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Reviewed, UniProtKB/Swiss-Prot Q9ZFV8 (MAO2_SALTY)

Last modified June 16, 2009. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NADP-dependent malic enzyme
      Short name=NADP-ME
    EC=1.1.1.40
Gene names
Name: maeB
Ordered Locus Names: STM2472
OrganismSalmonella typhimurium [Complete proteome] [HAMAP]
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

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Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-malate + NADP+ = pyruvate + CO2 + NADPH.

Cofactor

Divalent metal cations. Prefers magnesium or manganese By similarity.

Sequence similarities

In the N-terminal section; belongs to the malic enzymes family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759NADP-dependent malic enzyme
PRO_0000160244

Regions

Nucleotide binding76 – 838NADP By similarity
Region1 – 428428Malic enzyme
Region429 – 759331Phosphate acetyltransferase

Sites

Active site941Proton acceptor By similarity
Metal binding1361Divalent metal cation By similarity
Metal binding1371Divalent metal cation By similarity
Binding site1621NAD By similarity
Binding site2881NAD By similarity

Experimental info

Sequence conflict6101A → G in AAC78109. Ref.2
Sequence conflict6131A → P in AAC78109. Ref.2
Sequence conflict6211R → H in AAC78109. Ref.2
Sequence conflict6261E → G in AAC78109. Ref.2
Sequence conflict6351S → C in AAC78109. Ref.2
Sequence conflict6431L → P in AAC78109. Ref.2
Sequence conflict6791R → C in AAC78109. Ref.2
Sequence conflict7541A → G in AAC78109. Ref.2
Sequence conflict7571T → Q in AAC78109. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9ZFV8-1 [UniParc].

Last modified December 13, 2001. Version 2.
Checksum: D5120B020158EF18

FASTA75982,322
        10         20         30         40         50         60 
MDEQLKQSAL DFHEFPVPGK IQVSPTKPLA TQRDLALAYS PGVAAPCLEI EKDPLAAYKY 

        70         80         90        100        110        120 
TARGNLVAVI SNGTAVLGLG NIGALAGKPV MEGKGVLFKK FAGIDVFDIE VDELDPDKFI 

       130        140        150        160        170        180 
NVVAALEPTF GGINLEDIKA PECFYIEQKL RERMNIPVFH DDQHGTAIIS TAAILNGLRV 

       190        200        210        220        230        240 
VEKNISDVRM VVSGAGAAAI ACMNLLVALG MQKHNIVVCD SKGVIYKGRE PNMAETKAAY 

       250        260        270        280        290        300 
AVDDSGKRTL DEVIDGADIF LGCSGPKVLT QEMVKKMARA PMILALANPE PEILPPLAKE 

       310        320        330        340        350        360 
VRPDAIICTG RSDYPNQVNN VLCFPFIFRG ALDVGATAIN EEMKLAAVRA IAELAHAEQS 

       370        380        390        400        410        420 
EVVASAYGDQ DLSFGPEYII PKPFDPRLIV KIAPAVAKAA MDSGVATRPI ADFDAYIDKL 

       430        440        450        460        470        480 
TEFVYKTNLF MKPIFSQARK DPKRVVLPEG EEARVLHATQ ELITLGLAKP ILIGRPSVIE 

       490        500        510        520        530        540 
MRIQKLGLQI KAGVDFEIVN NESDPRFKEY WSEYYQIMKR RGITQEQAQR AMIGNHTAIG 

       550        560        570        580        590        600 
AIMVQRGEAD AMICGTIGDY HEHFSVVKAV FGYRDGVHTA GAMNALLLPS GNTFIADTYV 

       610        620        630        640        650        660 
NEDPTPEQLA EIAVMAAETV RRFGIEPKVA LLSHSNFGSS NSLSASKMRE TLERVRERAP 

       670        680        690        700        710        720 
DLMIDGEMHG DAALVESIRN DRMPDSPLKG AANILVMPNM EAARISYNLL RVSSSEGVTV 

       730        740        750 
GPVLMGVSKP VHVLTPIASV RRIVNMVALA VVEAQTTPL

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References

« Hide 'large scale' references
[1]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[2]"The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins."
Kofoid E.C., Rappleye C.A., Stojiljkovic I., Roth J.R.
J. Bacteriol. 181:5317-5329(1999) [PubMed: 10464203] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 610-759.
Strain: LT2.

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Cross-references

Sequence databases

AE008811 Genomic DNA. Translation: AAL21366.1.
AF093749 Genomic DNA. Translation: AAC78109.1.
RefSeqNP_461407.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1253994.
GenomeReviewsGene locus STM2472 in contig AE006468_GR.
KEGGstm:STM2472.
NMPDRfig|99287.1.peg.2388.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9ZFV8.
OMAQ9ZFV8. EIRPELA.

Enzyme and pathway databases

BioCycSTYP99287:STM2472-MON.
BRENDA1.1.1.40. 2.

Family and domain databases

InterProIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N.
IPR012302. Malic_NAD_bd.
IPR012188. ME_PTA.
IPR016040. NAD(P)-bd_dom.
IPR002505. PTA_PTB.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF036684. ME_PTA. 1 hit.
PROSITEPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMAO2_SALTY
AccessionPrimary (citable) accession number: Q9ZFV8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 13, 2001
Last modified: June 16, 2009
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents