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Protein

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

Gene

desV

Organism
Streptomyces venezuelae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics. Catalyzes the reversible transfer of the amino group from L-glutamate to the C-3 position of dTDP-3-keto-4,6-deoxyglucose to yield dTDP-3-amino-3,4,6-trideoxyglucose.1 Publication

Catalytic activityi

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate.1 Publication

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: Antibiotic biosynthesis

This protein is involved in Antibiotic biosynthesis.Curated
View all proteins of this organism that are known to be involved in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Pyridoxal phosphate; via amide nitrogen1 Publication
Binding sitei167 – 1671Pyridoxal phosphate1 Publication
Binding sitei221 – 2211Pyridoxal phosphate1 Publication
Binding sitei227 – 2271Pyridoxal phosphate1 Publication
Binding sitei318 – 3181Pyridoxal phosphate1 Publication

GO - Molecular functioni

  • pyridoxal phosphate binding Source: UniProtKB
  • transaminase activity Source: UniProtKB

GO - Biological processi

  • macrolide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16953.
BRENDAi2.6.1.106. 6106.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase1 Publication (EC:2.6.1.1061 Publication)
Gene namesi
Name:desV1 Publication
OrganismiStreptomyces venezuelae
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminasePRO_0000430832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931N6-(pyridoxal phosphate)lysine1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
379
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 217Combined sources
Helixi23 – 3614Combined sources
Beta strandi40 – 423Combined sources
Helixi43 – 5513Combined sources
Beta strandi58 – 658Combined sources
Helixi67 – 7711Combined sources
Beta strandi85 – 928Combined sources
Helixi95 – 1028Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi114 – 1196Combined sources
Helixi121 – 1277Combined sources
Beta strandi132 – 1354Combined sources
Helixi140 – 1423Combined sources
Helixi147 – 15711Combined sources
Beta strandi160 – 1645Combined sources
Beta strandi184 – 1885Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi202 – 2076Combined sources
Helixi209 – 21911Combined sources
Helixi240 – 25112Combined sources
Helixi253 – 27018Combined sources
Turni271 – 2733Combined sources
Beta strandi291 – 2966Combined sources
Helixi300 – 30910Combined sources
Helixi322 – 3243Combined sources
Helixi326 – 3294Combined sources
Helixi339 – 3479Combined sources
Beta strandi348 – 3514Combined sources
Helixi359 – 37416Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OGAX-ray2.05A/B/C/D1-379[»]
2OGEX-ray2.05A/B/C/D1-379[»]
ProteinModelPortaliQ9ZGH4.
SMRiQ9ZGH4. Positions 7-377.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZGH4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1936Pyridoxal phosphate binding1 Publication
Regioni235 – 2373Pyridoxal phosphate binding1 Publication

Sequence similaritiesi

Belongs to the degT/dnrJ/eryC1 family.Curated

Phylogenomic databases

KOiK13310.

Family and domain databases

CDDicd00616. AHBA_syn. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view]
PIRSFiPIRSF000390. PLP_StrS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZGH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRAETPRV PFLDLKAAYE ELRAETDAAI ARVLDSGRYL LGPELEGFEA
60 70 80 90 100
EFAAYCETDH AVGVNSGMDA LQLALRGLGI GPGDEVIVPS HTYIASWLAV
110 120 130 140 150
SATGATPVPV EPHEDHPTLD PLLVEKAITP RTRALLPVHL YGHPADMDAL
160 170 180 190 200
RELADRHGLH IVEDAAQAHG ARYRGRRIGA GSSVAAFSFY PGKNLGCFGD
210 220 230 240 250
GGAVVTGDPE LAERLRMLRN YGSRQKYSHE TKGTNSRLDE MQAAVLRIRL
260 270 280 290 300
AHLDSWNGRR SALAAEYLSG LAGLPGIGLP VTAPDTDPVW HLFTVRTERR
310 320 330 340 350
DELRSHLDAR GIDTLTHYPV PVHLSPAYAG EAPPEGSLPR AESFARQVLS
360 370
LPIGPHLERP QALRVIDAVR EWAERVDQA
Length:379
Mass (Da):41,184
Last modified:May 1, 1999 - v1
Checksum:i1A4FD0F4E76DCCDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079762 Genomic DNA. Translation: AAC68680.1.
RefSeqiWP_055641633.1. NZ_LN881739.1.

Genome annotation databases

KEGGiag:AAC68680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079762 Genomic DNA. Translation: AAC68680.1.
RefSeqiWP_055641633.1. NZ_LN881739.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OGAX-ray2.05A/B/C/D1-379[»]
2OGEX-ray2.05A/B/C/D1-379[»]
ProteinModelPortaliQ9ZGH4.
SMRiQ9ZGH4. Positions 7-377.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAC68680.

Phylogenomic databases

KOiK13310.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16953.
BRENDAi2.6.1.106. 6106.

Miscellaneous databases

EvolutionaryTraceiQ9ZGH4.

Family and domain databases

CDDicd00616. AHBA_syn. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view]
PIRSFiPIRSF000390. PLP_StrS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDESV_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.