDLLRGT PLDAFVLYSS 1250
    NAGVWGSGSQ GVYAAANAHL DALAARRRAR GETATSVAWG LWAGDGMGRG 1300
    ADDAYWQRRG IRPMSPDRAL DELAKALSHD ETFVAVADVD WERFAPAFTV 1350
    SRPSLLLDGV PEARQALAAP VGAPAPGDAA VAPTGQSSAL AAITALPEPE 1400
    RRPALLTLVR THAAAVLGHS SPDRVAPGRA FTELGFDSLT AVQLRNQLST 1450
    VVGNRLPATT VFDHPTPAAL AAHLHEAYLA PAEPAPTDWE GRVRRALAEL 1500
    PLDRLRDAGV LDTVLRLTGI EPEPGSGGSD GGAADPGAEP EASIDDLDAE 1550
    ALIRMALGPR NT 1562
    Length:1,562
    Mass (Da):163,594
    Last modified:May 1, 1999 - v1
    Checksum:iDB4BA0DAAA15B63F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69331.1.
    PIRiT17411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079138 Genomic DNA. Translation: AAC69331.1 .
    PIRi T17411.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3F5H X-ray 1.75 A/B 1534-1562 [» ]
    ProteinModelPortali Q9ZGI3.
    SMRi Q9ZGI3. Positions 5-905.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-18413.

    Miscellaneous databases

    EvolutionaryTracei Q9ZGI3.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.720. 1 hit.
    InterProi IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    PF00106. adh_short. 1 hit.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00827. PKS_AT. 1 hit.
    SM00822. PKS_KR. 1 hit.
    SM00825. PKS_KS. 1 hit.
    SM00823. PKS_PP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101173. SSF101173. 1 hit.
    SSF47336. SSF47336. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53901. SSF53901. 3 hits.
    SSF55048. SSF55048. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity."
      Xue Y., Zhao L., Liu H.W., Sherman D.H.
      Proc. Natl. Acad. Sci. U.S.A. 95:12111-12116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15439Imported.
    2. "Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains."
      Buchholz T.J., Geders T.W., Bartley F.E., Reynolds K.A., Smith J.L., Sherman D.H.
      ACS Chem. Biol. 4:41-52(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1534-1562.

    Entry informationi

    Entry nameiQ9ZGI3_STRVZ
    AccessioniPrimary (citable) accession number: Q9ZGI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3