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Protein
Submitted name:

Exotoxin 3

Gene

set3

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei207 – 2071GalactoseCombined sources
Binding sitei213 – 2131GalactoseCombined sources
Binding sitei213 – 2131N-acetyl-D-glucosamineCombined sources

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Exotoxin 3Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:set3Imported
ORF Names:AL077_09640Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 234204Sequence analysisPRO_5007217139Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4VX-ray1.90A/B31-234[»]
2R61X-ray2.75A31-234[»]
2Z8LX-ray1.65A31-234[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12883SSL_OBInterPro annotationAdd
BLAST
Domaini157 – 21559Stap_Strp_tox_CInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2137Fucose bindingCombined sources

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR015282. SSL_OB.
IPR006126. Staph/Strept_toxin_CS.
IPR008375. Staph_exotoxin.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
[Graphical view]
PfamiPF09199. SSL_OB. 1 hit.
PF02876. Stap_Strp_tox_C. 1 hit.
[Graphical view]
PRINTSiPR01898. SAGSUPRFAMLY.
PR01800. STAPHEXOTOXN.
PR01501. TOXICSSTOXIN.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZFS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTAIAKAS LALSILATGV ITSTAQTVNA SEHESKYENV TKDIFDLRDY
60 70 80 90 100
YSRASKELKN VTGYRYSKGG KHYLIFDKNR KFTRIQIFGK DIERIKKRKN
110 120 130 140 150
PGLDIFVVKE AENRNGTVYS YGGVTKKNQG AYYDYLSAPR FVIKKEVGAG
160 170 180 190 200
VSVHVKRYYI YKEEISLKEL DFKLRQYLIQ DFDLYKKFPK ASKIKVTMKD
210 220 230
GGYYTFELNK KLQTNRMSDV IDGRNIEKIE ANIR
Length:234
Mass (Da):27,103
Last modified:May 1, 1999 - v1
Checksum:iE488C0EC35E1AE67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094826 Genomic DNA. Translation: AAC69191.1.
LIGV01000014 Genomic DNA. Translation: KQB70059.1.
RefSeqiWP_000784258.1. NZ_LN626917.1.

Genome annotation databases

EnsemblBacteriaiKLM35069; KLM35069; RK78_04910.
KLM85195; KLM85195; RK90_13965.
KLM87033; KLM87033; RK88_09210.
KQB70059; KQB70059; AL077_09640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094826 Genomic DNA. Translation: AAC69191.1.
LIGV01000014 Genomic DNA. Translation: KQB70059.1.
RefSeqiWP_000784258.1. NZ_LN626917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4VX-ray1.90A/B31-234[»]
2R61X-ray2.75A31-234[»]
2Z8LX-ray1.65A31-234[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKLM35069; KLM35069; RK78_04910.
KLM85195; KLM85195; RK90_13965.
KLM87033; KLM87033; RK88_09210.
KQB70059; KQB70059; AL077_09640.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR015282. SSL_OB.
IPR006126. Staph/Strept_toxin_CS.
IPR008375. Staph_exotoxin.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
[Graphical view]
PfamiPF09199. SSL_OB. 1 hit.
PF02876. Stap_Strp_tox_C. 1 hit.
[Graphical view]
PRINTSiPR01898. SAGSUPRFAMLY.
PR01800. STAPHEXOTOXN.
PR01501. TOXICSSTOXIN.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1."
    Williams R.J., Ward J.M., Henderson B., Poole S., O'Hara B.P., Wilson M., Nair S.P.
    Infect. Immun. 68:4407-4415(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome."
    Arcus V.L., Langley R., Proft T., Fraser J.D., Baker E.N.
    J. Biol. Chem. 277:32274-32281(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 31-234.
  3. "Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins."
    Baker H.M., Basu I., Chung M.C., Caradoc-Davies T., Fraser J.D., Baker E.N.
    J. Mol. Biol. 374:1298-1308(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 31-234 IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
  4. "Analysis of methicillin-resistant Staphylococcus aureus ST5 and ST30 strains colonizing healthy children in public daycare centers in Niteroi, Brazil."
    Stephens C.M., Cho P.J., Braga E.D., Cardoso C.A., Riley L.W., Alves F.A.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CC175Imported.

Entry informationi

Entry nameiQ9ZFS6_STAAU
AccessioniPrimary (citable) accession number: Q9ZFS6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.