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Protein

dTDP-glucose 4,6-dehydratase

Gene

desIV

Organism
Streptomyces venezuelae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.UniRule annotation

Cofactori

NAD+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83NAD; via carbonyl oxygenCombined sources1
Binding sitei87NADCombined sources1
Binding sitei151NADCombined sources1
Binding sitei155NADCombined sources1
Binding sitei181NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12NADCombined sources3
Nucleotide bindingi37 – 40NADCombined sources4
Nucleotide bindingi63 – 64NADCombined sources2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
LigandNADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16952.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydrataseUniRule annotation (EC:4.2.1.46UniRule annotation)
Gene namesi
Name:desIVImported
OrganismiStreptomyces venezuelaeImported
Taxonomic identifieri54571 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Pathology & Biotechi

Chemistry databases

DrugBankiDB03751. 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R66X-ray1.44A1-337[»]
1R6DX-ray1.35A1-337[»]
ProteinModelPortaliQ9ZGH3.
SMRiQ9ZGH3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZGH3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 306NAD(P)-bd_domInterPro annotationAdd BLAST303

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR005888. dTDP_Gluc_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
PfamiView protein in Pfam
PF16363. GDP_Man_Dehyd. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZGH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVTGGAG FIGSHFVRQL LAGAYPDVPA DEVIVLDSLT YAGNRANLAP
60 70 80 90 100
VDADPRLRFV HGDIRDAGLL ARELRGVDAI VHFAAESHVD RSIAGASVFT
110 120 130 140 150
ETNVQGTQTL LQCAVDAGVG RVVHVSTDEV YGSIDSGSWT ESSPLEPNSP
160 170 180 190 200
YAASKAGSDL VARAYHRTYG LDVRITRCCN NYGPYQHPEK LIPLFVTNLL
210 220 230 240 250
DGGTLPLYGD GANVREWVHT DDHCRGIALV LAGGRAGEIY HIGGGLELTN
260 270 280 290 300
RELTGILLDS LGADWSSVRK VADRKGHDLR YSLDGGEIER ELGYRPQVSF
310 320 330
ADGLARTVRW YRENRGWWEP LKATAPQLPA TAVEVSA
Length:337
Mass (Da):36,457
Last modified:May 1, 1999 - v1
Checksum:i753443EFCE3A128C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079762 Genomic DNA. Translation: AAC68681.1.

Similar proteinsi

Entry informationi

Entry nameiQ9ZGH3_STRVZ
AccessioniPrimary (citable) accession number: Q9ZGH3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources