Unreviewed, UniProtKB/TrEMBL Q9ZFY9 (Q9ZFY9_COMTE)

Names and origin

Protein names	Submitted name:     3alpha-hydroxysteroid dehydrogenase/carbonyl reductase EMBL AAC79849.1
Organism	Comamonas testosteroni (Pseudomonas testosteroni) EMBL AAC79849.1
Taxonomic identifier	285 [NCBI]
Taxonomic lineage	Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Comamonas

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

Ontologies

Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9ZFY9-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 65B6F19444F20EFE	FASTA	257	26,392
	10 20 30 40 50 60 MSIIVISGCA TGIGAATRKV LEAAGHQIVG IDIRDAEVIA DLSTAEGRKQ AIADVLAKCS 70 80 90 100 110 120 KGMDGLVLCA GLGPQTKVLG NVVSVNYFGA TELMDAFLPA LKKGHQPAAV VISSVASAHL 130 140 150 160 170 180 AFDKNPLALA LEAGEEAKAR AIVEHAGEQG GNLAYAGSKN ALTVAVRKRA AAWGEAGVRL 190 200 210 220 230 240 NTIAPGATET PLLQAGLQDP RYGESIAKFV PPMGRRAEPS EMASVIAFLM SPAASYVHGA 250 QIVIDGGIDA VMRPTQF

References

[1]	"Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily." Mobus E., Maser E. J. Biol. Chem. 273:30888-30896(1998) [PubMed: 9812981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC11996 EMBL AAC79849.1.
[2]	"Regulation of the steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase gene in Comamonas testosteroni." Xiong G., Maser E. J. Biol. Chem. 276:9961-9970(2001) [PubMed: 11139589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC11996 EMBL AAC79849.1.
[3]	Xiong G., Moebus E., Maser E. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC11996 EMBL AAC79849.1.
[4]	"Functional expression, purification, and characterization of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni." Maser E., Mobus E., Xiong G. Biochem. Biophys. Res. Commun. 272:622-628(2000) [PubMed: 10833462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family." Grimm C., Maser E., Mobus E., Klebe G., Reuter K., Ficner R. J. Biol. Chem. 275:41333-41339(2000) [PubMed: 11007791] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF092031 Genomic DNA. Translation: AAC79849.1.

PIR

JC7291.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FJH	X-ray	1.68	A/B	1-257	[»]
1FK8	X-ray	1.95	A/B	1-257	[»]

ModBase

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Family and domain databases

InterPro

IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

PANTHER

PTHR19410. ADH_short_C2. 1 hit.

PRINTS

PR00081. GDHRDH.

ProtoNet

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Entry information

Entry name

Q9ZFY9_COMTE

Accession

Primary (citable) accession number: Q9ZFY9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)